Long Chen
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View article: VExUS Ultrasound-Based Noninvasive Risk Stratification Model for Esophageal Variceal Bleeding in Cirrhosis
VExUS Ultrasound-Based Noninvasive Risk Stratification Model for Esophageal Variceal Bleeding in Cirrhosis Open
Background Esophageal variceal bleeding (EVB) is a life-threatening complication of cirrhosis, necessitating accurate risk stratification. Current non-invasive methods lack sensitivity to dynamic hemodynamic changes. This study aimed to de…
View article: Transcriptomic analysis reveals cell wall polysaccharide metabolism associated with post-harvest softening in shiitake mushrooms (Lentinula edodes)
Transcriptomic analysis reveals cell wall polysaccharide metabolism associated with post-harvest softening in shiitake mushrooms (Lentinula edodes) Open
View article: Comprehensive pan-cancer evaluation of NUP85 prognosis, immune infiltration response, and validation in prostate cancer
Comprehensive pan-cancer evaluation of NUP85 prognosis, immune infiltration response, and validation in prostate cancer Open
View article: Dynamic Self‐Optimizing Interfaces via Cu Corrosion and Anion‐Vacancy Synergy in SnSSe @ Recycled Graphite Anodes for High‐Performance Sodium‐Ion Batteries
Dynamic Self‐Optimizing Interfaces via Cu Corrosion and Anion‐Vacancy Synergy in SnSSe @ Recycled Graphite Anodes for High‐Performance Sodium‐Ion Batteries Open
Tin sulfide (SnS 2 ) anodes for sodium‐ion batteries (SIBs) exhibit high theoretical capacity (1136 mAh g −1 ) but face sluggish kinetics and structural instability due to volume expansion and poor conductivity. This work proposes a dual‐d…
View article: Efficacy and safety of linezolid versus vancomycin for the treatment of central nervous system infections: a meta-analysis
Efficacy and safety of linezolid versus vancomycin for the treatment of central nervous system infections: a meta-analysis Open
View article: Association of Diaphragm Involvement Assessed by Ultrasound With Disease Severity in Facioscapulohumeral Muscular Dystrophy
Association of Diaphragm Involvement Assessed by Ultrasound With Disease Severity in Facioscapulohumeral Muscular Dystrophy Open
Background Respiratory involvement is a comorbidity that should not be overlooked in clinical practice in facioscapulohumeral muscular dystrophy type 1 (FSHD1), with a reported association for severe disease outcomes such as wheelchair dep…
View article: Enhanced vitamin B6 production in engineered Escherichia coli via restricted mix-carbon feeding and pressure-controlled fermentation
Enhanced vitamin B6 production in engineered Escherichia coli via restricted mix-carbon feeding and pressure-controlled fermentation Open
View article: Biomechanical effects of six internal fixation methods for distal femoral AO/OTA 33C1 fractures: finite element analysis
Biomechanical effects of six internal fixation methods for distal femoral AO/OTA 33C1 fractures: finite element analysis Open
The combination of a 5-hole lateral plate and a medial T-shaped plate demonstrated significant biomechanical advantage compared to the other five groups. Although the 5-hole lateral plate model is slightly inferior compared to the 5-hole l…
View article: Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load
Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load Open
Working memory (WM) is a fundamental cognitive function crucial adaptive behavior. The intricate interplay between the frontal cortex and striatum in governing WM maintenance and updating remains a central question. In this study, we emplo…
View article: Programmable skyrmions for robust communication and intelligent sensing
Programmable skyrmions for robust communication and intelligent sensing Open
The recently observed plasmonic skyrmions, as electromagnetic counterparts of topologically stable quasiparticles, hold significant promise as novel carriers for robust information transfer and manipulation of nontrivial light-matter inter…
View article: 753 | FINAL ANALYSIS OF CONCORDANCE STUDY OF IMMUNOHISTOCHEMICAL CD30 EXPRESSION DETECTED BY NINE ASSAYS AND THE VENTANA CD30 ASSAY IN CHINESE LYMPHOMA PATIENTS (CREDIT STUDY)
753 | FINAL ANALYSIS OF CONCORDANCE STUDY OF IMMUNOHISTOCHEMICAL CD30 EXPRESSION DETECTED BY NINE ASSAYS AND THE VENTANA CD30 ASSAY IN CHINESE LYMPHOMA PATIENTS (CREDIT STUDY) Open
View article: 762 | ARTIFICIAL INTELLIGENCE‐ASSISTED QUANTITATIVE ANALYSIS FOR THE IMMUNOHISTOCHEMICAL EXPRESSION OF CD30 IN LYMPHOMAS
762 | ARTIFICIAL INTELLIGENCE‐ASSISTED QUANTITATIVE ANALYSIS FOR THE IMMUNOHISTOCHEMICAL EXPRESSION OF CD30 IN LYMPHOMAS Open
View article: Impact of Hemoglobin Glycation Index on Complications Following Orthopedic Surgery: A Retrospective Comparative Propensity Score‐Matched Study
Impact of Hemoglobin Glycation Index on Complications Following Orthopedic Surgery: A Retrospective Comparative Propensity Score‐Matched Study Open
Objective Patients with impaired glucose metabolism have an increased incidence of post‐operative complications. The best marker for glycemic control prior to elective orthopedic surgery remains unclear. We aimed to assess the utility of t…
View article: The U-curve associations of birth interval with prevalence of osteoarthritis in postmenopausal women
The U-curve associations of birth interval with prevalence of osteoarthritis in postmenopausal women Open
AFB, ALB and birth interval shown the U-shaped associations with OA prevalence in postmenopausal women with two deliveries. These findings highlight the potential long-term impacts of reproductive history on musculoskeletal health and may …
View article: Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration
Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration Open
Background Intervertebral disc degeneration (IDD) significantly contributes to low back pain (LBP), yet effective treatment options are scarce. BSHXF, a classical traditional Chinese medicine formula, demonstrates dual pharmacological acti…
View article: Mimicking nature's synergy: engineering FN3-based protein scaffolds for multi-enzyme assembly
Mimicking nature's synergy: engineering FN3-based protein scaffolds for multi-enzyme assembly Open
Multi-enzyme cascade reactions are common in nature. Compared to free-floating enzyme catalysis, enzyme co-localization, existing in some natural systems, can improve the efficiency of the reactions thanks to kinetic benefits. In engineeri…
View article: Comparison of the clinical outcomes and radiological parameters between the greater tuberosity strengthened proximal humeral plate and the proximal humeral internal locking system plate in the minimally invasive plate osteosynthesis treatment of proximal humeral fractures involving the greater tuberosity: a retrospective cohort study
Comparison of the clinical outcomes and radiological parameters between the greater tuberosity strengthened proximal humeral plate and the proximal humeral internal locking system plate in the minimally invasive plate osteosynthesis treatment of proximal humeral fractures involving the greater tuberosity: a retrospective cohort study Open
View article: Comparison of Patellar Tracking Following Kinematic Alignment Versus Mechanical Alignment Total Knee Arthroplasty via the Mini‐Subvastus Approach
Comparison of Patellar Tracking Following Kinematic Alignment Versus Mechanical Alignment Total Knee Arthroplasty via the Mini‐Subvastus Approach Open
Objectives Different alignment strategies (kinematic alignment [KA] versus mechanical alignment [MA]) during total knee arthroplasty (TKA) significantly influence postoperative patellar tracking. This study aimed to compare radiological pa…
View article: LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis
LncRNA MEG3 suppresses prostate cancer progression by mediating macrophage polarization via the miR-148a-3p/ARRDC3 signaling axis Open
Long-chain noncoding RNA (LncRNA) MEG3 significantly influences tumor microenvironment (TME) dynamics and macrophage polarization. However, its specific involvement in prostate cancer (PCa) progression remains unclear. MEG3 exhibited low e…
View article: Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1 Open
View article: Effect of perampanel in reducing depression in patients with focal epilepsy
Effect of perampanel in reducing depression in patients with focal epilepsy Open
Perampanel reduced depression symptoms in patients with focal epilepsy, although the lack of a control group or the relatively small sample size.
View article: Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC
Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC Open
Background Hepatocellular carcinoma (HCC) is one of the most prevalent causes of cancer-related morbidity and mortality worldwide. Late-stage detection and the complex molecular mechanisms driving tumor progression contribute significantly…
View article: Corrigendum to “Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways” [Ecotoxicol. Environ. Saf. 286 (2024) 117185]
Corrigendum to “Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways” [Ecotoxicol. Environ. Saf. 286 (2024) 117185] Open
View article: Study on the Effect of Longan Endophyte Fermentation broth on the Storage Quality of Passion Fruit
Study on the Effect of Longan Endophyte Fermentation broth on the Storage Quality of Passion Fruit Open
View article: Detection and Antimicrobial Susceptibility of Carbapenem‐Resistant Organisms Isolated in the Center of Care and Protection of Orphan Children, Vietnam
Detection and Antimicrobial Susceptibility of Carbapenem‐Resistant Organisms Isolated in the Center of Care and Protection of Orphan Children, Vietnam Open
Carbapenems are critical for treating patients infected with multidrug‐resistant bacteria; however, the use of carbapenems has also facilitated the selection and spreading of carbapenem‐resistant organisms (CROs), occasionally reported in …
View article: Granular Nanofiber‐Hydrogel Composite‐Programmed Regenerative Inflammation and Adipose Tissue Formation
Granular Nanofiber‐Hydrogel Composite‐Programmed Regenerative Inflammation and Adipose Tissue Formation Open
The interplay between biomaterials and host immune responses critically determines outcomes in tissue restoration. Recent studies suggest that physicochemical properties of materials can dictate pro‐regenerative versus pro‐fibrotic respons…
View article: Modified kinematic alignment better restores plantar pressure distribution than mechanical alignment in total knee arthroplasty: a randomized controlled trial
Modified kinematic alignment better restores plantar pressure distribution than mechanical alignment in total knee arthroplasty: a randomized controlled trial Open
View article: Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways
Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways Open
PCB126, a type of polychlorinated biphenyl (PCB), is a persistent pollutant found in both biotic and abiotic environments and poses significant public health risks due to its potential to cause cardiac damage with prolonged exposure. Hypox…
View article: TQB2450 with or without anlotinib as maintenance treatment in subjects with locally advanced/unresectable non-small cell lung cancer that have not progressed after prior concurrent/sequential chemoradiotherapy (R-ALPS): study protocol for a randomized, double-blind, placebo-controlled, multicenter phase III trial
TQB2450 with or without anlotinib as maintenance treatment in subjects with locally advanced/unresectable non-small cell lung cancer that have not progressed after prior concurrent/sequential chemoradiotherapy (R-ALPS): study protocol for a randomized, double-blind, placebo-controlled, multicenter phase III trial Open
Clinicaltrials.gov identifier: NCT04325763. Date of registration: May 27, 2020. Protocol version: Version 4.0, Sep 16, 2022 (https://classic.clinicaltrials.gov/ct2/show/NCT04325763).
View article: Use of a 2/3 Free Vascularized Fibula Flap for Tibiofibular Bone Defect Reconstruction
Use of a 2/3 Free Vascularized Fibula Flap for Tibiofibular Bone Defect Reconstruction Open
Case: A 40-year-old man with a tibiofibular bone defect caused by infection was treated using a 2/3 free vascularized fibula flap, which preserved 1/3 of the continuous periosteum and cortex of the fibula at the donor site, allowing for re…