Chenju Yi
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Astrocyte ezrin defines resilience to stress-induced depressive behaviours in mice Open
Astrocyte atrophy is the main histopathological hallmark of major depressive disorder (MDD) in humans and in animal models of depression. Here we demonstrated that manipulating with ezrin expression specifically in astrocytes significantly…
View article: Neuroglial Advances: New Roles for Established Players
Neuroglial Advances: New Roles for Established Players Open
Neuroglial cells perform numerous physiological functions and contribute to the pathogenesis of all diseases of the nervous system. Neuroglial neuroprotection defines the resilience of the nervous tissue to exo‐ and endogenous pathological…
Oligodendroglial precursor cells modulate immune response and early demyelination in a murine model of multiple sclerosis Open
Reproducing the pathophysiology of human multiple sclerosis (MS) in animal models is critical to identifying mechanisms triggering demyelination and to developing early intervention strategies. Here, we aimed to model overactivated Wnt (wi…
Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer’s disease Open
Our results highlighted that EPs can alleviate learning and memory impairments in AD with a gut microbiota-dependent manner and that butyric acid metabolized by butyric acid-metabolizing bacteria in the gut plays a central role in regulati…
Understanding glucose metabolism and insulin action at the blood–brain barrier: Implications for brain health and neurodegenerative diseases Open
The blood–brain barrier (BBB) is a highly selective, semipermeable barrier critical for maintaining brain homeostasis. The BBB regulates the transport of essential nutrients, hormones, and signaling molecules between the bloodstream and th…
View article: Global, regional, and national burdens of early-onset Alzheimer's disease and other dementias in women, 1990 to 2021
Global, regional, and national burdens of early-onset Alzheimer's disease and other dementias in women, 1990 to 2021 Open
Background Alzheimer's disease and other dementias disproportionally impacts women. Novel treatment makes understanding of early-onset cases unprecedentedly important. Objective We aimed to examine Alzheimer's disease and other dementias i…
View article: Turning microglia neuroprotective: Towards connexin43-specific therapy of Alzheimer’s disease
Turning microglia neuroprotective: Towards connexin43-specific therapy of Alzheimer’s disease Open
Alzheimer’s disease (AD) is the major cause of senile dementia without effective therapeutic strategies. The fundamental role of microglia in AD pathology, particularly in the early stages, is well acknowledged, although cell-specific ther…
Remyelination‐oriented clemastine treatment attenuates neuropathies of optic nerve and retina in glaucoma Open
As one of the top causes of blindness worldwide, glaucoma leads to diverse optic neuropathies such as degeneration of retinal ganglion cells (RGCs). It is widely accepted that the level of intraocular pressure (IOP) is a major risk factor …
Endothelial DR6 in blood-brain barrier malfunction in Alzheimer’s disease Open
The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in the early pathogenesis of Alzheimer’s disease (AD), prompting a focus on brain endothelial cells (BECs), which serve as the primary c…
Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics Open
Stress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the late…
Neuronal lysosome transfer to oligodendrocyte precursor cells: a novel mechanism of neuron-glia communication and its role in neurodegenerative diseases Open
Oligodendrocyte precursor cells (OPCs) shape brain function through intricate regulatory mechanisms. Here, we observed that OPC processes establish connections with neuronal somata, with smaller lysosomes positioned near these contact site…
Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease Open
Alzheimer’s disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailab…
Activation of Wnt/β‐catenin pathway in the brain endothelium mitigates Aβ‐induced blood‐brain barrier dysfunction in Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the leading cause of age‐related neurological and cognitive decline. As the mechanisms of this disease are yet to be fully understood, the treatments for AD pose a significant challenge. Dysfunction o…
Eucommiae cortex polysaccharides ameliorates learning and memory deficits in Alzheimer's disease mice by modulating gut microbiota and glutamate metabolism Open
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is distinguished by impairments in learning and memory. The microbiota-gut-brain axis has emerged as a significant factor in the pathogenesis of Alzheimer's disease. Euc…
Oligodendroglial precursors orchestrate immune network instigating early demyelination in experimental autoimmune encephalomyelitis Open
Summary The immunomodulatory cellular network that triggers early inflammation and demyelination, the key steps in multiple sclerosis (MS) pathogenesis remains poorly characterized. Here, we demonstrate that overactivation of Wnt pathway p…
Can biomarkers be used to diagnose attention deficit hyperactivity disorder? Open
Currently, the diagnosis of attention deficit hyperactivity disorder (ADHD) is solely based on behavioral tests prescribed by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). However, biomarkers can be more o…
Mitochondrial dysfunction in a rat model and the related risk of metabolic disorders. Open
KYD rats exhibited reduced mito-chondrial function in the brown fat, but were partially compensated by skeletal muscle, associated with the phenotype of warm preference and metabolic disorder, which was further exacerbated by additional HF…
The effects of exercise with nicotine replacement therapy for smoking cessation in adults: A systematic review Open
Objective This systematic review aimed to evaluate the efficacy of exercise programmes with nicotine replacement therapy (NRT) for smoking cessation in adults. Introduction Nicotine addiction is mediated by dopamine. Exercise can also acti…
Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease Open
Alzheimer’s disease is a neurodegenerative disorder that causes age-dependent neurological and cognitive declines. The treatments for Alzheimer’s disease pose a significant challenge, because the mechanisms of disease are not being fully u…
In-utero exposure to air pollution and early-life neural development and cognition Open
Air pollution remains one of the major health threats around the world. Compared to adults, foetuses and infants are more vulnerable to the effects of environmental toxins. Maternal exposure to air pollution causes several adverse birth ou…