Chenmala Karthika
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View article: Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach
Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach Open
A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various phy…
View article: 5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters
5-Fluorouracil and Curcumin Combination Coated with Pectin and Its Strategy towards Titanium Dioxide, Dimethylhydrazine Colorectal Cancer Model with the Evaluation of the Blood Parameters Open
Colorectal cancer is considered the third most common cancer and the second leading cause of death globally. It has been proven that titanium dioxide nanoparticles produce oxidative stress and can lead to chronic inflammation, which could …
View article: Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein
Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein Open
P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells. P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer medicines and confers resistance. Due to its wide specif…
View article: Multidrug Resistance in Cancer Cells: Focus on a Possible Strategy Plan to Address Colon Carcinoma Cells
Multidrug Resistance in Cancer Cells: Focus on a Possible Strategy Plan to Address Colon Carcinoma Cells Open
Even though various treatment methods are available for cancer, the death curve is not reducing. The diagnosis of cancer at the fourth stage and drug resistance are the leading reasons for treatment failure and lower survival rates. In thi…
View article: A Background Search on the Potential Role of <i>Scutellaria</i> and Its Essential Oils
A Background Search on the Potential Role of <i>Scutellaria</i> and Its Essential Oils Open
Scutellaria (Lamiaceae), which contains over 350 species, usually known as skullcaps, is found throughout Europe, the United States, and East Asia. In traditional Chinese medicine, several species are used to wipe out heat‐evil and remove …
View article: 5-Fluorouracil And Curcumin With Pectin Coating As a Treatment Regimen For Titanium Dioxide Induced Colon Cancer Model
5-Fluorouracil And Curcumin With Pectin Coating As a Treatment Regimen For Titanium Dioxide Induced Colon Cancer Model Open
Objective: Induction of colorectal cancer in Wister rats using titanium dioxide and dimethylhydrazine and treatment using the physical conjugate of 5-Fluorouracil and Curcumin, with a synergistic approach. Methods : Compatibility studies a…
View article: Chemo-Preventive Action of Resveratrol: Suppression of p53—A Molecular Targeting Approach
Chemo-Preventive Action of Resveratrol: Suppression of p53—A Molecular Targeting Approach Open
Extensive experimental, clinical, and epidemiological evidence has explained and proven that products of natural origin are significantly important in preventing and/or ameliorating various disorders, including different types of cancer th…
View article: Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets
Curcumin Nanoparticles as Promising Therapeutic Agents for Drug Targets Open
Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across the globe for its therapeutic and medicinal benefits. The active moiety of Curcuma longa is curcumin and has gained importance in vario…
View article: Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer
Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer Open
Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nut…
View article: WILL THE TRADITIONAL MEDICINE UN-PAUSE THE WORLD AND DECIDE THE FATE OF COVID-19?
WILL THE TRADITIONAL MEDICINE UN-PAUSE THE WORLD AND DECIDE THE FATE OF COVID-19? Open
COVID-19 is a life-threatening disease that mainly affects the human respiratory system. In today’s world, scientists are working conscientiously for the identification of promising drugs and vaccines. But, when we look back to the former …
View article: P-Glycoprotein Efflux Transporters and Its Resistance Its Inhibitors and Therapeutic Aspects
P-Glycoprotein Efflux Transporters and Its Resistance Its Inhibitors and Therapeutic Aspects Open
P-glycoprotein (P-gp) is an active member of the ATP Binding Cassette (ABC) protein subfamily which effluxes a wide range of therapeutic drugs out of the cells commonly known as multidrug resistance. But its protective action towards the n…
View article: Lipid-Based Nano Formulation Approach to Target Brain for the Management of Tuberculosis through Intranasal Delivery: Formulation Development and Evaluation
Lipid-Based Nano Formulation Approach to Target Brain for the Management of Tuberculosis through Intranasal Delivery: Formulation Development and Evaluation Open
Objectives: Development of nano-emulsion based drug delivery as combined drug loaded form for the possible management of meningitis. Intranasal delivery of nano-emulsion to the brain and study the nasal irritancy. Methodology: Spontaneous …
View article: A Forecast on Strategies for Regulatory Requirement of Drug Product Registration in African Pharmaceutical
A Forecast on Strategies for Regulatory Requirement of Drug Product Registration in African Pharmaceutical Open
Generics are playing a vigorous role in human health. As there is a widespread growth in population, demand for different disease types have also been increased and where drug players are concentrating for newest design, growth and profit.…
View article: FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF CURCUMIN-LOADED SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR COLON CARCINOMA
FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF CURCUMIN-LOADED SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR COLON CARCINOMA Open
Objective: Cancer is the deadliest disease affecting the life of the people all around the world. Colon cancer is the cancer which is affecting the colon region it is the last part of the gastrointestinal tract which is mainly responsible …
View article: Study on Formulation development and shelf life indicating stability of Artesunate loaded Self-nanoemulsifying Drug Delivery System
Study on Formulation development and shelf life indicating stability of Artesunate loaded Self-nanoemulsifying Drug Delivery System Open
Solubility plays an important role in the formulation. When a drug is poorly soluble, their bioavailability will be affected. However, the solubility of the drug can be enhanced by using various methods like pharmaceutical approach, pharma…
View article: Formulation Development and <i>In vitro</i> Characterization of Solid Self Nano Emulsifying Drug Delivery System for Curcumin to Target Colon Adenocarcinoma
Formulation Development and <i>In vitro</i> Characterization of Solid Self Nano Emulsifying Drug Delivery System for Curcumin to Target Colon Adenocarcinoma Open
Cancer is the abnormal growth of cells in any part of the body; where when we are considering the Indian scenario, colon cancer stand to be forth in men and third in woman with the respect to mortality and incidence rate. The different dos…