Chenqi Tang
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View article: FGF7 promotes load-bearing tendon regeneration and suppresses fibrosis
FGF7 promotes load-bearing tendon regeneration and suppresses fibrosis Open
Tissue fibrosis is a major cause of organ dysfunction. Preventing fibrosis in tissue pathological condition remains a significant clinical challenge. Here we investigate the role of fibroblast growth factor 7 (FGF7) in mitigating fibrosis …
View article: Classification of distinct tendinopathy subtypes for precision therapeutics
Classification of distinct tendinopathy subtypes for precision therapeutics Open
Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification o…
View article: A retrospective study of inpatients diagnosed with degloving skin and soft tissue injuries
A retrospective study of inpatients diagnosed with degloving skin and soft tissue injuries Open
The overall picture of degloving skin and soft tissue injuries (DSTI) remains a blank space in China. Therefore, a retrospective study was designed to summarize the current situation of this injury. Patients diagnosed with DSTI hospitalize…
View article: Stem cell-based therapeutic strategies for rotator cuff tendinopathy
Stem cell-based therapeutic strategies for rotator cuff tendinopathy Open
This review explores the optimal sources of stem cells for rotator cuff tendinopathy and the principles for selecting stem cell dosages. Key strategies are provided for stem cell population standardization and recipient selection.
View article: A multi-screen collaboration-based low-cost portable dry-lab simulator for basic laparoscopic skills training: A technical note
A multi-screen collaboration-based low-cost portable dry-lab simulator for basic laparoscopic skills training: A technical note Open
Laparoscopic skills training has always been crucial for novice surgeons. Readily accessible equipment, as well as structured training curriculum should be provided to guarantee adequate practice hours and skill proficiency. Dry-lab traini…
View article: An Overview of the Current Situation of Degloving Skin and Soft-Tissue Injuries in China: A Retrospective Study of the Inpatients with DSTI from 2013 to 2018
An Overview of the Current Situation of Degloving Skin and Soft-Tissue Injuries in China: A Retrospective Study of the Inpatients with DSTI from 2013 to 2018 Open
Background: Degloving skin and soft-tissue injury (DSTI) is a kind of serious lesion in the field of surgery, with potential risk of morbidity and mortality. This study is aimed to summarize and analyze the current situation of DSTI in Chi…
View article: Non-muscle myosin II knockdown improves survival and therapeutic effects of implanted bone marrow-derived mesenchymal stem cells in lipopolysaccharide-induced acute lung injury
Non-muscle myosin II knockdown improves survival and therapeutic effects of implanted bone marrow-derived mesenchymal stem cells in lipopolysaccharide-induced acute lung injury Open
NM-II knockdown could inhibit the apoptosis of implanted BMSCs in lung tissues and improve its self-renewal activity. NM-II siRNA-modified BMSCs have a slightly enhanced ability to attenuate lung injury after LPS challenge.
View article: An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells
An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells Open
Articular cartilage focal lesion remains an intractable challenge in sports medicine, and autologous chondrocytes' implantation (ACI) is one of the most commonly utilized treatment modality for this ailment. However, the current ACI techni…
View article: Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification
Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification Open
We revealed the importance of mTOR in tendon HO and established a drug delivery system that targets pathological collagen.
View article: Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages
Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages Open
Meniscus-derived stem cells (MeSCs) are a potential cell source for meniscus tissue engineering. The stark morphological and structural changes of meniscus tissue during development indicate the complexity of MeSCs at different tissue regi…
View article: Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention
Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention Open
Current surgical management of anterior cruciate ligament (ACL) rupture still remains an intractable challenge in ACL regeneration due to the weak self-healing capability of ACL. Inadequate cell numbers and vascularization within the artic…