Chenran Zhang
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View article: Stroke burden analysis attributable to ambient and household PM2.5 in China from 1990 to 2021 based on GBD 2021
Stroke burden analysis attributable to ambient and household PM2.5 in China from 1990 to 2021 based on GBD 2021 Open
View article: Global burden of ischemic heart disease attributable to ambient and household PM2.5 exposure: a comprehensive analysis (1990–2021) from socioeconomics perspective
Global burden of ischemic heart disease attributable to ambient and household PM2.5 exposure: a comprehensive analysis (1990–2021) from socioeconomics perspective Open
Objectives Socioeconomic status links to exposure of air pollutants. This study evaluates global PM 2.5 -attributable ischemic heart disease (IHD) burden from 1990 to 2021. Methods Using Global Burden of Disease (GBD) 2021 data, PM 2.5 -re…
View article: miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression
miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression Open
View article: Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin
Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin Open
View article: Data from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
Data from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy Open
Increased recruitment of tumor-associated macrophages (TAM) to tumors following chemotherapy promotes tumor resistance and recurrence and correlates with poor prognosis. TAM depletion suppresses tumor growth, but is not highly effective du…
View article: Supplementary Materials from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
Supplementary Materials from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy Open
The Supplementary Materials file contains the following: 1) Supplementary Methods; 2) Supplementary Fig. S1: structure and characterizations of GO(HPPH)-PEG; 3) Supplementary Fig. S2: in vitro stability of GO(HPPH)-PEG; 4) Supplementary Fi…
View article: Supplementary Materials from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
Supplementary Materials from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy Open
The Supplementary Materials file contains the following: 1) Supplementary Methods; 2) Supplementary Fig. S1: structure and characterizations of GO(HPPH)-PEG; 3) Supplementary Fig. S2: in vitro stability of GO(HPPH)-PEG; 4) Supplementary Fi…
View article: Data from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy
Data from Chemotherapy-Induced Macrophage Infiltration into Tumors Enhances Nanographene-Based Photodynamic Therapy Open
Increased recruitment of tumor-associated macrophages (TAM) to tumors following chemotherapy promotes tumor resistance and recurrence and correlates with poor prognosis. TAM depletion suppresses tumor growth, but is not highly effective du…
View article: Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin
Expression profiling of N6-methyladenosine-modified mRNA in PC12 cells in response to unconjugated bilirubin Open
Background Abnormal methylation of N 6 -methyladenosine (m 6 A) is reportedly associated with central nervous system disorders. However, the role of m 6 A mRNA methylation in unconjugated bilirubin (UCB) neurotoxicity needs to be further u…
View article: Publisher Correction: Electrochemical biosensing of circulating microRNA-21 in cerebrospinal fluid of medulloblastoma patients through target-induced redox signal amplification
Publisher Correction: Electrochemical biosensing of circulating microRNA-21 in cerebrospinal fluid of medulloblastoma patients through target-induced redox signal amplification Open
View article: Establishment of a prognostic-related microRNAs risk model for glioma by bioinformatics analysis
Establishment of a prognostic-related microRNAs risk model for glioma by bioinformatics analysis Open
Seven miRNAs which regulate target genes to participate in related signaling pathways and lead to a poor prognosis were identified as biomarkers of glioma.
View article: Hypoxia- and dexamethasone-dependent HIF1α-glucocorticoid receptor interaction leads to degradation of glucocorticoid receptor in pituitary adenomas.
Hypoxia- and dexamethasone-dependent HIF1α-glucocorticoid receptor interaction leads to degradation of glucocorticoid receptor in pituitary adenomas. Open
Cushing disease has a very high mortality rate and glucocorticoid resistance caused by GR down-regulation is one major reason of mortality. Although HIF1α signaling and GR signaling are involved in the pathogenesis of pituitary adenomas, i…
View article: Challenges and opportunities for managing pediatric central nervous system tumors in China
Challenges and opportunities for managing pediatric central nervous system tumors in China Open
Central nervous system (CNS) tumors represent the most deadly cancer in pediatric age group. In China, thousands of children are diagnosed with CNS tumors every year. Despite the improving socioeconomic status and availability of medical e…
View article: Enhanced efficacy of histone deacetylase inhibitor panobinostat combined with dual PI3K/mTOR inhibitor BEZ235 against glioblastoma.
Enhanced efficacy of histone deacetylase inhibitor panobinostat combined with dual PI3K/mTOR inhibitor BEZ235 against glioblastoma. Open
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite multiple treatment strategies, the prognosis is still poor. This study aimed to evaluate the efficacy of combination treatment of GBM with the histon…
View article: CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo
CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo Open
Our study shows that targeting SE-associated transcription addiction by CDK7 inhibition could be an effective therapeutic strategy against GBM.
View article: Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma
Enhanced efficacy of histone deacetylase inhibitor combined with bromodomain inhibitor in glioblastoma Open
View article: Methylation Status of the RIZ1 Gene Promoter in Human Glioma Tissues and Cell Lines
Methylation Status of the RIZ1 Gene Promoter in Human Glioma Tissues and Cell Lines Open
View article: RLIP76 Depletion Enhances Autophagic Flux in U251 Cells
RLIP76 Depletion Enhances Autophagic Flux in U251 Cells Open
View article: RIZ1: a potential tumor suppressor in glioma
RIZ1: a potential tumor suppressor in glioma Open
View article: Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells
Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells Open
View article: Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer
Molecular Imaging of Tumor-Infiltrating Macrophages in a Preclinical Mouse Model of Breast Cancer Open
Significant evidence has indicated that tumor-associated macrophages (TAMs) play a critical role in the proliferation, invasion, angiogenesis, and metastasis of a variety of human carcinomas. In this study, we investigated whether near-inf…