Chenting Zhang
YOU?
Author Swipe
View article: Development and evaluation of a prognosis prediction model for hepatocellular carcinoma via multiomics integration and semisupervised machine learning
Development and evaluation of a prognosis prediction model for hepatocellular carcinoma via multiomics integration and semisupervised machine learning Open
Hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) is a malignant tumor caused primarily by chronic hepatitis B virus infection and accounts for 75.09% of all HCC cases in China. However, treatment efficacy is low when the regime…
View article: Identification of Oxidative Stress-Related Shared Biomarkers in Vitiligo and Periodontitis: A Bioinformatics and Machine Learning Study
Identification of Oxidative Stress-Related Shared Biomarkers in Vitiligo and Periodontitis: A Bioinformatics and Machine Learning Study Open
Our study has identified PTGS2, CCL5, and PRDX4 as key biomarkers for vitiligo and periodontitis, two diseases linked by similar immune infiltration patterns. These biomarkers offer new diagnostic insights and potential therapeutic targets.
View article: Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups
Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups Open
View article: A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis
A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis Open
Background: The causal relationship between various prevalent autoimmune diseases (ADs) and pulmonary hypertension (PH) has yet to be fully understood, and the contribution of genetic factors to their coexistence remains largely une…
View article: Predicting nasal diseases based on microbiota relationship network
Predicting nasal diseases based on microbiota relationship network Open
Objectives Increasing evidence indicates that the local microbiome can be used to predict host disease states. However, constructing models that obtain better results with fewer features is still challenging. Methods In this study, we esta…
View article: Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats
Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats Open
View article: Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease
Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease Open
View article: Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats
Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats Open
Background：Pulmonary hypertension (PH) is a common complication in patients with chronic kidney disease (CKD), affecting prognosis. However, the pathogenesis is not clear, and the lack of a stable animal model is a significant factor. Meth…
View article: Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats
Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats Open
Background Pulmonary hypertension (PH) is a common complication in patients with chronic kidney disease (CKD), affecting prognosis. However, the pathogenesis is not clear, and the lack of a stable animal model is a significant factor. Meth…
View article: Impacts of anaesthesia strategies on mouth–lung microbial signature: Evidence from bronchoscopy sampling and sequencing
Impacts of anaesthesia strategies on mouth–lung microbial signature: Evidence from bronchoscopy sampling and sequencing Open
Dear Editor, Bronchoscopy has become a well-established strategy for the diagnosis and treatment of lung diseases and is commonly used in pathological assessment and biopsy. Bronchoscopy can be operated under either general or local anaest…
View article: Review of Structural Fire Hazards, Challenges, and Prevention Strategies
Review of Structural Fire Hazards, Challenges, and Prevention Strategies Open
Reducing the occurrence of structural fires is the common goal of all countries. However, the development level of different countries determines the degree of perfection of local fire management regulations. Developed countries have a mor…
View article: Respiratory Microbiome Profile of Pediatric Pulmonary Hypertension Patients Associated With Congenital Heart Disease
Respiratory Microbiome Profile of Pediatric Pulmonary Hypertension Patients Associated With Congenital Heart Disease Open
Background: Pulmonary hypertension (PH) associated with congenital heart disease (CHD) is the most common type of PH in pediatric patients. The airway microbiome profile in CHD-PH patients remains rarely studied. Methods: A total of 158 ch…
View article: Visibility, wind speed, and dew point temperature are important factors in SARS‐CoV‐2 transmissibility
Visibility, wind speed, and dew point temperature are important factors in SARS‐CoV‐2 transmissibility Open
The aim of this study is to provide evidence for the influencing factors of severe acute respiratory syndrome coronavirus 2 (SARS‐COV‐2) virus mutation by determining the impact of geographical and meteorological factors on SARS‐CoV‐2 tran…
View article: Upregulation of Mechanosensitive Channel Piezo1 Involved in High Shear Stress-induced Pulmonary Hypertension
Upregulation of Mechanosensitive Channel Piezo1 Involved in High Shear Stress-induced Pulmonary Hypertension Open
Background and Purpose: Piezo1 is a crucial mechanical sensitive channel involved in vascular remodeling. However, the role of Piezo1 in different types of vascular cells during the development of pulmonary hypertension (PH) induced by hig…
View article: Established pulmonary hypertension in rats was reversed by a combination of a HIF‐2α antagonist and a p53 agonist
Established pulmonary hypertension in rats was reversed by a combination of a HIF‐2α antagonist and a p53 agonist Open
Background and Purpose Recent studies reported therapeutic effects of monotherapy with either tumour suppressor p53 (p53) agonist or hypoxia‐inducible factor 2α (HIF‐2α) antagonist for pulmonary hypertension (PH). This study investigated w…
View article: The causality between CFTR and pulmonary hypertension: insights from Mendelian randomization studies
The causality between CFTR and pulmonary hypertension: insights from Mendelian randomization studies Open
View article: Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients Open
Emerging studies have reported the mechanosensitive Piezo1 (piezo type mechanosensitive ion channel component 1) plays essential roles in regulating the vascular tone through mechanistic actions on intracellular calcium homeostasis. Howeve…
View article: Mitomycin C induces pulmonary vascular endothelial‐to‐mesenchymal transition and pulmonary veno‐occlusive disease via Smad3‐dependent pathway in rats
Mitomycin C induces pulmonary vascular endothelial‐to‐mesenchymal transition and pulmonary veno‐occlusive disease via Smad3‐dependent pathway in rats Open
Background and Purpose Pulmonary veno‐occlusive disease (PVOD) is a rare disease characterized by the obstruction of small pulmonary veins leading to pulmonary hypertension. However, the mechanisms underlying pulmonary vessel occlusion rem…
View article: Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats
Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats Open
Background and Purpose Pulmonary hypertension related to pulmonary fibrosis is classed as WHO Group III, one of the most common groups which lacks effective treatment options. In this study, we aimed to uncover the underlying mechanisms, p…
View article: Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension
Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension Open
Alteration in microbiota composition of respiratory tract has been reported in the progression of many chronic lung diseases, yet, the correlation and causal link between respiratory tract microbiota and the disease development of pulmonar…
View article: Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition
Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition Open
For decades, stem cell therapies for pulmonary hypertension (PH) have progressed from laboratory hypothesis to clinical practice. Promising preclinical investigations have laid both a theoretical and practical foundation for clinical appli…
View article: Author Correction: Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model
Author Correction: Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View article: Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension
Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension Open
The tumor-suppressive role of p53, a transcription factor that regulates the expression of many genes, has been linked to cell cycle arrest, apoptosis, and senescence. The noncanonical function or the pathogenic role of p53 has more recent…
View article: Establishment and evaluation of chronic obstructive pulmonary disease model by chronic exposure to motor vehicle exhaust combined with lipopolysaccharide instillation
Establishment and evaluation of chronic obstructive pulmonary disease model by chronic exposure to motor vehicle exhaust combined with lipopolysaccharide instillation Open
New Findings What is the central question of this study? In this study, by using motor vehicle exhaust (MVE) exposure with or without lipopolysaccharide (LPS) instillation, we established, evaluated and compared MVE, LPS and MVE+LPS treatm…
View article: Nicotine enhances store‑operated calcium entry by upregulating HIF‑1α and SOCC components in non‑small cell lung cancer cells
Nicotine enhances store‑operated calcium entry by upregulating HIF‑1α and SOCC components in non‑small cell lung cancer cells Open
Store‑operated calcium entry (SOCE) is critical for regulating the proliferation and metastasis of various cancer types. The present study aimed to investigate the role of SOCE on nicotine‑promoted proliferation of non‑small cell lung canc…
View article: Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model
Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model Open
View article: Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway
Sodium Tanshinone IIA Sulfonate Decreases Cigarette Smoke-Induced Inflammation and Oxidative Stress via Blocking the Activation of MAPK/HIF-1α Signaling Pathway Open
Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and promotes oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD). The present study investigated whether sodium tanshinone IIA…
View article: Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD [Corrigendum]
Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD [Corrigendum] Open
[This corrects the article on p. 581 in vol. 12, PMID: 28260872.].
View article: Pharmacological activation of PPARγ inhibits hypoxia-induced proliferation through a caveolin-1-targeted and -dependent mechanism in PASMCs
Pharmacological activation of PPARγ inhibits hypoxia-induced proliferation through a caveolin-1-targeted and -dependent mechanism in PASMCs Open
Previously, we and others have demonstrated that activation of peroxisome proliferator-activated receptor γ (PPARγ) by specific pharmacological agonists inhibits the pathogenesis of chronic hypoxia-induced pulmonary hypertension (CHPH) by …
View article: Sputum mucin 1 is increased during the acute phase of chronic obstructive pulmonary disease exacerbation
Sputum mucin 1 is increased during the acute phase of chronic obstructive pulmonary disease exacerbation Open
Unlike pure bacterial induced lung inflammation, both sputum MUC1 CT and EC fragments are increased during acute exacerbation of COPD. The clinical benefits from measuring the changes of various sputum MUC1 fragments in AECOPD need to be e…