Caiyun Fang
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View article: Associations Between Milk Composition, Blood Metabolomics, and Systemic Physiological Indices in High- vs. Low-Yielding Guanzhong Dairy Goats During Early Lactation
Associations Between Milk Composition, Blood Metabolomics, and Systemic Physiological Indices in High- vs. Low-Yielding Guanzhong Dairy Goats During Early Lactation Open
This study aimed to elucidate the intrinsic regulatory mechanisms by comparing milk quality, blood metabolomics, and physiological indices between high-yielding (BH, n = 15, high milk yield, daily milk yield with 4.08 ± 0.17 kg) and low-yi…
View article: Development and Validation of a Cross-Device Platform for Anhedonia Trend Visualization Using Ecological Momentary Assessment and Moving Averages (Part I): Protocol for a Methodological Pilot Study (Preprint)
Development and Validation of a Cross-Device Platform for Anhedonia Trend Visualization Using Ecological Momentary Assessment and Moving Averages (Part I): Protocol for a Methodological Pilot Study (Preprint) Open
View article: Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury
Biomimetic polymersomal nanoreactors for hepatocyte-directed detoxification in drug-induced liver injury Open
View article: Soil types create different rhizosphere ecosystems and profoundly affect the growth characteristics of ratoon sugarcane
Soil types create different rhizosphere ecosystems and profoundly affect the growth characteristics of ratoon sugarcane Open
Introduction Rhizosphere ecological factors play a crucial role in the soil feedback function of ratoon sugarcane. However, limited information exists regarding the differences and relationships among these factors across various soil type…
View article: The therapeutic effect of Berberine on rodent models of kidney injury: a systematic review and meta - analysis
The therapeutic effect of Berberine on rodent models of kidney injury: a systematic review and meta - analysis Open
The beneficial effects of berberine in AKI are likely attributed to its diverse mechanisms, including antioxidant, anti-inflammatory pathways. However, to accurately delineate the efficacy and safety of berberine as a therapeutic intervent…
View article: In-field nucleic acid testing for porcine epidemic diarrhea virus with lateral flow immunoassay
In-field nucleic acid testing for porcine epidemic diarrhea virus with lateral flow immunoassay Open
Porcine epidemic diarrhea is a significant disease that damages the global pig industry. The delay between infection and vaccination allows for a 30–70% mortality rate among piglets. Early virus detection is a more effective disease manage…
View article: The Multi-Agentization of a Dual-Arm Nursing Robot Based on Large Language Models
The Multi-Agentization of a Dual-Arm Nursing Robot Based on Large Language Models Open
Nursing robots are designed to serve users, and their ability to interact with humans, as well as to make task-related decisions and decompositions based on such interactions, is a fundamental prerequisite for autonomous execution of nursi…
View article: Tumor cells targetable graphene oxide doped microneedle for synergistic photothermal-chemotherapy treatment of melanoma
Tumor cells targetable graphene oxide doped microneedle for synergistic photothermal-chemotherapy treatment of melanoma Open
View article: Meta-analysis of berberine (Berberine) in an animal model of kidney injury
Meta-analysis of berberine (Berberine) in an animal model of kidney injury Open
View article: The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus
The Role of Placental MFF-Mediated Mitochondrial Fission in Gestational Diabetes Mellitus Open
Our study demonstrates that MFF-mediated mitochondrial fission inhibits insulin sensitivity and upregulates glucose transport in GDM, which is related to offspring exposure to a hyperglycemic intrauterine environment. These results provide…
View article: Dissolving Microneedles with Plant-Derived Vesicles for Synergistic Chemo-Photothermal Delivery in Cutaneous Squamous Cell Carcinoma Therapy
Dissolving Microneedles with Plant-Derived Vesicles for Synergistic Chemo-Photothermal Delivery in Cutaneous Squamous Cell Carcinoma Therapy Open
View article: ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation Open
LMNA gene mutation can cause muscular dystrophy, and post-translational modification plays a critical role in regulating its function. Here, we identify that lamin A is palmitoylated at cysteine 522, 588, and 591 residues, which are revers…
View article: A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions
A peptidic inhibitor for PD-1 palmitoylation targets its expression and functions Open
We show for the first time that PD-1 is palmitoylated, identify DHHC9 as the predominant enzyme for its palmitoylation, and reveal the molecular mechanisms underlying its effects on PD-1 stability and functions. Importantly, we also design…
View article: Palmitoylation is critically required for cancer intrinsic PD-1 expression and functions
Palmitoylation is critically required for cancer intrinsic PD-1 expression and functions Open
Programmed cell death protein 1 (PD-1) is a crucial anticancer target, but the relatively low response rate and acquired resistance to existing antibody drugs highlight an urgent need to develop alternative targeting strategies. Here we re…
View article: Author Correction: Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours
Author Correction: Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours Open
View article: PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1
PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1 Open
View article: Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator
Affinity Purification of the Hepatitis C Virus Replicase Identifies Valosin-Containing Protein, a Member of the ATPases Associated with Diverse Cellular Activities Family, as an Active Virus Replication Modulator Open
Like almost all of the positive-strand RNA viruses, hepatitis C virus (HCV) induces host intracellular membrane modification to form the membrane-bound viral replication complex (RC), within which viral replicases amplify the viral RNA gen…
View article: Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics
Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics Open
Colorectal cancer (CRC) represents the third most common cancer in males and second in females worldwide. Here, we performed a quantitative 8-plex iTRAQ proteomics analysis of the secreted proteins from five colonic fibroblast cultures and…