Tao Chang
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View article: Immunotherapy With Programmed Cell Death 1 Versus Programmed Cell Death Ligand 1 Inhibitors in Patients With Advanced Non–Small Cell Lung Cancers: A Multicenter, Retrospective Analysis
Immunotherapy With Programmed Cell Death 1 Versus Programmed Cell Death Ligand 1 Inhibitors in Patients With Advanced Non–Small Cell Lung Cancers: A Multicenter, Retrospective Analysis Open
This multicenter retrospective study analyzed data from 1266 patients with advanced non–small cell lung cancer (NSCLC) across five leading hospitals in China. The aim was to evaluate survival outcomes and safety profiles of programmed cell…
View article: The impact of maximized resection and standardized systemic therapy on overall survival in adult patients with thalamic gliomas
The impact of maximized resection and standardized systemic therapy on overall survival in adult patients with thalamic gliomas Open
Objective This study aims to explore the impact of maximized resection and standardized systemic surgery + chemoradiotherapy(SRC) on the survival prognosis of adult thalamic glioma, and to construct a clinical prognosis model of adult thal…
View article: 2024 EAU/ESPU paediatric urology guidelines: key updates on congenital lower urinary tract obstruction and clinical inter-pretation
2024 EAU/ESPU paediatric urology guidelines: key updates on congenital lower urinary tract obstruction and clinical inter-pretation Open
Congenital lower urinary tract obstruction (CLUTO) is a spectrum of fetal malformations caused by anatomical abnormalities of the urethra, characterized by high rates of perinatal complications and mortality. The 2024 joint guideline from …
View article: Dihydromyricetin protects against cisplatin-induced renal injury and mitochondria-mediated apoptosis via the EGFR/HSP27/STAT3 signaling pathway
Dihydromyricetin protects against cisplatin-induced renal injury and mitochondria-mediated apoptosis via the EGFR/HSP27/STAT3 signaling pathway Open
DHM effectively inhibited CP-induced oxidative stress, inflammation, and mitochondria-mediated apoptosis through the EGFR/HSP27/STAT3 pathway.
View article: Developing a predictive model and uncovering immune influences on prognosis for brain metastasis from lung carcinomas
Developing a predictive model and uncovering immune influences on prognosis for brain metastasis from lung carcinomas Open
Objective Primary lung carcinomas (LCs) often metastasize to the brain, resulting in a grim prognosis for affected individuals. This population-based study aimed to investigate their survival period and immune status, while also establishi…
View article: Medium- and long-term outcomes of tunneled labial mucosa tube grafts for the repair of primary severe hypospadias and failed hypospadias
Medium- and long-term outcomes of tunneled labial mucosa tube grafts for the repair of primary severe hypospadias and failed hypospadias Open
Objective This study aimed to evaluate the medium and long-term outcomes of tunneled labial mucosa tube graft urethroplasty in the treatment of primary severe hypospadias and failed hypospadias. Methods We retrospectively reviewed the medi…
View article: Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non‐Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non‐Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production Open
Targeting oxidative phosphorylation (OXPHOS) through inhibiting the electron transport chain (ETC) has shown promising pre‐clinical efficacy in cancer therapy. Although aerobic glycolysis is a hallmark of cancer, emerging evidence suggest …
View article: 61 - The Diagnostic Role of Prostatic Urethral Angle in Diagnosis of Bladder Neck Dysfunction in Men with LUTS and Small Total Prostate Volume
61 - The Diagnostic Role of Prostatic Urethral Angle in Diagnosis of Bladder Neck Dysfunction in Men with LUTS and Small Total Prostate Volume Open
View article: Variable screening and model construction for prognosis of elderly patients with lower-grade gliomas based on LASSO-Cox regression: a population-based cohort study
Variable screening and model construction for prognosis of elderly patients with lower-grade gliomas based on LASSO-Cox regression: a population-based cohort study Open
Background This study aimed to identify prognostic factors for survival and develop a prognostic nomogram to predict the survival probability of elderly patients with lower-grade gliomas (LGGs). Methods Elderly patients with histologically…
View article: Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas
Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas Open
Background The clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale, population-based study aimed to comprehensively outline these traits and construct a predictive model.…
View article: Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas
Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas Open
Background The clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been well explored. This large-scale population-based study aimed to comprehensively outline these traits and construct a predictive model. Method…
View article: Alterations of electrocortical activity during hand movements induced by motor cortex glioma
Alterations of electrocortical activity during hand movements induced by motor cortex glioma Open
Glioma cells can reshape functional neuronal networks by hijacking neuronal synapses, leading to partial or complete neurological dysfunction. These mechanisms have been previously explored for language functions. However, the impact of gl…
View article: Simulation to become a better neurosurgeon. An international prospective controlled trial: The Passion study
Simulation to become a better neurosurgeon. An international prospective controlled trial: The Passion study Open
A brief and intensive training regimen utilizing 3D virtual reality simulators enhances residents' microsurgical proficiency in brain tumour removal models. Simulators emerge as a viable tool to expedite the learning curve of in-training n…
View article: Retraction Note: Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3
Retraction Note: Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3 Open
View article: Markov Chain-Guided Graph Construction and Sampling Depth Optimization for EEG-Based Mental Disorder Detection
Markov Chain-Guided Graph Construction and Sampling Depth Optimization for EEG-Based Mental Disorder Detection Open
Graph Neural Networks (GNNs) have received considerable attention since its introduction. It has been widely applied in various fields due to its ability to represent graph structured data. However, the application of GNNs is constrained b…
View article: Prognostic nomogram models for predicting survival probability in elderly glioblastoma patients
Prognostic nomogram models for predicting survival probability in elderly glioblastoma patients Open
View article: PAQR5 Expression Is Suppressed by TGFβ1 and Associated With a Poor Survival Outcome in Renal Clear Cell Carcinoma
PAQR5 Expression Is Suppressed by TGFβ1 and Associated With a Poor Survival Outcome in Renal Clear Cell Carcinoma Open
Background Renal cell carcinoma (RCC) was sex-hormone responsive, and clinical trials using progesterone significantly reduced the incidence of distal metastasis after radical nephrectomy. Recently membrane-bound progesterone receptors (mP…
View article: Surgical management and molecular diagnosis of persistent Müllerian duct syndrome in Chinese patients
Surgical management and molecular diagnosis of persistent Müllerian duct syndrome in Chinese patients Open
Persistent Müllerian duct syndrome (PMDS) is a rare clinically and genetically overlapping disorder caused by mutations in the anti-Müllerian hormone ( AMH ) gene or the anti-Müllerian hormone receptor type 2 ( AMHR2 ) gene. Affected indiv…
View article: Noninvasive evaluation of intracranial pressure in patients with traumatic brain injury by transcranial Doppler ultrasound
Noninvasive evaluation of intracranial pressure in patients with traumatic brain injury by transcranial Doppler ultrasound Open
Introduction The purpose of this study was to investigate the relationship between pulsatility index (PI) or optic nerve sheath diameter (ONSD) and intracranial pressure (ICP) in patients with traumatic brain injury (TBI), and the ability …
View article: PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers
PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers Open
Progesterone-induced rapid non-genomic signaling events have been confirmed through several membrane progesterone receptors (mPR). Some mPRs were reported to correlate with cancer progression and patient prognosis. In this study, we conduc…
View article: Risk Factors and Neurologic Outcomes in Patients with Traumatic Brain Injury and Coagulopathy Within 72 h After Surgery
Risk Factors and Neurologic Outcomes in Patients with Traumatic Brain Injury and Coagulopathy Within 72 h After Surgery Open
Taking practical and reasonable measures to manage these risk factors may protect patients with TBI from postoperative coagulopathy.
View article: Management and Molecular Diagnosis of Persistent Müllerian Duct Syndrome in Chinese Patients
Management and Molecular Diagnosis of Persistent Müllerian Duct Syndrome in Chinese Patients Open
Background: To report the management and molecular findings of patients with persistent Müllerian duct syndrome (PMDS). Materials and Methods: The hospital records of PMDS patients seen in our center between 2012 and 2020 were retrospectiv…
View article: Risk Factors and Neurologic Outcomes in Patients With Traumatic Brain Injury and Coagulopathy Within 72 Hours Post-operatively
Risk Factors and Neurologic Outcomes in Patients With Traumatic Brain Injury and Coagulopathy Within 72 Hours Post-operatively Open
Background There are few studies on the development and effect of coagulopathy in patients with a traumatic brain injury (TBI) during the early post-operative period. We determined the risk factors and neurologic outcomes of in patients wi…
View article: Identification of risk factors associated with numerous reoperations following primary hypospadias repair
Identification of risk factors associated with numerous reoperations following primary hypospadias repair Open
Severe recurrent ventral curvature, urethral stricture, dehiscence and primary staged hypospadias repair were associated with numerous reoperations following primary hypospadias repair.
View article: Renal malignant tumor with the loss of INI1 expression and WT1 positive in a 3-year-old boy: a case report
Renal malignant tumor with the loss of INI1 expression and WT1 positive in a 3-year-old boy: a case report Open
Wilms' tumor is the most common primary renal malignancy in children (80%) and the less common tumors include renal cell carcinoma, rhabdoid tumor, clear cell sarcoma, cellular congenital mesoblastic nephroma and medullary carcinoma, all o…
View article: Noninvasive Evaluation of Intracranial Pressure by Transcranial Doppler Ultrasound in Patients With Traumatic Brain Injury
Noninvasive Evaluation of Intracranial Pressure by Transcranial Doppler Ultrasound in Patients With Traumatic Brain Injury Open
Background As a noninvasive monitoring measure, transcranial Doppler ultrasound (TCD) has been widely used to monitor the secondary brain injury in patients with traumatic brain injury (TBI). There are different physiological theories on t…
View article: [Fetal anteroposterior renal pelvic diameter for predicting antenatal hydronephrosis requiring postnatal surgery].
[Fetal anteroposterior renal pelvic diameter for predicting antenatal hydronephrosis requiring postnatal surgery]. Open
APD in pregnancy can be used to predict whether the fetus with hydronephrosis needs surgical treatment after birth, and the prediction value of APD in the middle pregnancy is better.
View article: Treatment efficacy of tolterodine versus belladonna mixture in children with idiopathic overactive bladder
Treatment efficacy of tolterodine versus belladonna mixture in children with idiopathic overactive bladder Open
Objectives Children with symptoms of urinary urgency, frequency and incontinence are common in the clinic. The aim of the present study was to compare the tolerability and efficacy of tolterodine, a bladder-selective muscarinic receptor an…
View article: Width proportion of the urethral plate to the glans can serve as an appraisal index of the urethral plate in hypospadias repair
Width proportion of the urethral plate to the glans can serve as an appraisal index of the urethral plate in hypospadias repair Open
Objectives To find a new appropriate evaluation for urethral plate quality in hypospadias repair, with particular interest in the width proportion of the urethral plate to the glans, serving as an appraisal index. Methods Data were prospec…
View article: Clinical features of multiple spontaneous intracerebral hemorrhages
Clinical features of multiple spontaneous intracerebral hemorrhages Open
Objective To analyze the clinical features of multiple spontaneous intracerebral hemorrhages (MICH). Methods Conservative therapy, puncture and drainage, hematoma removal and/or decompressive craniectomy were used in the treatment of …