Chenxi Zhou
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View article: Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia
Forty new genomes shed light on sexual reproduction and the origin of tetraploidy in Microsporidia Open
Microsporidia are single-celled, obligately intracellular parasites with growing public health, agricultural, and economic importance. Despite this, Microsporidia remain relatively enigmatic, with many aspects of their biology and evolutio…
View article: Integrated network pharmacology, molecular docking, and experiments in vivo and in vitro to explore the efficacy and potential mechanism of Chrysanthemum indicum L. extract against glioma
Integrated network pharmacology, molecular docking, and experiments in vivo and in vitro to explore the efficacy and potential mechanism of Chrysanthemum indicum L. extract against glioma Open
View article: Zebrafish Xenografts Reveal a Context-dependent Role of PFKFB4 in Melanoma Cell
Zebrafish Xenografts Reveal a Context-dependent Role of PFKFB4 in Melanoma Cell Open
Cutaneous melanoma is a highly metastatic cancer in which tumor cell plasticity drives transitions between proliferative and invasive states. The glycolytic regulator PFKFB4 has been implicated in cancer cell motility, but its role in mela…
View article: Pangenome-guided sequence assembly via binary optimisation
Pangenome-guided sequence assembly via binary optimisation Open
De novo genome assembly is challenging in highly repetitive regions; however, reference-guided assemblers often suffer from bias. We propose a framework for pangenome-guided sequence assembly, which can resolve short-read data in complex r…
View article: Oatk: a de novo assembly tool for complex plant organelle genomes
Oatk: a de novo assembly tool for complex plant organelle genomes Open
View article: Decoding the Spatial–Temporal Coupling Dynamics of Land Use Intensity and Balance in China’s Chengdu–Chongqing Economic Circle: A 1 km Grid-Based Analysis
Decoding the Spatial–Temporal Coupling Dynamics of Land Use Intensity and Balance in China’s Chengdu–Chongqing Economic Circle: A 1 km Grid-Based Analysis Open
Amid China’s national strategic prioritization of the Chengdu–Chongqing Economic Circle and accelerated territorial spatial planning, this study deciphered the synergistic evolution of Land Use Intensity (LUI) and Balance Degree of Land Us…
View article: Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing
Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing Open
Recombination is central to genetics and to evolution of sexually reproducing organisms. However, obtaining accurate estimates of recombination rates, and of how they vary along chromosomes, continues to be challenging. To advance our abil…
View article: Cyclical evolution of centromere architecture across 193 eukaryote species
Cyclical evolution of centromere architecture across 193 eukaryote species Open
Eukaryotic chromosomes rely on centromeres for attachment to spindle microtubules and segregation during cell division, yet exhibit a paradoxical diversity of architectures, including satellite arrays, transposon clusters, and holocentrici…
View article: Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver
Adaptation of Diqing Tibetan pigs to hypoxic and cold environments through extramedullary hematopoiesis and uncoupled thermogenesis in the liver Open
In summary, our study provides new scientific perspectives on the adaptation mechanisms of high-altitude animals to extreme environments.
View article: FastGA: Fast Genome Alignment
FastGA: Fast Genome Alignment Open
FastGA finds alignments between two genome sequences more than an order of magnitude faster than previous methods that have comparable sensitivity. Its speed is due to (a) a carefully engineered architecture involving only cache-coherent M…
View article: Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation
Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation Open
Chromosomal inversions can contribute to adaptive speciation by linking coadapted alleles. By querying 1375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large inversions segregating in the benthic subradiat…
View article: Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia
Forty New Genomes Shed Light on Sexual Reproduction and the Origin of Tetraploidy in Microsporidia Open
Microsporidia are single-celled, obligately intracellular parasites with growing public health, agricultural, and economic importance. Despite this, Microsporidia remain relatively enigmatic, with many aspects of their biology and evolutio…
View article: Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway
Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway Open
View article: Bispecific antibodies combined with chemotherapy in solid tumor treatment, the path forward?
Bispecific antibodies combined with chemotherapy in solid tumor treatment, the path forward? Open
Background Bispecific antibodies (bsAbs) introduced a novel strategy in anticancer therapy when chemotherapy alone could not meet life expectancy. Nonetheless, the efficacy of monotherapy was limited, and the safety profile of bsAbs combin…
View article: Initialization-Free Programmable Spin-Logic Gate in a Single Spin-Orbit Torque Device
Initialization-Free Programmable Spin-Logic Gate in a Single Spin-Orbit Torque Device Open
In-memory computing (IMC) based on spin-logic devices is regarded as an advantageous way to optimize the Von Neumann bottleneck. However, performing complete Boolean logic with spintronic devices typically requires an initialization operat…
View article: Association between the dietary inflammatory index, bowel habits, and systemic serum inflammatory markers: insights from NHANES (2005–2010)
Association between the dietary inflammatory index, bowel habits, and systemic serum inflammatory markers: insights from NHANES (2005–2010) Open
Objective To examine the relationship between the Dietary Inflammatory Index (DII), abnormal bowel habits, and systemic serum inflammatory markers. Methods Data from 9,880 participants in the National Health and Nutrition Examination Surve…
View article: A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisation
A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisation Open
Application of transcriptomics, proteomics and metabolomics technologies to clinical cohorts has uncovered a variety of signatures for predicting disease. Many of these signatures require the full ‘omics data for evaluation on unseen sampl…
View article: Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing
Hi-reComb: constructing recombination maps from bulk gamete Hi-C sequencing Open
Summary Recombination is central to genetics and to evolution of sexually reproducing organisms. However, obtaining accurate estimates of recombination rates, and of how they vary along chromosomes, continues to be challenging. To advance …
View article: Genetic Insights into Body Size Variation and High-Altitude Adaptation in Diqing Tibetan Pigs: A Comparative Genomic Analysis
Genetic Insights into Body Size Variation and High-Altitude Adaptation in Diqing Tibetan Pigs: A Comparative Genomic Analysis Open
View article: Discernible phenotypic alterations following linc-10 knockout in Caenorhabditis elegans
Discernible phenotypic alterations following linc-10 knockout in Caenorhabditis elegans Open
View article: FastGA: fast genome alignment
FastGA: fast genome alignment Open
Motivation FastGA finds alignments between two genome sequences more than an order of magnitude faster than previous methods that have comparable sensitivity. Its speed is due to (i) a fully cache-local architecture involving only MSD radi…
View article: Enhanced Self-Supervised Transmission Inspection with Improved Region Prior and Scale Variation
Enhanced Self-Supervised Transmission Inspection with Improved Region Prior and Scale Variation Open
As an important means to ensure the safety of power transmission, the inspection of overhead transmission lines requires high accuracy for detecting small objects on the transmission lines and relies heavily on the construction of large-sc…
View article: Oatk: a de novo assembly tool for complex plant organelle genomes
Oatk: a de novo assembly tool for complex plant organelle genomes Open
Plant organelle genomes, particularly the large mitochondrial genomes with intricate repetitive structures, present significant challenges for assembly. The advent of long-read sequencing technologies provides a transformative opportunity …
View article: Risk analysis of postoperative nausea and vomiting in patients after gynecologic laparoscopic surgery
Risk analysis of postoperative nausea and vomiting in patients after gynecologic laparoscopic surgery Open
A nomogram model was developed to predict the incidence of PONV in patients after gynecologic laparoscopic surgery. This model was found to be reliable and of high clinical value.
View article: Translation and psychometric validation of the Patient Participation Culture Tool for healthcare workers in Chinese nursing context
Translation and psychometric validation of the Patient Participation Culture Tool for healthcare workers in Chinese nursing context Open
View article: Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid adaptive radiation
Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid adaptive radiation Open
Chromosomal inversions contribute to adaptive speciation by linking co-adapted alleles. Querying 1,375 genomes of the species-rich Malawi cichlid fish radiation, we discovered five large inversions segregating in the benthic subradiation t…
View article: Insights into non-crossover recombination from long-read sperm sequencing
Insights into non-crossover recombination from long-read sperm sequencing Open
Meiotic recombination is a fundamental process that generates genetic diversity by creating new combinations of existing alleles. Although human crossovers have been studied at the pedigree, population and single-cell level, the more frequ…
View article: A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisation
A flexible framework for minimal biomarker signature discovery from clinical omics studies without library size normalisation Open
Application of transcriptomics, proteomics and metabolomics technologies to clinical cohorts has uncovered a variety of signatures for predicting disease. Many of these signatures require the full ‘omics data for evaluation on unseen sampl…
View article: Specular Polynomials
Specular Polynomials Open
Finding valid light paths that involve specular vertices in Monte Carlo rendering requires solving many non-linear, transcendental equations in high-dimensional space. Existing approaches heavily rely on Newton iterations in path space, wh…
View article: Room temperature photosensitive ferromagnetic semiconductor using MoS2
Room temperature photosensitive ferromagnetic semiconductor using MoS2 Open
Two-dimensional semiconductors, including transition metal dichalcogenides (TMDs), are of interest in electronics and photonics but remain nonmagnetic in their intrinsic form. Atomic modulation using physical and chemical ways is an effect…