Chenxia Wu
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View article: Advances in Molecular Mechanisms and Precision Interventions of Cardiovascular Injuries Related to Glucose and Lipid Metabolism Disorders
Advances in Molecular Mechanisms and Precision Interventions of Cardiovascular Injuries Related to Glucose and Lipid Metabolism Disorders Open
This article reviews the latest research progress (2018–2025) on the molecular mechanisms linking glucose and lipid metabolism disorders (GLMDs) to cardiovascular injury, specifically atherosclerotic cardiovascular disease (ASCVD), diabeti…
View article: The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice
The Tanyu Tongzhi Formula enhances IL-10 expression and macrophage efferocytosis to alleviate atherosclerosis in mice Open
IL-10-mediated efferocytosis potentiation is the critical pathway through which TTF stabilizes atherosclerotic plaques. The NF-κB/IL-10/efferocytosis axis provides a novel pharmacological target for macrophage-directed anti-atherosclerotic…
View article: The Critical Role of Faecalibacterium prausnitzii in Cardiovascular Diseases
The Critical Role of Faecalibacterium prausnitzii in Cardiovascular Diseases Open
Due to the continued aging of the global population, cardiovascular diseases (CVDs) remain the main cause of death worldwide, with millions of fatalities from diseases, including stroke and coronary artery disease, reported annually. Thus,…
View article: Silent cerebral lesions after catheter ablation for atrial fibrillation using cryoballoon, hotballoon, laserballoon and radiofrequency catheters: a Bayesian network meta-analysis
Silent cerebral lesions after catheter ablation for atrial fibrillation using cryoballoon, hotballoon, laserballoon and radiofrequency catheters: a Bayesian network meta-analysis Open
Background Catheter ablation (CA) is an effective therapeutic option for patients with symptomatic atrial fibrillation (AF). Previous studies have reported silent cerebral lesions (SCLs) detected by magnetic resonance imaging (MRI) after d…
View article: A novel approach to the prevention and management of chemotherapy-induced cardiotoxicity: PANoptosis
A novel approach to the prevention and management of chemotherapy-induced cardiotoxicity: PANoptosis Open
As a fundamental component of antitumor therapy, chemotherapy-induced cardiotoxicity (CIC) has emerged as a leading cause of long-term mortality in patients with malignant tumors. Unfortunately, there are currently no effective therapeutic…
View article: Identification of Macrophage-related Gene Signature Associated with Unstable Atherosclerotic Plaques through Integrative Multi- omics Analysis
Identification of Macrophage-related Gene Signature Associated with Unstable Atherosclerotic Plaques through Integrative Multi- omics Analysis Open
Background: Macrophages play a crucial role in the occurrence and development of atherosclerosis. The purpose of this study is to identify critical candidate genes associated with unstable atherosclerotic plaques in macrophages Methods : T…
View article: Bayesian network meta-analysis comparing hot balloon, laser balloon and cryoballoon ablation as initial therapies for atrial fibrillation
Bayesian network meta-analysis comparing hot balloon, laser balloon and cryoballoon ablation as initial therapies for atrial fibrillation Open
Background Balloon-based catheter ablation (CA) technologies, including hot balloon ablation (HBA), laser balloon ablation (LBA) and cryoballoon ablation (CBA) have been introduced in recent years as alternatives to conventional radiofrequ…
View article: Predictive value of extubation failure by decrease in central venous oxygen saturation: A systematic review and meta-analysis
Predictive value of extubation failure by decrease in central venous oxygen saturation: A systematic review and meta-analysis Open
The ΔScvO2 performed well in predicting extubation failure in adult mechanical ventilation patients. Further studies with a larger data set and well-designed models are required to confirm the diagnostic accuracy and utility of ScvO2 in pr…
View article: Predictive value of extubation failure diagnosed by decrease in central venous oxygen saturation: a systematic review and meta-analysis
Predictive value of extubation failure diagnosed by decrease in central venous oxygen saturation: a systematic review and meta-analysis Open
Background: The predictive power of extubation failure diagnosed by decrease in central venous oxygen saturation(ΔScvO2) varies by studies. Here we summarized the diagnostic value of extubation failure tested by ΔScvO2. Methods: A comprehe…
View article: Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis
Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis Open
View article: Tanyu Tongzhi Formula Delays Atherosclerotic Plaque Progression by Promoting Alternative Macrophage Activation via PPARγ and AKT/ERK Signal Pathway in ApoE Knock-Out Mice
Tanyu Tongzhi Formula Delays Atherosclerotic Plaque Progression by Promoting Alternative Macrophage Activation via PPARγ and AKT/ERK Signal Pathway in ApoE Knock-Out Mice Open
We previously demonstrated that the Tanyu Tongzhi Formula (TTF) significantly alleviated the clinical symptoms of patients with coronary heart disease and lowered serum lipid and inflammatory factor levels in patients with coronary heart d…
View article: Value of Variation of End-Tidal Carbon Dioxide for Predicting Fluid Responsiveness During the Passive Leg Raising Test in Patients with Mechanical Ventilation: A Systematic Review and Meta-Analysis
Value of Variation of End-Tidal Carbon Dioxide for Predicting Fluid Responsiveness During the Passive Leg Raising Test in Patients with Mechanical Ventilation: A Systematic Review and Meta-Analysis Open
Background : The variation of end-tidal carbon dioxide(ΔEtCO2) has have been extensively studied with respect to its value in predicting fluid responsiveness, but the results are conflicting. This meta-analysis aimed to explore the value o…
View article: Second-generation cryoballoon versus contact force radiofrequency ablation for atrial fibrillation: an updated meta-analysis of evidence from randomized controlled trials
Second-generation cryoballoon versus contact force radiofrequency ablation for atrial fibrillation: an updated meta-analysis of evidence from randomized controlled trials Open
View article: Nursing Experience of Octreotide in Treating Hypoglycemia in Acute Pancreatitis
Nursing Experience of Octreotide in Treating Hypoglycemia in Acute Pancreatitis Open
Objective: This article studies the therapeutic effect and nursing experience of octreotide in treating hypoglycemia in acute pancreatitis. Method: Sixty patients with acute pancreatitis treated in our hospital from January 2019 to Februar…
View article: Analysis on Nursing Effect of Octreotide on Acute Pancreatitis
Analysis on Nursing Effect of Octreotide on Acute Pancreatitis Open
To explore the clinical value of octreotide therapy and nursing intervention in patients with acute pancreatitis. 120 patients with acute pancreatitis admitted to the Department of Digestive Medicine from June 2018 to August 2019 were sele…
View article: The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis
The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis Open
Early initiation of vasopressin in patients within 6 h of septic shock onset was not associated with decreased short-term mortality, new onset arrhythmias, shorter ICU length of stay and length of hospitalization, but can reduce the use of…
View article: Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis
Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis Open
Background: In recent years, galectin-3, an inflammatory marker, has been demonstrated to be closely related to cardiac fibrosis and heart failure. The purpose of this systematic review and meta-analysis is to define galectin-3 in predicti…
View article: Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome
Bioinformatics Analysis Reveals Diagnostic Markers and Vital Pathways Involved in Acute Coronary Syndrome Open
Background. Acute coronary syndrome (ACS) has a high incidence and mortality rate. Early detection and intervention would provide clinical benefits. This study aimed to reveal hub genes, transcription factors (TFs), and microRNAs (miRNAs) …
View article: The Effect of Early Vasopressin Use on Patients With Septic Shock: A Systematic Review and Meta-analysis
The Effect of Early Vasopressin Use on Patients With Septic Shock: A Systematic Review and Meta-analysis Open
Background: The effect of early vasopressin initiation on clinical outcomes in patients with septic shock is uncertain. A systematic review and meta-analysis was performed to evaluate the impact of early start of vasopressin support within…