Chengwen Zhou
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View article: Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model
Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model Open
In patients with refractory epilepsy, states of sleep and wakefulness affect the expression of seizures. However, the mechanism by which subcortical sleep circuitry affects seizures is unknown. Here, using Gabrg2Q390X knock-in (KI) genetic…
View article: Preliminary study on the correlation between thyroid magnetic resonance parameters and radiation dose after radiotherapy for nasopharyngeal carcinoma
Preliminary study on the correlation between thyroid magnetic resonance parameters and radiation dose after radiotherapy for nasopharyngeal carcinoma Open
Background Hypothyroidism is a common sequela after radiotherapy for nasopharyngeal carcinoma (NPC). Magnetic resonance imaging (MRI) has gained prominence in thyroid imaging, leveraging its non-ionizing radiation, high spatial resolution,…
View article: An Open-Source Mouse Chronic EEG Array System with High-Density MXene-Based Skull Surface Electrodes
An Open-Source Mouse Chronic EEG Array System with High-Density MXene-Based Skull Surface Electrodes Open
Electroencephalography (EEG) is an indispensable tool in epilepsy, sleep, and behavioral research. In rodents, EEG recordings are typically performed with metal electrodes that traverse the skull into the epidural space. In addition to req…
View article: Preoptic area controls sleep-related seizure onset in a genetic epilepsy mouse model
Preoptic area controls sleep-related seizure onset in a genetic epilepsy mouse model Open
In genetic and refractory epileptic patients, seizure activity exhibits sleep-related modulation/regulation and sleep and seizure are intermingled. In this study, by using one het Gabrg2 Q390X KI mice as a genetic epilepsy model and optoge…
View article: E-243 Measures of quantified intracranial aneurysm wall enhancement on high resolution MR vessel wall imaging and their associations with the PHASES score
E-243 Measures of quantified intracranial aneurysm wall enhancement on high resolution MR vessel wall imaging and their associations with the PHASES score Open
Introduction Globally, the incidence of intracranial aneurysms is estimated to range between 3 and 5%. Despite the low rupture rate of approximately 3-50/100000, mortality and morbidity among patients with ruptured IA remain as high as 50%…
View article: An Open-Source Rodent Chronic EEG Array System with High Density MXene-Based Skull Surface Electrodes
An Open-Source Rodent Chronic EEG Array System with High Density MXene-Based Skull Surface Electrodes Open
Electroencephalography (EEG) is an indispensable tool in epilepsy, sleep, and behavioral research. In rodents, EEG recordings are typically performed with metal electrodes that traverse the skull into the epidural space. In addition to req…
View article: Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome
Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome Open
Sleep is the preferential period when epileptic spike–wave discharges appear in human epileptic patients, including genetic epileptic seizures such as Dravet syndrome with multiple mutations including SCN1A mutation and GABAA receptor γ2 s…
View article: Heterozygous <scp>GABA<sub>A</sub></scp> receptor β3 subunit <scp>N110D</scp> knock‐in mice have epileptic spasms
Heterozygous <span>GABA<sub>A</sub></span> receptor β3 subunit <span>N110D</span> knock‐in mice have epileptic spasms Open
Objective Infantile spasms is an epileptic encephalopathy of childhood, and its pathophysiology is largely unknown. We generated a heterozygous knock‐in mouse with the human infantile spasms‐associated de novo mutation GABRB3 (c.A328G, p.N…
View article: Artificial sleep-like up/down-states induce synaptic plasticity in cortical neurons from mouse brain slices
Artificial sleep-like up/down-states induce synaptic plasticity in cortical neurons from mouse brain slices Open
During non-rapid eye movement (NREM) sleep, cortical neuron activity alternates between a depolarized (firing, up-state) and a hyperpolarized state (down-state) coinciding with delta electroencephalogram (EEG) slow-wave oscillation (SWO, 0…
View article: Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons
Discovery of a small-molecule inhibitor of the TRIP8b–HCN interaction with efficacy in neurons Open
Major depressive disorder is a critical public health problem with a lifetime prevalence of nearly 17% in the United States. One potential therapeutic target is the interaction between hyperpolarization-activated cyclic nucleotide-gated (H…
View article: Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome
Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndrome Open
Sleep is the brain state when cortical activity decreases and memory consolidates. However, in human epileptic patients, including genetic epileptic seizures such as Dravet syndrome, sleep is the preferential period when epileptic spike-wa…
View article: Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior
Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior Open
cAMP-mediated effect on HCN channel surface trafficking and mouse behavior depends on activation time scale.
View article: Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Dentate Gyrus
Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Dentate Gyrus Open
View article: The K328M substitution in the human GABAA receptor gamma2 subunit causes GEFS+ and premature sudden death in knock-in mice
The K328M substitution in the human GABAA receptor gamma2 subunit causes GEFS+ and premature sudden death in knock-in mice Open
View article: OUP accepted manuscript
OUP accepted manuscript Open
Fragile X syndrome (FXS) is the leading monogenic form of intellectual disability and autism, with patients exhibiting numerous auditory-related phenotypes during their developmental period, including communication, language development, a…
View article: Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus
Modeling intrahippocampal effects of anterior hippocampal hyperactivity relevant to schizophrenia using chemogenetic excitation of long axis-projecting mossy cells in the mouse dentate gyrus Open
Background The anterior hippocampus of individuals with early psychosis or schizophrenia is hyperactive, as is the ventral hippocampus in rodent models for schizophrenia risk. Hyperactive ventral hippocampal projections to extrahippocampal…
View article: Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model
Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model Open
Epileptic activity in genetic generalized epilepsy (GGE) patients preferentially appears during sleep and its mechanism remains unknown. Here, we found that sleep-like slow-wave oscillations (0.5 Hz SWOs) potentiated excitatory and inhibit…
View article: Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model
Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy model Open
Idiopathic generalized epilepsy(IGE) patients have genetic causes and their seizure onset mechanisms particularly during sleep remain elusive. Here we proposed that sleep-like slow-wave oscillations(0.5 Hz SWOs) potentiated excitatory or i…
View article: Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1
Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1 Open
Mutations in DEP domain containing 5 (DEPDC5) are increasingly appreciated as one of the most common causes of inherited focal epilepsy. Epilepsies due to DEPDC5 mutations are often associated with brain malformations, tend to be drug-resi…
View article: GABAA receptor β3 subunit mutation D120N causes Lennox–Gastaut syndrome in knock-in mice
GABAA receptor β3 subunit mutation D120N causes Lennox–Gastaut syndrome in knock-in mice Open
The Lennox–Gastaut syndrome is a devastating early-onset epileptic encephalopathy, associated with severe behavioural abnormalities. Its pathophysiology, however, is largely unknown. A de novo mutation (c.G358A, p.D120N) in the human GABA …
View article: Cortical activation in generalized seizures
Cortical activation in generalized seizures Open
Objective Patients with generalized epilepsy exhibit different epileptiform events including asymptomatic interictal spikes ( IS ), absence seizures with spike‐wave discharges ( SWD s), and myoclonic seizures ( MS ). Our objective was to d…
View article: Overexpressing wild‐type γ2 subunits rescued the seizure phenotype in <i>Gabrg2</i><sup><i>+/Q390X</i></sup> Dravet syndrome mice
Overexpressing wild‐type γ2 subunits rescued the seizure phenotype in <i>Gabrg2</i><sup><i>+/Q390X</i></sup> Dravet syndrome mice Open
Summary Objective The mutant γ‐aminobutyric acid type A ( GABA A ) receptor γ2(Q390X) subunit (Q351X in the mature peptide) has been associated with the epileptic encephalopathy, Dravet syndrome, and the epilepsy syndrome genetic epilepsy …
View article: Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity
Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity Open
View article: Neonatal seizures alter NMDA glutamate receptor GluN2A and 3A subunit expression and function in hippocampal CA1 neurons
Neonatal seizures alter NMDA glutamate receptor GluN2A and 3A subunit expression and function in hippocampal CA1 neurons Open
Neonatal seizures are commonly caused by hypoxic and/or ischemic injury during birth and can lead to long-term epilepsy and cognitive deficits. In a rodent hypoxic seizure (HS) model, we have previously demonstrated a critical role for sei…
View article: The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy
The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy Open
View article: The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration
The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration Open