Yan Cheng
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View article: MiRNA expression analysis from circulating exosomes in Barrett’s esophagus patients with visceral obesity
MiRNA expression analysis from circulating exosomes in Barrett’s esophagus patients with visceral obesity Open
Visceral obesity is a recognized risk factor for Barrett’s esophagus (BE). Circulating exosomal mirnas have been identified as potential biomarkers of BE. The aim of this study was to elucidate the characteristics of plasma exosomal miRNA …
View article: Passive Immunity Establishment Through Colostral IgG Absorption in Neonatal Ruminants: Foundation for Efficient Ruminant Production
Passive Immunity Establishment Through Colostral IgG Absorption in Neonatal Ruminants: Foundation for Efficient Ruminant Production Open
Passive immunity, the acquisition of specific immune protection through external antibodies or immune components, is critically important for neonatal survival. In ruminants, however, neonatal hypogammaglobulinemia, a consequence of their …
View article: Influences of structural helicity of aortic dissection on endovascular repair
Influences of structural helicity of aortic dissection on endovascular repair Open
View article: Single-Cell RNA Sequencing Outperforms Single-Nucleus RNA Sequencing in Analyzing Pancreatic Cell Diversity and Gene Expression in Goats
Single-Cell RNA Sequencing Outperforms Single-Nucleus RNA Sequencing in Analyzing Pancreatic Cell Diversity and Gene Expression in Goats Open
The objective of this study was to determine whether single-cell RNA sequencing (scRNA-seq) or single-nucleus RNA sequencing (snRNA-seq) was more effective for studying the goat pancreas. Pancreas tissues from three healthy 10-day-old fema…
View article: Multi-omics analysis provides new insights into the molecular mechanisms underlying colostral immunoglobulin G absorption in the gut of neonatal goat kids
Multi-omics analysis provides new insights into the molecular mechanisms underlying colostral immunoglobulin G absorption in the gut of neonatal goat kids Open
View article: Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants
Low expression of CCKBR in the acinar cells is associated with insufficient starch hydrolysis in ruminants Open
View article: Laser Oscillation Diameter Variation Effect on Laser Wire Additive Manufacturing Deposition Morphology
Laser Oscillation Diameter Variation Effect on Laser Wire Additive Manufacturing Deposition Morphology Open
A high-speed camera was employed to capture the melting process and investigate the impact of laser beam oscillation diameter on weld pool fluctuation and deposition morphology during laser wire additive manufacturing (LWAM) of 316L wire. …
View article: In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery
In vivo genome editing of human hematopoietic stem cells for treatment of blood disorders by mRNA delivery Open
SUMMARY Ex vivo autologous hematopoietic stem cells (HSCs) gene therapy provides promising new treatments for hematological disorders. However, current methods involve complex processes and chemotherapeutic conditioning, leading to limited…
View article: Ruminal microbial metagenomes and host transcriptomes shed light on individual variability in the growth rate of lambs before weaning: the regulated mechanism and potential long-term effect on the host
Ruminal microbial metagenomes and host transcriptomes shed light on individual variability in the growth rate of lambs before weaning: the regulated mechanism and potential long-term effect on the host Open
Weaning weight is a reflection of management during the breastfeeding phase and will influence animal performance in subsequent phases, considered important indicators within production systems. The aims of this study were as follows: (i) …
View article: Data from Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase
Data from Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase Open
Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nas…
View article: Data from Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase
Data from Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase Open
Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nas…
View article: Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs
Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs Open
View article: Lipid metabolism and m6A RNA methylation are altered in lambs supplemented rumen-protected methionine and lysine in a low-protein diet
Lipid metabolism and m6A RNA methylation are altered in lambs supplemented rumen-protected methionine and lysine in a low-protein diet Open
View article: Inosine monophosphate dehydrogenase type1 sustains tumor growth in hepatocellular carcinoma
Inosine monophosphate dehydrogenase type1 sustains tumor growth in hepatocellular carcinoma Open
Background Inosine monophosphate dehydrogenase (IMPDH) is the key enzyme in the biosynthesis of purine nucleotides. IMPDH1 and IMPDH2 are the two isoforms of IMPDH and they share 84% amino acid similarity and virtually indistinguishable ca…
View article: Effects of substituting soybean meal with corn on immune function and gene expression of gut TLR4 pathway of growing goats
Effects of substituting soybean meal with corn on immune function and gene expression of gut TLR4 pathway of growing goats Open
Background Protein malnutrition remains a severe problem in ruminant production and can increase susceptibility to infection, especially during the growth stage. This study aimed to explore substituting soybean meal with corn on activation…
View article: Supplementing Mannan Oligosaccharide Reduces the Passive Transfer of Immunoglobulin G and Improves Antioxidative Capacity, Immunity, and Intestinal Microbiota in Neonatal Goats
Supplementing Mannan Oligosaccharide Reduces the Passive Transfer of Immunoglobulin G and Improves Antioxidative Capacity, Immunity, and Intestinal Microbiota in Neonatal Goats Open
Successful establishment of passive immunity (PIT) and regulation of intestinal microbiota are crucial for ruminants to maintain body health and reduce the risk of disease during the neonatal period. Thus, the objective of this study was t…
View article: Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Diarrhoea Kids
Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Diarrhoea Kids Open
Diarrhea and disorders in young goats are serious threats to the animals' health, influencing the profitability of the goat industry. There is a need to better understand the potential biomarkers that can reflect the mortality and morbidit…
View article: Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Goats Suffering from a Cold
Changes of Intestinal Oxidative Stress, Inflammation, and Gene Expression in Neonatal Goats Suffering from a Cold Open
Background Disease and disorders in young goats are serious threats to the animals’ health, and they influence the profitability of the goat industry. There is a need to better understand the potential biomarkers that can reflect the morta…
View article: Circulating exosomal miRNAs as potential biomarkers for Barrett's esophagus and esophageal adenocarcinoma
Circulating exosomal miRNAs as potential biomarkers for Barrett's esophagus and esophageal adenocarcinoma Open
Exosomes, a class of extracellular vesicles, are small membrane-bound vesicles derived from almost all cell types that can play important roles in intercellular communication. Exosomes contain proteins, lipids, and nucleic acids that are o…
View article: Supplementation of Lactobacillus plantarum or Macleaya cordata Extract Alleviates Oxidative Damage Induced by Weaning in the Lower Gut of Young Goats
Supplementation of Lactobacillus plantarum or Macleaya cordata Extract Alleviates Oxidative Damage Induced by Weaning in the Lower Gut of Young Goats Open
Weaning usually leads to stress in livestock, which has a negative impact on their growth and development. Research on oxidative stress and inflammation induced by weaning has not been reported in goats. Here, we focused on oxidative stres…
View article: Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model
Bone Marrow Endothelial Progenitor Cells Are the Cellular Mediators of Pulmonary Hypertension in the Murine Monocrotaline Injury Model Open
The role of bone marrow (BM) cells in modulating pulmonary hypertensive responses is not well understood. Determine if BM-derived endothelial progenitor cells (EPCs) induce pulmonary hypertension (PH) and if this is attenuated by mesenchym…
View article: Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway
Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway Open
View article: Association between the expression of T-cadherin and vascular endothelial growth factor and the prognosis of patients with gastric cancer
Association between the expression of T-cadherin and vascular endothelial growth factor and the prognosis of patients with gastric cancer Open
T-cadherin has been identified as a tumor-suppressor gene in several types of cancer. The present study aimed to investigate the association of the expression of T-cadherin with angiogenesis, and to evaluate its prognostic value for patien…
View article: BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis
BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis Open
BioXpress is a gene expression and cancer association database in which the expression levels are mapped to genes using RNA-seq data obtained from The Cancer Genome Atlas, International Cancer Genome Consortium, Expression Atlas and public…