Chenxuan Wang
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View article: Inverse-Time Overcurrent Protection Scheme for Smart Grids Based on Composite Parameter Protection Factors
Inverse-Time Overcurrent Protection Scheme for Smart Grids Based on Composite Parameter Protection Factors Open
When internal faults occur in a microgrid, the switching between grid-connected and islanded modes can lead to extended tripping times for traditional inverse-time overcurrent (ITOC) protection and failure in coordination between protectio…
View article: Submolecular Resolution of β-Sheet Plasticity: Decoding Mutations and PTMs in Protein Aggregation Disorders
Submolecular Resolution of β-Sheet Plasticity: Decoding Mutations and PTMs in Protein Aggregation Disorders Open
The functional diversity of proteins often arises from the remodeling of conformational ensembles, particularly through mutations and post-translational modifications (PTMs). However, experimentally characterizing such ensembles remains ch…
View article: Effects of Celastrol-Enriched Peanuts on Metabolic Health and the Development of Atherosclerosis
Effects of Celastrol-Enriched Peanuts on Metabolic Health and the Development of Atherosclerosis Open
Background: Celastrol, a pentacyclic triterpenoid active component isolated from the root bark of the traditional medicinal plant Tripterygium wilfordii, displays significant anti-inflammatory, antioxidant, and immunomodulatory properties.…
View article: Cardiac <i>Slc25a49</i>‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis
Cardiac <i>Slc25a49</i>‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis Open
Doxorubicin (Dox), a potent antitumor drug, is linked to cardiac toxicity. Few mechanism‐based therapies against cardiotoxicity are available. Dysfunction in mitochondrial energy metabolism contributes to Dox‐induced cardiomyopathy. It is …
View article: TP53-centric ctDNA complements PET/CT for non-invasive assessment of pathological complete response and survival after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma: a prospective cohort study
TP53-centric ctDNA complements PET/CT for non-invasive assessment of pathological complete response and survival after neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma: a prospective cohort study Open
Background: Accurate assessment of pathologic complete response (pCR) after neoadjuvant immunochemotherapy (NICT) is crucial to implement active surveillance or tailor therapeutic strategies for esophageal squamous cell carcinoma (ESCC), w…
View article: SSVQ: Unleashing the Potential of Vector Quantization with Sign-Splitting
SSVQ: Unleashing the Potential of Vector Quantization with Sign-Splitting Open
Vector Quantization (VQ) has emerged as a prominent weight compression technique, showcasing substantially lower quantization errors than uniform quantization across diverse models, particularly in extreme compression scenarios. However, i…
View article: Correction: Defects-Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption
Correction: Defects-Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption Open
View article: Molecular characterization and biomarker identification in paediatric B‐cell acute lymphoblastic leukaemia
Molecular characterization and biomarker identification in paediatric B‐cell acute lymphoblastic leukaemia Open
B‐cell acute lymphoblastic leukaemia (B‐ALL) is the most prevalent hematologic malignancy in children and a leading cause of mortality. Managing B‐ALL remains challenging due to its heterogeneity and relapse risk. This study aimed to delin…
View article: Defects-Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption
Defects-Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption Open
Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies, as well as veiled dielectric-responsive character, are instrumental in electromagnetic dissipation. Conventional methods, however, constrain th…
View article: Technological advances and challenges in constructing complex gut organoid systems
Technological advances and challenges in constructing complex gut organoid systems Open
Recent advancements in organoid technology have heralded a transformative era in biomedical research, characterized by the emergence of gut organoids that replicate the structural and functional complexity of the human intestines. These st…
View article: Stable peptide-assembled nanozyme mimicking dual antifungal actions
Stable peptide-assembled nanozyme mimicking dual antifungal actions Open
View article: System Expansion Planning for Coordinated Source-network-load-stroage with Multiscale Uncertainties: A Case Study in China
System Expansion Planning for Coordinated Source-network-load-stroage with Multiscale Uncertainties: A Case Study in China Open
Development of the power system towards high renewable penetrated system requires various flexibility resources to grow economically and reliably. However, the multiscale uncertainties brought by the demand and renewable energy sources is …
View article: TP53-centric ctDNA complements PET/CT for Noninvasive Assessment of Pathological Complete Response and Survival after Neoadjuvant Immunochemotherapy in Esophageal Squamous Cell Carcinoma
TP53-centric ctDNA complements PET/CT for Noninvasive Assessment of Pathological Complete Response and Survival after Neoadjuvant Immunochemotherapy in Esophageal Squamous Cell Carcinoma Open
View article: Single-molecule visualization determines conformational substate ensembles in β-sheet–rich peptide fibrils
Single-molecule visualization determines conformational substate ensembles in β-sheet–rich peptide fibrils Open
An understanding of protein conformational ensembles is essential for revealing the underlying mechanisms of interpeptide recognition and association. However, experimentally resolving multiple simultaneously existing conformational substa…
View article: Experimental Insights into Conformational Ensembles of Assembled β-Sheet Peptides
Experimental Insights into Conformational Ensembles of Assembled β-Sheet Peptides Open
Deciphering the conformations and interactions of peptides in their assemblies offers a basis for guiding the rational design of peptide-assembled materials. Here we report the use of scanning tunneling microscopy (STM), a single-molecule …
View article: Editorial: The hierarchical organization of supramolecular systems: From fundamentals to biomedical applications, Volume II
Editorial: The hierarchical organization of supramolecular systems: From fundamentals to biomedical applications, Volume II Open
Self-assembly is a new frontier of chemistry. By constraining the covalent and noncovalent interactions 19 of molecular building blocks, self-assembly organizes molecules to form ordered structures on 20 different length scales. Highly spe…
View article: High-security image encryption by multiplexing phase encoding in domains of dual optical transforms
High-security image encryption by multiplexing phase encoding in domains of dual optical transforms Open
A novel optical image encryption is proposed based on multiplexing of the random phase encoding with shift and rotation operations in domains of two transforms, extended fractional Fourier transform (eFrFT) and Fresnel transform. The origi…
View article: High-security image encryption by multiplexing phase encoding in domains of dual optical transforms
High-security image encryption by multiplexing phase encoding in domains of dual optical transforms Open
A novel optical image encryption is proposed based on multiplexing of the random phase encoding after shift and rotation operations in domains of extended fractional Fourier transform (eFrFT) and Fresnel transform. The original image is su…
View article: Conservation and Identity Selection of Cationic Residues Flanking the Hydrophobic Regions in Intermediate Filament Superfamily
Conservation and Identity Selection of Cationic Residues Flanking the Hydrophobic Regions in Intermediate Filament Superfamily Open
The interplay between the hydrophobic interactions generated by the nonpolar region and the proximal functional groups within nanometers of the nonpolar region offers a promising strategy to manipulate the intermolecular hydrophobic attrac…
View article: Editorial: The Hierarchical Organization of Supramolecular Systems: From Fundamentals to Biomedical Applications
Editorial: The Hierarchical Organization of Supramolecular Systems: From Fundamentals to Biomedical Applications Open
EDITORIAL article Front. Bioeng. Biotechnol., 30 August 2021 | https://doi.org/10.3389/fbioe.2021.754980
View article: Opposite Regulatory Effects of Immobilized Cations on the Folding Vs. Assembly of Melittin
Opposite Regulatory Effects of Immobilized Cations on the Folding Vs. Assembly of Melittin Open
Ions are crucial in modulating the protein structure. For the free ions in bulk solution, ammonium is kosmotropic (structure forming) and guanidinium is chaotropic (structure breaking) to the protein structure within the Hofmeister series.…
View article: Trends in the biological functions and medical applications of extracellular vesicles and analogues
Trends in the biological functions and medical applications of extracellular vesicles and analogues Open
View article: The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis
The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis Open
Substantial controversies exist in the exploration of the molecular mechanism of heart failure (HF) and pose challenges to the diagnosis of HF and the discovery of specific drugs for the treatment. Recently, cardiac transthyretin (TTR) amy…
View article: A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly
A minireview on the perturbation effects of polar groups to direct nanoscale hydrophobic interaction and amphiphilic peptide assembly Open
Hydrophobic interaction provides the essential driving force for creating diverse native and artificial supramolecular architectures.
View article: Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures
Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures Open
Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific intere…
View article: Plant-Derived Nanovesicles: A Novel Form of Nanomedicine
Plant-Derived Nanovesicles: A Novel Form of Nanomedicine Open
The nanovesicles extracted from the plant and herbal decoctions are identified as a new class of nanomedicine. They are involved in interspecies chemical communication across the plant and animal kingdoms and display a therapeutic potentia…
View article: Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T
Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T Open
Single-molecule imaging reveals the oligomerization state specificity of drug on its protein receptor.
View article: Tumor Microenvironment–Responsive Peptide-Based Supramolecular Drug Delivery System
Tumor Microenvironment–Responsive Peptide-Based Supramolecular Drug Delivery System Open
Physical and biochemical differences between tumor tissues and normal tissues provide promising triggering factors that can be utilized to engineer stimuli-responsive drug delivery platforms for cancer treatment. Rationally designed peptid…
View article: Erratum to: Herbal decoctosome is a novel form of medicine
Erratum to: Herbal decoctosome is a novel form of medicine Open
View article: Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin α3 Toxicity
Use of a Stereochemical Strategy To Probe the Mechanism of Phenol-Soluble Modulin α3 Toxicity Open
Phenol-soluble modulin α3 (PSMα3) is a cytotoxic peptide secreted by virulent strains of Staphylococcus aureus. We used a stereochemical strategy to examine the mechanism of PSMα3-mediated toxicity. One hypothesis is that PSMα3 toxicity re…