Chris Yuan
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View article: Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach
Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach Open
Understanding how distinct neuronal subtypes contribute to Alzheimer’s disease (AD) pathology remains a major challenge. Patient-derived induced pluripotent stem cell (iPSC) studies have shown neuronal subtype-specific molecular and pathol…
View article: From Correlation to Causation: Cell-Type-Specific Gene Regulatory Networks in Alzheimer’s Disease
From Correlation to Causation: Cell-Type-Specific Gene Regulatory Networks in Alzheimer’s Disease Open
INTRODUCTION Alzheimer’s disease (AD) involves complex regulatory disruptions across multiple brain cell types, yet a comprehensive understanding of the intracellular causal mechanisms remains unclear. METHODS We presented an integrative a…
View article: Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of <i>Scn2a</i> -deficient mice
Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of <i>Scn2a</i> -deficient mice Open
Truncating variants in SCN2A , which encodes the NaV1.2 sodium channel critical for action potential initiation and propagation, are associated with autism spectrum disorder (ASD) and epilepsy. To investigate SCN2A deficiency–related pheno…
View article: Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids
Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids Open
Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2-L1342P, are monogenic causes of epilepsy. In this human-induced pluripotent stem cell model system, we aim to investigate the molecular and cellular mechanisms…
View article: Gene therapies alleviate absence epilepsy associated with <i>Scn2a</i> deficiency in DBA/2J mice
Gene therapies alleviate absence epilepsy associated with <i>Scn2a</i> deficiency in DBA/2J mice Open
Mutations in the voltage-gated sodium channel gene SCN2A , which encodes the Na V 1.2 channel, cause severe epileptic seizures. Patients with SCN2A loss-of-function (LoF) mutations, such as protein-truncating mutations, often experience la…
View article: Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloids
Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloids Open
Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organo…
View article: Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloids
Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloids Open
SUMMARY Profound autism spectrum disorder (ASD) is frequently attributable to single-gene mutations, with SCN2A (voltage-gated sodium channel Na V 1.2) protein-truncating variants (PTVs) being one of the most penetrant. Although cortico-st…
View article: Alzheimer’s disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery
Alzheimer’s disease patient brain extracts induce multiple pathologies in novel vascularized neuroimmune organoids for disease modeling and drug discovery Open
View article: Direct upcycling of degraded NCM <i>via</i> low-temperature surface engineering for high performance lithium-ion batteries
Direct upcycling of degraded NCM <i>via</i> low-temperature surface engineering for high performance lithium-ion batteries Open
This paper introduces the upcycling process of degraded NCM particles via surface engineering to restore the crystal structure, enhance the electrochemical performance, and improve the thermal stability.
View article: Persistently elevated AD risk in hiPSC‐derived cortical neurons after developmental and adult Pb exposure
Persistently elevated AD risk in hiPSC‐derived cortical neurons after developmental and adult Pb exposure Open
Background Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental periods and even in adult stage can result in adverse health outcomes later in life. Human cohort studies have demonstrated associations betwe…
View article: Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery
Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery Open
Alzheimer’s Disease (AD) is the most common cause of dementia afflicting 55 million individuals worldwide, with limited treatment available. Current AD models mainly focus on familial AD (fAD), which is due to genetic mutations. However, m…
View article: Impacts of Nucleosome Positioning Elements and Pre-Assembled Chromatin States on Expression and Retention of Transgenes
Impacts of Nucleosome Positioning Elements and Pre-Assembled Chromatin States on Expression and Retention of Transgenes Open
Background/Objectives: Transgene applications, ranging from gene therapy to the development of stable cell lines and organisms, rely on maintaining the expression of transgenes. To date, the use of plasmid-based transgenes has been limited…
View article: Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) Mixtures
Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) Mixtures Open
Arsenic (As) and lead (Pb) are environmental pollutants found in common sites linked to similar adverse health effects. This study determined driving factors of neurotoxicity on the developing cerebral vasculature with As and Pb mixture ex…
View article: Impacts of nucleosome positioning elements and pre-assembled chromatin states on expression and retention of transgenes
Impacts of nucleosome positioning elements and pre-assembled chromatin states on expression and retention of transgenes Open
Transgene applications ranging from gene therapy to development of stable cell lines and organisms rely on maintaining expression of transgenes. To-date, the use of plasmid-based transgenes has been limited by loss of their expression shor…
View article: Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons
Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons Open
View article: Corrigendum to “Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine” [Sci. Total Environ. 908 2024: Article 168307]
Corrigendum to “Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine” [Sci. Total Environ. 908 2024: Article 168307] Open
View article: Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine
Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazine Open
View article: Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation Open
Neuronal hyperexcitability is a hallmark of seizures. It has been recently shown in rodent models of seizures that microglia, the brain’s resident immune cells, can respond to and modulate neuronal excitability. However, how human microgli…
View article: CCDC 2266804: Experimental Crystal Structure Determination
CCDC 2266804: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2266800: Experimental Crystal Structure Determination
CCDC 2266800: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2266802: Experimental Crystal Structure Determination
CCDC 2266802: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2291655: Experimental Crystal Structure Determination
CCDC 2291655: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids Open
Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36 children in the United States. While neurons have been the focus to understand ASD, an altered neuro-immune response in the brain may be closely associ…
View article: Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells
Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells Open
Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophil-like cells via suppressing Rac activation. Here, we show…
View article: Author response: Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells
Author response: Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstr…
View article: Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons
Developmental Pb exposure increases AD risk via altered intracellular Ca2+ homeostasis in hiPSC-derived cortical neurons Open
View article: Reduced Energetic Disorders in Dion–Jacobson Perovskites for Efficient and Spectral Stable Blue LEDs
Reduced Energetic Disorders in Dion–Jacobson Perovskites for Efficient and Spectral Stable Blue LEDs Open
Metal halide perovskites have witnessed great success in green, red, and near‐infrared light‐emitting diodes (LEDs), yet blue LEDs still lag behind. Reducing undesired energetic disorders – broad n ‐phases and halide segregation – is consi…
View article: Electroacupuncture Induces Bilateral S1 and ACC Epigenetic Regulation of Genes in a Mouse Model of Neuropathic Pain
Electroacupuncture Induces Bilateral S1 and ACC Epigenetic Regulation of Genes in a Mouse Model of Neuropathic Pain Open
Clinical and animal studies have shown that acupuncture may benefit controlling neuropathic pain. However, the underlying molecular mechanisms are poorly understood. In a well-established mouse unilateral tibial nerve injury (TNI) model, w…
View article: Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells
Atypical peripheral actin band formation via overactivation of RhoA and Non-muscle myosin II in Mitofusin 2 deficient cells Open
Cell spreading and migration play central roles in many physiological and pathophysiological processes. We have previously shown that MFN2 regulates the migration of human neutrophillike cells via suppressing Rac activation. Here, we show …
View article: DNA damage reduces heterogeneity and coherence of chromatin motions
DNA damage reduces heterogeneity and coherence of chromatin motions Open
Chromatin motions depend on and may regulate genome functions, in particular the DNA damage response. In yeast, DNA double-strand breaks (DSBs) globally increase chromatin diffusion, whereas in higher eukaryotes the impact of DSBs on chrom…