Chenye Shen
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View article: Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling
Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling Open
SUMMARY The Calcitonin gene-related peptide (CGRP) receptor has gained attention in Alzheimer’s Disease (AD) research due to its involvement in regulating neuroinflammation. However, its role and mechanism in AD pathology remain unclear. H…
View article: Regional adiposity shapes brain and cognition in adults
Regional adiposity shapes brain and cognition in adults Open
View article: Dedifferentiation of brain functional gradient captures cognition performance and stroke occurrence: A UK Biobank study
Dedifferentiation of brain functional gradient captures cognition performance and stroke occurrence: A UK Biobank study Open
Brain functional dedifferentiation, marked by reduced specificity of brain activity or greater similarity of functional connectivity (FC) among networks, is a hallmark of aging. Traditionally, task functional magnetic resonance imaging stu…
View article: Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease
Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson’s disease Open
View article: The causal relationship between 25-hydroxyvitamin D and serum lipids levels: A bidirectional two-sample mendelian randomization study
The causal relationship between 25-hydroxyvitamin D and serum lipids levels: A bidirectional two-sample mendelian randomization study Open
Serum vitamin D levels were linked to lipid metabolism in observational studies, but the exact mechanism was unclear. Several studies have attempted to decipher the relationship between 25(OH)D and lipid levels. Conventional observational …
View article: Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study
Metabolism-related brain morphology accelerates aging and predicts neurodegenerative diseases and stroke: a UK Biobank study Open
s Metabolic syndrome (MetS) is characterized by a constellation of metabolic risk factors, including obesity, hypertriglyceridemia, low high-density lipoprotein (HDL) levels, hypertension, and hyperglycemia, and is associated with stroke a…
View article: Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study
Amyloid-β accumulation in relation to functional connectivity in aging: A longitudinal study Open
View article: NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models
NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson’s disease models Open
Parkinson’s disease (PD) is mainly characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and neuroinflammation mediated by overactivated microglia and astrocytes. NLRC5 (nucleoti…
View article: Factors correlated with targeted prevention for prediabetes classified by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c: A population-based longitudinal study
Factors correlated with targeted prevention for prediabetes classified by impaired fasting glucose, impaired glucose tolerance, and elevated HbA1c: A population-based longitudinal study Open
Background There is still controversy surrounding the precise characterization of prediabetic population. We aim to identify and examine factors of demographic, behavioral, clinical, and biochemical characteristics, and obesity indicators …
View article: Association of sleep duration and sleep quality with the risk of metabolic syndrome in adults: a systematic review and meta-analysis
Association of sleep duration and sleep quality with the risk of metabolic syndrome in adults: a systematic review and meta-analysis Open
Our results demonstrated that short sleep duration increased the risk of developing MetS. Long sleep duration was also associated with MetS, especially for 11 h. 8.5 h can be considered the recommended sleep duration for MetS. Poor sleep q…
View article: Dimensionality Reduction of Local Field Potential Features with Convolution Neural Network in Neural Decoding: A Pilot Study
Dimensionality Reduction of Local Field Potential Features with Convolution Neural Network in Neural Decoding: A Pilot Study Open
Local field potentials (LFPs) have better long-term stability compared with spikes in brain-machine interfaces (BMIs). Many studies have shown promising results of LFP decoding, but the high-dimensional feature of LFP still hurdle the deve…
View article: Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease
Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease Open
Objectives Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive and selective degeneration of dopaminergic neurons. Microglial activation and neuroinflammation are associated with the pathogenesi…
View article: NRSF/REST Deficiency Impairs Cognitive Abilities in Aged Mice But Does Not Interfere with Memory Deficits of APP/PS1 Transgenic Mice
NRSF/REST Deficiency Impairs Cognitive Abilities in Aged Mice But Does Not Interfere with Memory Deficits of APP/PS1 Transgenic Mice Open