Chunyu Cao
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View article: Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis.
Therapeutic potential of AAV8-mediated IL-17RA extracellular domain gene delivery in an imiquimod-induced mouse model of psoriasis. Open
AAV8-mediated IL-17RA(ECD) gene delivery effectively blocks cutaneous inflammation and attenuates inflammatory cytokines overexpression in an IMQ-induced mouse model of psoriasis, highlighting its therapeutic potential for chronic inflamma…
View article: Expression, prognostic potential, and regulatory mechanism of SERPINE1 in digestive system cancer
Expression, prognostic potential, and regulatory mechanism of SERPINE1 in digestive system cancer Open
View article: The dual guardians of cellular stability: exploring nesprin and lamin in senescence
The dual guardians of cellular stability: exploring nesprin and lamin in senescence Open
View article: Effects of silencing or overexpression of ZIP3 and ZIP5 on zinc absorption as zinc sulfate or zinc proteinate and related gene expressions in primary duodenal epithelial cells of broilers
Effects of silencing or overexpression of ZIP3 and ZIP5 on zinc absorption as zinc sulfate or zinc proteinate and related gene expressions in primary duodenal epithelial cells of broilers Open
View article: Enhanced SLC2A4 expression mitigates insulin resistance in gestational diabetes mellitus via the FoxO signaling pathway <i>in vitro</i>
Enhanced SLC2A4 expression mitigates insulin resistance in gestational diabetes mellitus via the FoxO signaling pathway <i>in vitro</i> Open
Gestational diabetes mellitus (GDM), a type of diabetes mellitus occurring in pregnant women, increases the risk of birth trauma. Solute carrier family 2 member 4 (SLC2A4) polymorphism is notably associated with GDM susceptibility; however…
View article: Therapies targeting triple-negative breast cancer: a perspective on anti-FGFR
Therapies targeting triple-negative breast cancer: a perspective on anti-FGFR Open
Triple-negative breast cancer (TNBC) is one of the subtypes with the worst prognosis due to tumour heterogeneity and lack of appropriate treatment. This condition is a consequence of the distinctive tumour microenvironment (TME). The TME i…
View article: Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy
Single-nucleus RNA sequencing reveals ARHGAP28 expression of podocytes as a biomarker in human diabetic nephropathy Open
Introduction Diabetic kidney disease (DKD) represents serious diabetes-associated complications, and podocyte loss is an important histologic sign of DKD. The cellular and molecular profiles of podocytes in DKD have yet to be fully elucida…
View article: Advances in tumor-infiltrating B lymphocytes
Advances in tumor-infiltrating B lymphocytes Open
In the landscape of tumor immunotherapy, T cell-mediated immune responses have consistently captured the attention, while the contributions of B cells have been neglected. Nevertheless, growing evidence underscores the pivotal role of tumo…
View article: Determination of Standardized Mineral Availabilities in Different Sources of Corns for Broilers and Establishment of Their Predicting Models
Determination of Standardized Mineral Availabilities in Different Sources of Corns for Broilers and Establishment of Their Predicting Models Open
View article: Dissecting the association between breast cancer and scar conditions and fibrosis of skin : a bidirectional Mendelian randomization study
Dissecting the association between breast cancer and scar conditions and fibrosis of skin : a bidirectional Mendelian randomization study Open
Background Scar hyperplasia and skin fibrosis following breast cancer operation has long been recognized as one of the major effects affecting patients' quality of life. However, there is currently a lack of direct evidence examining the i…
View article: [A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice].
[A recombinant adeno-associated virus expressing secretory TGF-β type Ⅱ receptor inhibits triple-negative murine breast cancer 4T1 cell proliferation and lung metastasis in mice]. Open
The recombinant AVV2 vector encoding sTβRⅡ extracellular domain is capable of blocking the TGF-β signaling pathway to inhibit the proliferation and lung metastasis of 4T1 cells in mice.
View article: Zinc alleviates thermal stress-induced damage to the integrity and barrier function of cultured chicken embryonic primary jejunal epithelial cells via the MAPK and PI3K/AKT/mTOR signaling pathways
Zinc alleviates thermal stress-induced damage to the integrity and barrier function of cultured chicken embryonic primary jejunal epithelial cells via the MAPK and PI3K/AKT/mTOR signaling pathways Open
View article: Identification of AAV serotypes for gene therapy in Krabbe iPSCs-derived brain organoids
Identification of AAV serotypes for gene therapy in Krabbe iPSCs-derived brain organoids Open
View article: PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors
PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors Open
Although recombinant human TNF-related apoptosis-inducing ligand (TRAIL) protein exhibits antitumor activity in a number of lung and liver cancer cells and tumor-bearing animals, TRAIL resistance has substantially restricted its clinical a…
View article: Zinc proteinate with moderate chelation strength enhances zinc absorption by upregulating the expression of zinc and amino acid transporters in primary cultured duodenal epithelial cells of broiler embryos
Zinc proteinate with moderate chelation strength enhances zinc absorption by upregulating the expression of zinc and amino acid transporters in primary cultured duodenal epithelial cells of broiler embryos Open
Recent study showed that zinc (Zn) and amino acid transporters may be involved in enhancing Zn absorption from Zn proteinate with moderate chelation strength (Zn-Prot M) in the duodenum of broilers. However, the specific mechanisms by whic…
View article: Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2
Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2 Open
View article: Glutamate secretion by embryonic stem cells as an autocrine signal to promote proliferation
Glutamate secretion by embryonic stem cells as an autocrine signal to promote proliferation Open
View article: Rehmannioside A Inhibits TRAF6/MAPK Pathway and Improves Psoriasis by Interfering with the Interaction of HaCaT Cells with IL-17A
Rehmannioside A Inhibits TRAF6/MAPK Pathway and Improves Psoriasis by Interfering with the Interaction of HaCaT Cells with IL-17A Open
ReA has in vitro anti-psoriatic effects and may be a new therapeutic agent for psoriasis.
View article: Glutamate Secretion by Embryonic Stem Cells as an Autocrine Signal to Promote Proliferation
Glutamate Secretion by Embryonic Stem Cells as an Autocrine Signal to Promote Proliferation Open
Glutamate, the major excitatory neurotransmitter in the central nervous system, has also been found to play a role in embryonic stem (ES) cells. However, the exact mechanism and function of glutamatergic signaling in ES cells remain poorly…
View article: rAAV2-Mediated Restoration of GALC in Neural Stem Cells from Krabbe Patient-Derived iPSCs
rAAV2-Mediated Restoration of GALC in Neural Stem Cells from Krabbe Patient-Derived iPSCs Open
Krabbe disease is a rare neurodegenerative fatal disease. It is caused by deficiency of the lysosomal enzyme galactocerebrosidase (GALC), which results in progressive accumulation of galactolipid substrates in myelin-forming cells. However…
View article: Identifying altered developmental pathways in human globoid cell leukodystrophy iPSCs-derived NSCs using transcriptome profiling
Identifying altered developmental pathways in human globoid cell leukodystrophy iPSCs-derived NSCs using transcriptome profiling Open
View article: Generation and characterization of iPS cell line (CTGUi001-A) from skin fibroblasts of a patient with Fabry disease
Generation and characterization of iPS cell line (CTGUi001-A) from skin fibroblasts of a patient with Fabry disease Open
We have generated an iPSCs line (CTGUi001-A) from dermal fibroblasts of a 16-year-old male Fabry disease patient with a novel GLA gene mutation (c.156C > A) using Sendai virus encoding the four Yamanaka factors OCT4, SOX2, KLF4, and c-MYC.…
View article: The Zinc Proteinate with Moderate Chelation Strength Enhances Zinc Absorption Possibly by Up-Regulating Expression of Related Transporters in Primary Cultured Duodenal Epithelial Cells of Broiler Embryos
The Zinc Proteinate with Moderate Chelation Strength Enhances Zinc Absorption Possibly by Up-Regulating Expression of Related Transporters in Primary Cultured Duodenal Epithelial Cells of Broiler Embryos Open
View article: Overexpression of Mtr-miR319a Contributes to Leaf Curl and Salt Stress Adaptation in Arabidopsis thaliana and Medicago truncatula
Overexpression of Mtr-miR319a Contributes to Leaf Curl and Salt Stress Adaptation in Arabidopsis thaliana and Medicago truncatula Open
Salt stress is a worldwide agronomic issue that limits crop yield and quality. Improving salt stress tolerance via genetic modification is the most efficient method to conquer soil salinization problems in crops. Crop miRNAs have been decl…
View article: Red ginseng extract improves skeletal muscle energy metabolism and mitochondrial function in chronic fatigue mice
Red ginseng extract improves skeletal muscle energy metabolism and mitochondrial function in chronic fatigue mice Open
Background: Skeletal muscles are organs with high energy requirements, especially during vigorous exercise. Adequate mitochondrial function is essential to meet the high energy needs of skeletal muscle cells. Recent studies have reported t…
View article: Coffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction]
Coffee and Caffeine Potentiate the Antiamyloidogenic Activity of Melatonin via Inhibition of Aβ Oligomerization and Modulation of theTau-Mediated Pathway in N2a/APP Cells [Retraction] Open
Zhang LF, Zhou ZW, Wang ZH, et al. Drug Des Devel Ther. 2014;9:241–272. The Editor and Publisher of Drug Design, Development and Therapy wish to retract the published article. Concerns were raised regarding the alleged duplication of bands…
View article: Production and characterization of human induced pluripotent stem cell line (PUMCi002-A) from a Krabbe patient related control to study disease mechanisms associated with GALC mutation
Production and characterization of human induced pluripotent stem cell line (PUMCi002-A) from a Krabbe patient related control to study disease mechanisms associated with GALC mutation Open
View article: [Prokaryotic expression of a recombinant protein of adeno-associated virus capsid conserved regions and preparation of its polyclonal antibody].
[Prokaryotic expression of a recombinant protein of adeno-associated virus capsid conserved regions and preparation of its polyclonal antibody]. Open
We successfully obtained the polyclonal antibodies against AAV capsid conserved region protein from rabbits, which facilitate future studies of AAV vector development and the biological functions of AAV.
View article: Primary Fat-forming solitary fibrous tumor with focal atypical features of the breast. A case report and literature review
Primary Fat-forming solitary fibrous tumor with focal atypical features of the breast. A case report and literature review Open
Background : Primary solitary fibrous tumor (SFT) in breast is rare, while breast fat-forming solitary fibrous tumor (FFSFT) is even more rare in clinic. Here we reported a case of FFSFT with focal atypical features of the left breast, and…
View article: Selection of Adeno-Associated Virus Serotypes For Gene Therapy In Krabbe Patient IPSCs-Derived NSCs
Selection of Adeno-Associated Virus Serotypes For Gene Therapy In Krabbe Patient IPSCs-Derived NSCs Open
Krabbe disease is caused by the mutation or deficiency of galactocerebrosidase (GALC) enzyme, which is located in the lysosome and hydrolyzes the galactolipid substrates like psychosine. Psychosine would accumulate abnormally in the myelin…