Chunyang Cao
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View article: A Hybrid G-Quadruplex Structure Formed by a Sequence from the MAX Gene
A Hybrid G-Quadruplex Structure Formed by a Sequence from the MAX Gene Open
View article: Molecular recognition and effects of a benzothiazole derivative targeting the <i>MYC</i> G-quadruplex
Molecular recognition and effects of a benzothiazole derivative targeting the <i>MYC</i> G-quadruplex Open
Small-molecule intervention and stabilization of G-quadruplexes (G4s) have been investigated for the potential as therapeutic approaches. MYC plays diverse roles in cellular functions, making it a highly desirable yet challenging target. O…
View article: Federated Learning for AI-Assisted Education: Privacy-Preserving and Cross-Platform Collaborative Modeling in Higher Education
Federated Learning for AI-Assisted Education: Privacy-Preserving and Cross-Platform Collaborative Modeling in Higher Education Open
View article: Plasma membrane-associated calcium signaling modulates zinc homeostasis in Arabidopsis
Plasma membrane-associated calcium signaling modulates zinc homeostasis in Arabidopsis Open
Zinc (Zn) is a crucial micronutrient for all organisms, and its deficiency can significantly hamper crop yield and quality. However, the understanding of the regulatory mechanisms involved in plant Zn signal perception and transduction rem…
View article: Different DNA Binding and Damage Mode between Anticancer Antibiotics Trioxacarcin A and LL-D49194α1
Different DNA Binding and Damage Mode between Anticancer Antibiotics Trioxacarcin A and LL-D49194α1 Open
Trioxacarcin A (TXN) is a highly potent cytotoxic antibiotic with remarkable structural complexity. The crystal structure of TXN bound to double-stranded DNA (dsDNA) suggested that the TXN interaction might depend on positions of two sugar…
View article: Stable G quadruplex formed in promoter region of oncogene RET in physiological solution conditions
Stable G quadruplex formed in promoter region of oncogene RET in physiological solution conditions Open
The promoter region of proto-oncogene RET has continuous guanine-rich regions I–V, which form G-quadruplex (G4) structures. Reported RET20T G4 in the regions II–V has parallel folding in potassium-ion solutions; however, this G4-DNA is not…
View article: A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy Open
View article: Development of charybdotoxin <scp>Q18F</scp> variant as a selective peptide blocker of neuronal <scp>BK</scp>(α + β4) channel for the treatment of epileptic seizures
Development of charybdotoxin <span>Q18F</span> variant as a selective peptide blocker of neuronal <span>BK</span>(α + β4) channel for the treatment of epileptic seizures Open
Epilepsy is the results from the imbalance between inhibition and excitation in neural circuits, which is mainly treated by some chemical drugs with side effects. Gain‐of‐function of BK channels or knockout of its β4 subunit associates wit…
View article: NMR assisted studies on the solution structures and functions of antimicrobial peptides
NMR assisted studies on the solution structures and functions of antimicrobial peptides Open
View article: Aromatic disulfides as potential inhibitors against interaction between deaminase APOBEC3G and HIV infectivity factor
Aromatic disulfides as potential inhibitors against interaction between deaminase APOBEC3G and HIV infectivity factor Open
APOBEC3G (A3G) is a member of cytosine deaminase family with a variety of innate immune functions. It displays activities against retrovirus and retrotransposon by inhibition of virus infectivity factor (Vif)-deficient HIV-1 replication. T…
View article: Research Progress of Antiviral Drug Targeting the Main Protease of SARS-CoV-2
Research Progress of Antiviral Drug Targeting the Main Protease of SARS-CoV-2 Open
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 in late 2019 posed a serious threat to the world population.Some effective vaccines are currently approved and widely used, but the long-term efficacy and safety of this inte…
View article: Two different kinds of interaction modes of deaminase <scp>APOBEC3A</scp> with single‐stranded <scp>DNA</scp> in solution detected by nuclear magnetic resonance
Two different kinds of interaction modes of deaminase <span>APOBEC3A</span> with single‐stranded <span>DNA</span> in solution detected by nuclear magnetic resonance Open
APOBEC3A (A3A) deaminates deoxycytidine in target motif TC in a single‐stranded DNA (we termed it as TC DNA), which mortally mutates viral pathogens and immunoglobulins, and leads to the diversification and lethality of cancers. The crysta…
View article: Structure- and Mechanism-Based Research Progress of Anti-acquired Immune Deficiency Syndrome Drugs
Structure- and Mechanism-Based Research Progress of Anti-acquired Immune Deficiency Syndrome Drugs Open
View article: Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast
Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast Open
View article: Author Correction: Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity
Author Correction: Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity Open
View article: Selective Blockade of Neuronal BK (α + β4) Channels Preventing Epileptic Seizure
Selective Blockade of Neuronal BK (α + β4) Channels Preventing Epileptic Seizure Open
Gain-of-function of BK channels or knockout of their β4 subunit is associated with spontaneous epilepsy. Currently, efficacy of BK (α + β4) channel modulators in preventing epilepsy was never reported. Here, we show that martentoxin select…
View article: Investigating the interactions between DNA and DndE during DNA phosphorothioation
Investigating the interactions between DNA and DndE during DNA phosphorothioation Open
The DNA phosphorothioate modification is a novel physiological variation in bacteria. DndE controls this modification by binding to dsDNA via a mechanism that remains unclear. Structural analysis of the wild‐type DndE tetramer suggests tha…
View article: Correction: A putative G-quadruplex structure in the proximal promoter of VEGFR-2 has implications for drug design to inhibit tumor angiogenesis.
Correction: A putative G-quadruplex structure in the proximal promoter of VEGFR-2 has implications for drug design to inhibit tumor angiogenesis. Open
VOLUME 293 (2018) PAGES 8947–8955 There was an error in the grant footnote. The project number 2017YPE0108200 supported by the National Key R&D Program of China should be corrected to 2017YFE0108200.
View article: Selective recognition of<i>c-MYC</i>Pu22 G-quadruplex by a fluorescent probe
Selective recognition of<i>c-MYC</i>Pu22 G-quadruplex by a fluorescent probe Open
Nucleic acid mimics of fluorescent proteins can be valuable tools to locate and image functional biomolecules in cells. Stacking between the internal G-quartet, formed in the mimics, and the exogenous fluorophore probes constitutes the bas…
View article: Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel
Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel Open
Large-conductance Ca2+-activated K+ (BK) channels are composed of a pore-forming α and a variable number of auxiliary β subunits and play important roles in regulating excitability, action potential waveforms and firi…
View article: High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads
High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads Open
DNA can form diverse structures, which predefine their physiological functions. Besides duplexes that carry the genetic information, quadruplexes are the most well-studied DNA structures. In addition to their important roles in recombinati…
View article: Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1
Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1 Open
View article: A putative G-quadruplex structure in the proximal promoter of VEGFR-2 has implications for drug design to inhibit tumor angiogenesis
A putative G-quadruplex structure in the proximal promoter of VEGFR-2 has implications for drug design to inhibit tumor angiogenesis Open
View article: Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity
Solution structure of extracellular loop of human β4 subunit of BK channel and its biological implication on ChTX sensitivity Open
Large-conductance Ca 2+ - and voltage-dependent K + (BK) channels display diverse biological functions while their pore-forming α subunit is coded by a single Slo1 gene. The variety of BK channels is correlated with the effects of BKα coex…
View article: NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway
NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway Open
As an AAA-ATPase, Vps4 is important for function of multivesicular bodies (MVB) sorting pathway, which involves in cellular phenomena ranging from receptor down-regulation to viral budding to cytokinesis. The activity of Vps4 is stimulated…
View article: Structural investigation into physiological DNA phosphorothioate modification
Structural investigation into physiological DNA phosphorothioate modification Open
View article: Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition Open
View article: Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis
Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis Open
View article: Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptide
Crystallographic analysis of NosA, which catalyzes terminal amide formation in the biosynthesis of nosiheptide Open
Nosiheptide is a member of the thiopeptide family of antibiotics which demonstrates potent activities against various bacterial pathogens. The formation of its C-terminal amide is catalysed by NosA in an unusual strategy for maturating cer…