Explanipedia

Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH Open

Xiaodong Yu, Chenyuan Huang, Martijn J.W. Evers, Jingjing Liu, Hui Jun Ting , et al. · 2025

Increasing evidence implicates ceramides in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH). However, the therapeutic potential of liver-targeted ceramide lowering remains unclear. In this study, we demonstrate …

Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile Open

Claudia Carrera-Bravo, Tianchi Zhou, Trang T. T. Chu, Jing Wen Hang, Harshvardhan Modh , et al. · 2025

Introduction Malaria is a vector-borne parasitic disease that affects millions worldwide. To achieve the objective set by the World Health Organization of reducing malaria cases by 2030, antimalarial drugs with novel modes of action are re…

Polydopamine and hyaluronic acid-coated dual-responsive silica nanoparticles for targeted atherosclerosis imaging and therapy Open

Yuanzhe Lin, Chenyuan Huang, Xiao Hou, James Chen Yong Kah, Jiong‐Wei Wang · 2025

An NB/SPDA@HA nanotheranostic platform, responsive to both acidic conditions and hyaluronidase, is proposed for photoacoustic imaging-guided therapy of atherosclerosis.

Dual‐Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis Open

Yuanzhe Lin, Jingjing Liu, Suet Yen Chong, Hui Jun Ting, Xichuan Tang , et al. · 2024

Atherosclerosis is the primary cause of cardiovascular events such as heart attacks and strokes. However, current medical practice lacks non‐invasive, reliable approaches for both imaging atherosclerotic plaques and delivering therapeutic …

Extracellular Vesicles and Their Mimetics: A Comparative Study of Their Pharmacological Activities and Immunogenicity Profiles Open

Wei Heng Chng, Ram Pravin Kumar Muthuramalingam, Charles Kang Liang Lou, Silas New, Yub Raj Neupane , et al. · 2023

Extracellular vesicles (EVs), which are miniaturised carriers loaded with functional proteins, lipids, and nucleic acid material, are naturally secreted by cells and show intrinsic pharmacological effects in several conditions. As such, th…

Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis Open

Lingjun Tong, Sitong Zhang, Qiqi Liu, Chenyuan Huang, Haining Hao , et al. · 2023

Milk-derived extracellular vesicles (mEVs) have been proposed as a potential nanomedicine for intestinal disorders; however, their impact on intestinal barrier integrity in gut inflammation and associated metabolic diseases has not been ex…

Temporal Changes in Extracellular Vesicle Hemostatic Protein Composition Predict Favourable Left Ventricular Remodeling after Acute Myocardial Infarction Open

Xiong Chang Lim, Chenyuan Huang, Siti Maryam J. M. Yatim, Suet Yen Chong, Sock Hwee Tan , et al. · 2022

The subset of plasma extracellular vesicles (EVs) that coprecipitate with low-density lipoprotein (LDL-EVs) carry coagulation and fibrinolysis pathway proteins as cargo. We investigated the association between LDL-EV hemostatic/fibrinolysi…

Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing Open

Yub Raj Neupane, Harish K. Handral, Syed Abdullah Alkaff, Wei Heng Chng, Gopalakrishnan Venkatesan , et al. · 2022

The synthesis of extracellular vesicles by the protistan parasite Blastocystis Open

Steven Santino Leonardi, Eileen Y. Koh, Lei Deng, Chenyuan Huang, Lingjun Tong , et al. · 2022

Blastocystis is a genus of single-celled protist belonging to the stramenopile group. Prior studies have shown that isolates of Blastocystis subtype 7 (ST7) induced higher levels of intestinal epithelial cell damage and gut microbiota dysb…

Investigations on Cellular Uptake Mechanisms and Immunogenicity Profile of Novel Bio-Hybrid Nanovesicles Open

Yi-Hsuan Ou, Jeremy Liang, Wei Heng Chng, Ram Pravin Kumar Muthuramalingam, Zi Xiu Ng , et al. · 2022

In drug delivery, the development of nanovesicles that combine both synthetic and cellular components provides added biocompatibility and targeting specificity in comparison to conventional synthetic carriers such as liposomes. Produced th…

Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived Nanovesicles Open

Yub Raj Neupane, Chenyuan Huang, Xiaoyuan Wang, Wei Heng Chng, Gopalakrishnan Venkatesan , et al. · 2021

Recently, bioinspired cell-derived nanovesicles (CDNs) have gained much interest in the field of nanomedicine due to the preservation of biomolecular structure characteristics derived from their parent cells, which impart CDNs with unique …

Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice Open

Elise L. Kessler, Jiong‐Wei Wang, Bart Kok, Maike A. D. Brans, Angelique Nederlof , et al. · 2021

Involvement of the Toll-like receptor 4 (TLR4) in maladaptive cardiac remodeling and heart failure (HF) upon pressure overload has been studied extensively, but less is known about the role of TLR2. Interplay and redundancy of TLR4 with TL…

Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis Open

J W Wang, Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xue Wang , et al. · 2021

Introduction The coagulation protein tissue factor (TF) regulates inflammation and angiogenesis via its cytoplasmic domain in infection, cancer and diabetes. While TF is highly abundant in the heart and implicated in cardiac injuries and d…

Lyophilization Preserves the Intrinsic Cardioprotective Activity of Bioinspired Cell-Derived Nanovesicles Open

Yub Raj Neupane, Chenyuan Huang, Xiaoyuan Wang, Wei Heng Chng, Gopalakrishnan Venkatesan , et al. · 2021

Recently, bioinspired cell-derived nanovesicles (CDNs) have gained much interest in the field of nanomedicine due to the preservation of biomolecular structure characteristics derived from their parent cells, which impart CDNs with unique …

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies Open

Pol Escudé Martinez de Castilla, Lingjun Tong, Chenyuan Huang, Alexandros Marios Sofias, Giorgia Pastorin , et al. · 2021

Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis Open

Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim , et al. · 2021

The coagulation protein tissue factor (TF) regulates inflammation and angiogenesis via its cytoplasmic domain in infection, cancer and diabetes. While TF is highly abundant in the heart and is implicated in cardiac pathology, the contribut…

Extracellular Vesicles in Cardiovascular Diseases: Alternative Biomarker Sources, Therapeutic Agents, and Drug Delivery Carriers Open

Suet Yen Chong, Choon Keong Lee, Chenyuan Huang, Yi Ou, Christopher J. Charles , et al. · 2019

Cardiovascular diseases (CVD) represent the leading cause of morbidity and mortality globally. The emerging role of extracellular vesicles (EVs) in intercellular communication has stimulated renewed interest in exploring the potential appl…

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