Chenyu Sun
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View article: DNA methylation-driven gene-based drug response prediction model for liver cancer: The critical role of GLS
DNA methylation-driven gene-based drug response prediction model for liver cancer: The critical role of GLS Open
Background Aberrant DNA methylation plays a pivotal role in cancer progression by enhancing oncogene activation or silencing tumor suppressor genes, contributing to malignant phenotypes. Methylation driver genes (MDGs) are characterized by…
View article: Personality masks of mothers of young children: measure development and parenting behavior impact
Personality masks of mothers of young children: measure development and parenting behavior impact Open
This study developed and validated an instrument to assess the personality masks of mothers of young children, addressing a gap in the developmental psychology. Using a mixed-methods approach grounded in Carl Jung’s theory of persona, we c…
View article: Investigating the Effects of Long-Term Fine Particulate Matter Exposure on Autism Spectrum Disorder Severity: Evidence from Multiple Analytical Approaches
Investigating the Effects of Long-Term Fine Particulate Matter Exposure on Autism Spectrum Disorder Severity: Evidence from Multiple Analytical Approaches Open
With rapid industrial expansion, air pollution’s adverse neurological effects have gained increasing attention. Children face a greater risk of neurological damage because of their higher breathing rates, developing brains, and limited abi…
View article: Disease burden of HIV and its behavioral risks among adults aged 20–54 years in China and the Western Pacific Region from 1990 to 2021: an analysis based on the Global Burden of Disease Study 2021
Disease burden of HIV and its behavioral risks among adults aged 20–54 years in China and the Western Pacific Region from 1990 to 2021: an analysis based on the Global Burden of Disease Study 2021 Open
Background The HIV epidemic remains a significant public health concern among individuals aged 20–54 years. However, comprehensive studies evaluating trends in HIV-related health burdens and associated behavioral risks in China and the Wes…
View article: HG-PINN: A residual physics-informed neural network framework for heterogeneous groundwater flow simulation
HG-PINN: A residual physics-informed neural network framework for heterogeneous groundwater flow simulation Open
Accurately modeling groundwater flow in heterogeneous aquifers remains challenging due to spatial variability and boundary complexity. Physics-informed neural networks (PINNs) have shown advantages in groundwater flow modeling by embedding…
View article: Exploring the relationship between dietary index for gut microbiota and cognitive function
Exploring the relationship between dietary index for gut microbiota and cognitive function Open
Background Significant correlations exist between gut microbiota, dietary habits, and cognitive function; the objective of this research was to evaluate the correlation between the dietary index for gut microbiota (DI-GM) and cognitive per…
View article: Diagnostic immune-related markers for diabetic kidney disease: a bioinformatics and machine learning approach
Diagnostic immune-related markers for diabetic kidney disease: a bioinformatics and machine learning approach Open
ALB and FOS serve as novel immunogenetic biomarkers for DKD, highlighting chronic inflammation as a key driver. This framework supports precision immunomodulation, though clinical validation in larger cohorts is needed.
View article: Circulating tumor cell heterogeneity and MMP9 expression in clinical correlation with breast cancer
Circulating tumor cell heterogeneity and MMP9 expression in clinical correlation with breast cancer Open
Purpose This study aimed to investigate the association between the heterogeneity of circulating tumor cell (CTC) subtypes and the expression patterns of matrix metalloproteinase 9 (MMP9) with clinicopathological parameters in breast cance…
View article: Strand displacement‐driven CRISPR/Cas12a framework enables precise identification of low‐abundance point mutations
Strand displacement‐driven CRISPR/Cas12a framework enables precise identification of low‐abundance point mutations Open
Accurate identification of low‐abundance point mutations is a crucial technical challenge in clinical diagnosis, particularly within high wild‐type genomic backgrounds. We established an engineered Clustered Regularly Interspaced Short Pal…
View article: Association between age at first birth and cognitive function in women 60 years and older: the 2011–2014 cross-sectional National Health and Nutrition Examination Survey (NHANES) study
Association between age at first birth and cognitive function in women 60 years and older: the 2011–2014 cross-sectional National Health and Nutrition Examination Survey (NHANES) study Open
Later AFB is associated with a reduced prevalence of cognitive impairment and improved cognitive outcomes, particularly when the first birth occurs after age 21. Considering WHtR and WWI may further optimize the protective effects of AFB o…
View article: Mediating effect of social anxiety on the association between self-esteem and internet addiction among Chinese vocational school students
Mediating effect of social anxiety on the association between self-esteem and internet addiction among Chinese vocational school students Open
Introduction In today’s digital age, concerns about internet addiction among adolescents have escalated alongside the widespread use of the internet. Simultaneously, research has spotlighted the influence of psychological factors like self…
View article: Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery
Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery Open
Plant extracellular vesicles (PEVs) are nanoscale vesicles secreted by plant cells with intact membrane architecture, which encapsulate a diverse array of biomolecules, including lipids, proteins and RNA. They are integral to both intra‐ce…
View article: Evaluating Artificial Intelligence in Video Games: Background and Significance of the Study
Evaluating Artificial Intelligence in Video Games: Background and Significance of the Study Open
The article will discuss how artificial intelligence, increasingly used in the video game industry, has enhanced the process of game design and given players different ways to find entertainment. This is done in an effort to analyze the im…
View article: Global and China trends and forecasts of disease burden for female lung Cancer from 1990 to 2021: a study based on the global burden of disease 2021 database
Global and China trends and forecasts of disease burden for female lung Cancer from 1990 to 2021: a study based on the global burden of disease 2021 database Open
Although the overall disease burden of female lung cancer is not as high as that of males, the growth rate for female lung cancer is significantly higher than that for males both in China and globally. The overall disease burden and the gr…
View article: Special Issue: “Vaccination and Global Health”
Special Issue: “Vaccination and Global Health” Open
This Special Issue, titled ‘Vaccination and Global Health,’ compiles 11 broad-ranging papers, each exploring critical facets of vaccination, public health, and global healthcare systems [...]
View article: Anti-Rain Clutter Interference Method for Millimeter-Wave Radar Based on Convolutional Neural Network
Anti-Rain Clutter Interference Method for Millimeter-Wave Radar Based on Convolutional Neural Network Open
Millimeter-wave radars are widely used in various environments due to their excellent detection capabilities. However, the detection performance in severe weather environments is still an important research challenge. In this paper, the pr…
View article: Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway
Peimine induces apoptosis of glioblastoma cells through regulation of the PI3K/AKT signaling pathway Open
Glioblastoma (GBM) is one of the most malignant forms of intracranial tumors, with high mortality rates and invariably poor prognosis, due to the limited clinical treatment strategies available. As a natural compound, peimine's favorable p…
View article: Predicting the Future Capacity and Remaining Useful Life of Lithium-Ion Batteries Based on Deep Transfer Learning
Predicting the Future Capacity and Remaining Useful Life of Lithium-Ion Batteries Based on Deep Transfer Learning Open
Lithium-ion batteries are widely utilized in numerous applications, making it essential to precisely predict their degradation trajectory and remaining useful life (RUL). To improve the stability and applicability of RUL prediction for lit…
View article: Insights into the ameliorative effect of ZnONPs on arsenic toxicity in soybean mediated by hormonal regulation, transporter modulation, and stress responsive genes
Insights into the ameliorative effect of ZnONPs on arsenic toxicity in soybean mediated by hormonal regulation, transporter modulation, and stress responsive genes Open
Arsenic (As) contamination of agricultural soils poses a serious threat to crop productivity and food safety. Zinc oxide nanoparticles (ZnONPs) have emerged as a potential amendment for mitigating the adverse effects of As stress in plants…
View article: ZIPK collaborates with STAT5A in p53-mediated ROS accumulation in hyperglycemia-induced vascular injury
ZIPK collaborates with STAT5A in p53-mediated ROS accumulation in hyperglycemia-induced vascular injury Open
In this study we investigate the role of Zipper-interacting protein kinase (ZIPK) in high glucose-induced vascular injury, focusing on its interaction with STAT5A and its effects on p53 and inducible nitric oxide synthase (NOS2) expression…
View article: Consistency of CSCO AI with Multidisciplinary Clinical Decision-Making Teams in Breast Cancer: A Retrospective Study
Consistency of CSCO AI with Multidisciplinary Clinical Decision-Making Teams in Breast Cancer: A Retrospective Study Open
In the realm of breast cancer treatment, the alignment between recommendations offered by CSCO AI and those from MDT is predominant. CSCO AI can be a useful tool for breast cancer treatment decisions.
View article: How does factor market distortion affect green innovation? Evidence from China's sustainable development demonstration belt
How does factor market distortion affect green innovation? Evidence from China's sustainable development demonstration belt Open
Green innovation meets the simultaneous demands of green and innovation‐driven development models when it is deemed as a key to realizing a green economic transition. However, factor market distortion impedes China's green development thro…
View article: A one-year relapse prediction model for acute ischemic stroke (AIS) based on clinical big data
A one-year relapse prediction model for acute ischemic stroke (AIS) based on clinical big data Open
The nomogram model for stroke recurrence within one year developed in this study performed well. This useful tool can be used in clinical practice to provide important guidance to healthcare professionals.