Chenyun Wu
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View article: MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model
MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model Open
Background Alzheimer’s disease (AD) is the most common type of dementia. Genetic polymorphisms are associated with altered risks of AD onset, pointing to biological processes and potential targets for interventions. Consistent with the imp…
View article: Fos labels a distinct excitatory neuron ensemble for memory retrieval
Fos labels a distinct excitatory neuron ensemble for memory retrieval Open
Experience-triggered expression of Fos has been extensively used as a marker representing memory engram. It is generally assumed that Fos-positive neurons are preferentially excited by the experience, yet this has not been directly examine…
View article: Improving Orbit Prediction of the Two-Line Element with Orbit Determination Using a Hybrid Algorithm of the Simplex Method and Genetic Algorithm
Improving Orbit Prediction of the Two-Line Element with Orbit Determination Using a Hybrid Algorithm of the Simplex Method and Genetic Algorithm Open
With the rapidly increasing number of satellites and orbital debris, collision avoidance and reentry prediction are very important for space situational awareness. A precise orbital prediction through orbit determination is crucial to enha…
View article: TLE Orbit Determination Considering Time Variables
TLE Orbit Determination Considering Time Variables Open
View article: Protective effects of paeonol against cognitive impairment in lung diseases
Protective effects of paeonol against cognitive impairment in lung diseases Open
Pulmonary inflammation may lead to neuroinflammation resulting in neurological dysfunction, and it is associated with a variety of acute and chronic lung diseases. Paeonol is a herbal phenolic compound with anti-inflammatory and anti-oxida…
View article: PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury
PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury Open
Excessive host immune responses contribute to severe malaria with high mortality. Here, we show that PRL2 in innate immune cells is highly related to experimental malaria disease progression, especially the development of murine severe mal…
View article: Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes
Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes Open
Introduction Clonorchis sinensis infection results in various complications in the liver and biliary systems and is a neglected tropical disease in Eastern Asia. In this study, we report that C. sinensis calcium-binding protein Cs16 activa…
View article: HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction
HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction Open
View article: Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition
Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition Open
View article: Fault Diagnosis Methods and Fault Tolerant Control Strategies for the Electric Vehicle Powertrains
Fault Diagnosis Methods and Fault Tolerant Control Strategies for the Electric Vehicle Powertrains Open
With the challenges of global climate anomalies and energy crises, vehicle electrification has an increasing trend as an exciting solution for reducing greenhouse gas emissions and fossil fuel-based energy consumption [...]
View article: How well does CLIP understand texture?
How well does CLIP understand texture? Open
We investigate how well CLIP understands texture in natural images described by natural language. To this end, we analyze CLIP's ability to: (1) perform zero-shot learning on various texture and material classification datasets; (2) repres…
View article: Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE)
Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) Open
Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from Schistosoma japonicum eggs. It is a neutrophil attractant and mac…
View article: Primary pulmonary arterial sarcoma treated with endostar injection and radiotherapy
Primary pulmonary arterial sarcoma treated with endostar injection and radiotherapy Open
We present a case of primary pulmonary arterial sarcoma (PPAS) treated with endostatin (endostar) injection and radiotherapy discuss the diagnosis, clinical manifestations, and pathology of PPAS. The patient complained of cough with sputum…
View article: PRL2 serves as a negative regulator in cell adaptation to oxidative stress
PRL2 serves as a negative regulator in cell adaptation to oxidative stress Open
View article: PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS
PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS Open
Although it is well-recognized that inflammation enhances leukocyte bactericidal activity, the underlying mechanisms are not clear. Here we report that PRL2 is sensitive to oxidative stress at inflamed sites. Reduced PRL2 in phagocytes cau…