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View article: Interpretable deep learning predicts polycythemia vera and identifies novel genomic associations
Interpretable deep learning predicts polycythemia vera and identifies novel genomic associations Open
Lowering the haemoglobin cut-off for polycythaemia vera (PV) has markedly increased suspected PV referrals. Polycythemia Vera (PV) is a myeloproliferative neoplasm (MPN) marked by elevated red blood cell mass, typically driven by the JAK2 …
View article: Neurological fallout of mycophenolate: A PRES case
Neurological fallout of mycophenolate: A PRES case Open
View article: Diagnostic yield and outcomes of incidental thoracic aortic dilatation in the NHS targeted lung health check programme: novel insights from a regional tertiary centre in the United Kingdom
Diagnostic yield and outcomes of incidental thoracic aortic dilatation in the NHS targeted lung health check programme: novel insights from a regional tertiary centre in the United Kingdom Open
Background The NHS Targeted Lung Health Check (TLHC) programme in the UK screens individuals aged 55 to 74 with a smoking history for lung cancer using low-dose non-contrast computed tomography (LDCT). An increasing number of incidental fi…
View article: Hemophagocytic lymphohistiocytosis wildfire kindled by a tropical spark: a case report on HLH secondary to typhoid fever
Hemophagocytic lymphohistiocytosis wildfire kindled by a tropical spark: a case report on HLH secondary to typhoid fever Open
Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disorder of immune regulation that can rapidly progress to end-organ damage and death. HLH is characterised by uncontrolled activation of cytotoxic T lymphocytes, natu…
View article: Treatment challenges and outcomes of older patients with acute myeloid leukemia from India
Treatment challenges and outcomes of older patients with acute myeloid leukemia from India Open
Globally, overall survival (OS) of older patients with AML continues to be suboptimal with very little data from India. In a multicenter registry analysis, we evaluated 712 patients with AML older than 55 years. Only 323 (45.3%) underwent …
View article: A case report on bortezomib-induced paralytic ileus
A case report on bortezomib-induced paralytic ileus Open
Bortezomib is the first anticancer proteasome inhibitor used in the initial treatment of multiple myeloma in combination with cyclophosphamide and dexamethasone. Subcutaneous and intravenous forms of bortezomib are available. The common ad…
View article: The World Federation of Hemophilia World Bleeding Disorders Registry: insights from the first 10,000 patients
The World Federation of Hemophilia World Bleeding Disorders Registry: insights from the first 10,000 patients Open
View article: Response to: "Letter to the Editor– Observation on the article titled “Vaccine-induced thrombotic thrombocytopenia (VITT): first report from India”"
Response to: "Letter to the Editor– Observation on the article titled “Vaccine-induced thrombotic thrombocytopenia (VITT): first report from India”" Open
View article: Acute Myeloid Leukemia during the COVID Pandemic: Impact and the Indian Experience
Acute Myeloid Leukemia during the COVID Pandemic: Impact and the Indian Experience Open
The coronavirus (COVID -19) pandemic posed critical challenges for public health, research, diagnosis, and treatment globally. Beyond the existing challenges in the management of Acute Myeloid Leukemia (AML) in India; we hypothesized that …
View article: The Predictive Score for Patients Hospitalized With COVID-19 in Resource-Limited Settings
The Predictive Score for Patients Hospitalized With COVID-19 in Resource-Limited Settings Open
View article: THE COSTS OF TREATING PATIENTS WITH HEMATOLOGICAL DISEASES - AN INDIAN PERSPECTIVE
THE COSTS OF TREATING PATIENTS WITH HEMATOLOGICAL DISEASES - AN INDIAN PERSPECTIVE Open
BACKGROUND: Treatment costs factor majorly in health care decision making in developing economies. India which has a signicant out of pocket expenditure for health care is representative of such an economy. The treatment progress hailed i…
View article: “DISCLOSURE OF DIAGNOSIS IN PATIENTS WITH HAEMATOLOGICAL CANCERSEXPERIENCE FROM A TERTIARY CENTRE IN INDIA”
“DISCLOSURE OF DIAGNOSIS IN PATIENTS WITH HAEMATOLOGICAL CANCERSEXPERIENCE FROM A TERTIARY CENTRE IN INDIA” Open
Disclosure of diagnosis is a challenge for health care providers in India. (1) There is preference towards a family centred decision making in favour of a patient-centred process. Various socio-cultural factors are then at play in a doctor…
View article: Procedural pain and serious adverse events following Bone Marrow Aspiration and Biopsy: Experience from an academic center in India
Procedural pain and serious adverse events following Bone Marrow Aspiration and Biopsy: Experience from an academic center in India Open
Background: The bone marrow aspiration and biopsy (BMAB) is an important and frequent investigative procedure for hematological diseases. Although thought to be safe and well tolerated; data is limited on the complications and degree of pa…
View article: Multisystem inflammatory syndrome in a neonate with severe hemophilia - a diagnostic challenge in COVID times: a case report
Multisystem inflammatory syndrome in a neonate with severe hemophilia - a diagnostic challenge in COVID times: a case report Open
Background Multisystem Inflammatory Syndrome in Neonates (MIS-N) can occur following antenatal COVID- 19 infection in the mother. Here we report a rare case of a neonate with Hemophilia A and MIS-N. Case presentation A 2-day-old baby prese…
View article: Vaccine-induced thrombotic thrombocytopenia (VITT): first report from India
Vaccine-induced thrombotic thrombocytopenia (VITT): first report from India Open
View article: Vaccine Induced Thrombotic Thrombocytopenia (VITT): First report from India and utility of risk score for diagnosis in resource limited settings.
Vaccine Induced Thrombotic Thrombocytopenia (VITT): First report from India and utility of risk score for diagnosis in resource limited settings. Open
Vaccine induced thrombotic thrombocytopenia (VITT) is a rare but devastating adverse event following adenoviral vector based vaccinations for COVID-19. Guidance statements and available reports lack clarity on the choice of imaging modalit…
View article: Outcomes in adolescent and young adult acute lymphoblastic leukaemia: a report from the Indian Acute Leukaemia Research Database (INwARD) of the Hematology Cancer Consortium (HCC)
Outcomes in adolescent and young adult acute lymphoblastic leukaemia: a report from the Indian Acute Leukaemia Research Database (INwARD) of the Hematology Cancer Consortium (HCC) Open
Adolescent and young adult (AYA) patients with acute lymphoblastic leukaemia (ALL) have inferior survival when compared to children. The causes are multiple and include bad biology, differences in treatment approaches, and other complex so…
View article: Chronic Myeloid Leukemia with Solitary Extramedullary Bone Deposit
Chronic Myeloid Leukemia with Solitary Extramedullary Bone Deposit Open
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, characterized by a hematopoietic stem cell carrying BCR-ABLl fusion protein. Common sites of extramedullary deposits in CML are lymph nodes, bones, and central nervous system…
View article: Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India – response to Gupta <i>et al</i>
Treatment rates of paediatric acute myeloid leukaemia: a view from three tertiary centres in India – response to Gupta <i>et al</i> Open
We have noted the observations and data presented by Gupta et al regarding the treatment rates of paediatric acute myeloid leukaemia (AML) patients in India. The discussion section of our paper carefully qualified the limitations of extrap…
View article: RNA Expression of Genes Involved in Cytarabine Metabolism and Transport Predicts Cytarabine Response in Acute Myeloid Leukemia
RNA Expression of Genes Involved in Cytarabine Metabolism and Transport Predicts Cytarabine Response in Acute Myeloid Leukemia Open
This study highlights the importance of evaluating expression of candidate Ara-C metabolizing genes in predicting ex vivo drug response as well as treatment outcome. RI could be a predictor of ex vivo Ara-C response irrespective of cytogen…
View article: Acute myeloid leukaemia: challenges and real world data from India
Acute myeloid leukaemia: challenges and real world data from India Open
Summary The management of acute myeloid leukaemia ( AML ) in India remains a challenge. In a two‐year prospective study at our centre there were 380 newly diagnosed AML (excluding acute promyelocytic leukaemia, AML ‐M3) patients. The media…