Cher Sha
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View article: The hematopoietic stem cell MYB enhancer is essential and recurrently amplified during T-cell leukemogenesis
The hematopoietic stem cell MYB enhancer is essential and recurrently amplified during T-cell leukemogenesis Open
There is an urgent need to find targeted agents for T-cell acute lymphoblastic leukemia (T-ALL). NOTCH1 is the most frequently mutated oncogene in T-ALL, but clinical trials showed that pan-Notch inhibitors caused dose-limiting toxicities.…
View article: Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation
Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation Open
View article: Combinatorial ETS1-Dependent Control of Oncogenic NOTCH1 Enhancers in T-cell Leukemia
Combinatorial ETS1-Dependent Control of Oncogenic NOTCH1 Enhancers in T-cell Leukemia Open
Notch activation is highly prevalent among cancers, in particular T-cell acute lymphoblastic leukemia (T-ALL). However, the use of pan-Notch inhibitors to treat cancers has been hampered by adverse effects, particularly intestinal toxiciti…
View article: Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development Open
Key Points Notch1 cofactor Zmiz1 induces a subset of Notch target genes and drives pre–T-cell proliferation during normal and stress thymopoiesis. Disrupting the Zmiz1-Notch1 protein-protein interaction impairs Myc induction, pre–T-cell ex…