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View article: Pervasive Intestinal Carriage with Multiple Species of Extended Spectrum Cephalosporin-Resistant Enterobacterales in Children Admitted for Severe Acute Malnutrition at a Tertiary Hospital in Malawi
Pervasive Intestinal Carriage with Multiple Species of Extended Spectrum Cephalosporin-Resistant Enterobacterales in Children Admitted for Severe Acute Malnutrition at a Tertiary Hospital in Malawi Open
Using culture-based screening of stool specimens, 80.3% of 188 children hospitalized for severe acute malnutrition in Malawi carried extended spectrum cephalosporin resistant Enterobacterales (ESCR-E) at admission. 38.3% of children were c…
View article: Klinefelter Mosaicism 46, XX/47, XXY with Ovotestis- DSD
Klinefelter Mosaicism 46, XX/47, XXY with Ovotestis- DSD Open
Klinefelter syndrome is a relatively common chromosomal condition affecting approximately 1 in 500-1,000 males. 46, XX /47 XXY Klinefelter Syndrome mosaicism is rare enough, resulting in a few cases described in literature. Variable phenot…
View article: Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities
Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa: Challenges and Opportunities Open
PURPOSE Prostate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research…
View article: Overview of Adrenals Tumors in Dakar Hospitals
Overview of Adrenals Tumors in Dakar Hospitals Open
Introduction: Adrenal tumours (AT) are commonly encountered in clinical practice. For any patient presenting an adrenal mass, there are two crucial points to consider: is the adrenal mass malignant and is it hormonally active? The objectiv…
View article: Genomic of Prostate Cancer in Senegal: Perspectives in the Era of Genome Wide Association Studies
Genomic of Prostate Cancer in Senegal: Perspectives in the Era of Genome Wide Association Studies Open
Introduction: Prostate cancer is the second most commonly diagnosed cancer in men from Sub Saharan Africa including Senegal and a major cancer related cause of death. Carcinogenesis involves both environmental and genetic factors. The aim …
View article: Utility of formalin-fixed, paraffin-embedded prostate biospecimens from low-resource settings for use in next-generation sequencing studies in African-descent populations
Utility of formalin-fixed, paraffin-embedded prostate biospecimens from low-resource settings for use in next-generation sequencing studies in African-descent populations Open
Background Men of African ancestry experience higher burden from prostate cancer compared to men of other ancestral backgrounds. Limitations in the availability of high-quality biospecimens hinder the inclusion of this population in geneti…
View article: Lesions Superimposed by Traditional Medicine on Renal Biopsies in Senegal
Lesions Superimposed by Traditional Medicine on Renal Biopsies in Senegal Open
Traditional African medicine products are responsible for kidney damage that baffles both nephrologists and pathologists. Renal biopsies reveal acute or chronic inflammatory changes that cannot be explained by the progressive stage of the …
View article: Chronic viral hepatitis, <scp>HIV</scp> infection and <scp>Non‐Hodgkin</scp> lymphomas in West Africa, a case‐control study
Chronic viral hepatitis, <span>HIV</span> infection and <span>Non‐Hodgkin</span> lymphomas in West Africa, a case‐control study Open
Non‐Hodgkin lymphomas (NHL) are underestimated causes of cancer in West Africa where chronic viral hepatitis and HIV are endemic. While the association with HIV infection has already been characterized, limited information is available on …
View article: Epidemiological and Diagnostic Aspects of Bladder Bilharziomas in the Urology Department of Idrissa Pouye General Hospital (HOGIP)
Epidemiological and Diagnostic Aspects of Bladder Bilharziomas in the Urology Department of Idrissa Pouye General Hospital (HOGIP) Open
Objective. The aim of our study is to assess the diagnostic aspects of bladder bilharzioma in the Urology Department of Idrissa Pouye General Hospital (Senegal). Materials and Methods. It is a descriptive study from January 2013 to Decembe…
View article: Epidemiological and Cytological Profile of Breast Masses with Satellite Lymphadenopathies: About 422 Cases, Collected in Dakar, Senegal
Epidemiological and Cytological Profile of Breast Masses with Satellite Lymphadenopathies: About 422 Cases, Collected in Dakar, Senegal Open
Introduction: Breast masses with satellite adenopathies are a frequent reason for consultation, of various etiologies. Breast cancer, a major public health problem, remains the main obsession of the practitioner.
Goals: Describe the epide…
View article: Primary squamous cell carcinoma of the kidney in southern Senegal (Ziguinchor): case report and review of the literature
Primary squamous cell carcinoma of the kidney in southern Senegal (Ziguinchor): case report and review of the literature Open
The kidney's primary squamous cell carcinoma is a rare tumor, representing 0.5-0.8% of malignant renal tumors and 4% of upper urinary tract tumors. This pathology often occurs after a long past history of renal lithiasis and repeated untre…
View article: Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts
Is Schistosomiasis a Risk Factor for Bladder Cancer? Evidence-Based Facts Open
Background . Globally, approximately 20% of malignancy are caused by infection. Schistosoma infection is a major cause of bladder in most part of Africa. In 2018 alone, there were approximately 549,393 new cases and 199,922 deaths from bla…
View article: Kaposi’s Disease (KS) in a Senegalese Child Living with HIV
Kaposi’s Disease (KS) in a Senegalese Child Living with HIV Open
Kaposi’s Disease or Kaposi’s Sarcoma (SK ) is a multifocal malignant proliferation induced by viral growth factors, including interleukin 6 of human herpes virus type 8 (HHV8). We describe four forms of this disease who poses a real public…
View article: Histopathologic Profile of Miscarriages during First Trimester of Pregnancy in Teaching Hospital of Grand Yoff in Dakar (Senegal)
Histopathologic Profile of Miscarriages during First Trimester of Pregnancy in Teaching Hospital of Grand Yoff in Dakar (Senegal) Open
Background: Mainly for economic reasons, histopathologic analysis is not a systematic practice in medical structures in Senegal, and the utility of this exam is being questioned by many authors. The purpose of this paper is to report the r…
View article: Matrixmetalloproteinase-9 Genetic Variation with Cataract, Glaucoma and Retinoblastoma in a Senegalese Population
Matrixmetalloproteinase-9 Genetic Variation with Cataract, Glaucoma and Retinoblastoma in a Senegalese Population Open
The Matrix metalloproteinase-9 is involved in several pathologies. Its strong presence in ocular pathologies explains our interest for its genetic variation in cataract, glaucoma and retinoblastoma in Senegal. MMP9 is highly polymorphic wi…
View article: Retinoblastoma in children: a case series from Senegal
Retinoblastoma in children: a case series from Senegal Open
Retinoblastoma is the most common tumor of the eye in Senegalese children. Diagnosis occurs often at a late stage, when enucleation is unavoidable. In this report, we describe all recorded cases occurring in Senegal over a 10-year period (…
View article: Renal Biopsy in the Elderly in Senegal: Indications and Outcomes
Renal Biopsy in the Elderly in Senegal: Indications and Outcomes Open
Introduction:Renal biopsy (RB) is poorly performed in sub-Saharan Africa.It is even less practiced in the elderly.The objective of this study was to determine the indications of RB in the elderly and to describe the histopathological aspec…
View article: Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate
Development, Evaluation, and Implementation of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate Open
Purpose Cancer of the prostate (CaP) is the leading cancer among men in sub-Saharan Africa (SSA). A substantial proportion of these men with CaP are diagnosed at late (usually incurable) stages, yet little is known about the etiology of Ca…
View article: HPV Genotypes of Senegalese Women Attending Radiotherapy
HPV Genotypes of Senegalese Women Attending Radiotherapy Open
Objectives: This work was carried out in order to determine the profile of different HPV genotypes in a population of women attending radiotherapy (RT). Material and Methods: This is a retrospective study. Sixty paraffin blocks were chosen…
View article: Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases
Management of Pheochromocytoma in Dakar: Diagnostic and Therapeutic Advances throughout 16 Cases Open
Introduction: Management of pheochromocytoma faces different challenges leading to misdiagnosis and therapeutic delay in developing countries. The aim of our study was to evaluate the diagnostic and therapeutic features as well as the evol…