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View article: Effectiveness of amoxicillin and amoxicillin-clavulanate for the treatment of community-acquired pneumonia in adults and children: systematic review and meta-analysis
Effectiveness of amoxicillin and amoxicillin-clavulanate for the treatment of community-acquired pneumonia in adults and children: systematic review and meta-analysis Open
Introduction Community-acquired pneumonia (CAP) is a key contributor to the global burden of morbidity and mortality, and it drives large volumes of antibiotic use. Despite widespread recommendation to use amoxicillin for treatment, there …
View article: Two decades of bacteraemia in Norway: increasing incidence and shifts in microbial epidemiology, 2005-2024
Two decades of bacteraemia in Norway: increasing incidence and shifts in microbial epidemiology, 2005-2024 Open
This study aimed to describe temporal changes in the incidence and microbial composition of bacteraemia in Norway from 2005 to 2024. Using national surveillance data from all microbiology laboratories, combined with contextual indicators s…
View article: Epidemiology and excess mortality of antimicrobial resistance in bacteraemias among cancer patients: a cohort study using routinely collected health data from regional hospital trusts in Oxford and Oslo, 2008–2018
Epidemiology and excess mortality of antimicrobial resistance in bacteraemias among cancer patients: a cohort study using routinely collected health data from regional hospital trusts in Oxford and Oslo, 2008–2018 Open
Objectives We investigated the epidemiology and impact on mortality of antimicrobial resistance (AMR) in cancer patients with bacteraemia at Oxford University Hospitals (OxUH), UK, and Oslo University Hospital (OsUH), Norway, during 2008–2…
View article: Situational analysis of antibiotic prescriptions in Kenyan neonatal units for antimicrobial stewardship: a retrospective longitudinal study
Situational analysis of antibiotic prescriptions in Kenyan neonatal units for antimicrobial stewardship: a retrospective longitudinal study Open
This work was funded by the Wellcome Trust.
View article: Resampled Mutual Information for Clustering and Community Detection
Resampled Mutual Information for Clustering and Community Detection Open
We introduce resampled mutual information (ResMI), a novel measure of clustering similarity that combines insights from information theoretic and pair counting approaches to clustering and community detection. Similar to chance-corrected m…
View article: Epidemiology and excess mortality of antimicrobial resistance in bacteraemias among cancer patients: a cohort study using routinely collected health data from regional hospital trusts in Oxford and Oslo, 2008-2018
Epidemiology and excess mortality of antimicrobial resistance in bacteraemias among cancer patients: a cohort study using routinely collected health data from regional hospital trusts in Oxford and Oslo, 2008-2018 Open
Objectives: We investigated the epidemiology and impact on mortality of antimicrobial resistance (AMR) in cancer patients with bacteraemia at Oxford University Hospitals (OxUH), UK, and Oslo University Hospital (OsUH), Norway, during 2008-…
View article: Automating the Generation of Notifiable Bacterial Disease Reports: Proof-of-Concept Study and Implementation in Six Hospitals in Thailand
Automating the Generation of Notifiable Bacterial Disease Reports: Proof-of-Concept Study and Implementation in Six Hospitals in Thailand Open
Information on notifiable bacterial diseases (NBD) in low- and middle-income countries (LMICs) is frequently incomplete. We developed the AutoMated tool for the Antimicrobial resistance Surveillance System plus (AMASSplus), which can suppo…
View article: Frequency and mortality rate following antimicrobial-resistant bloodstream infections in tertiary-care hospitals compared with secondary-care hospitals
Frequency and mortality rate following antimicrobial-resistant bloodstream infections in tertiary-care hospitals compared with secondary-care hospitals Open
There are few studies comparing proportion, frequency, mortality and mortality rate following antimicrobial-resistant (AMR) infections between tertiary-care hospitals (TCHs) and secondary-care hospitals (SCHs) in low and middle-income coun…
View article: Is an active hospital microbiology laboratory cost-effective in a resource-limited setting? - a case study from Timor-Leste
Is an active hospital microbiology laboratory cost-effective in a resource-limited setting? - a case study from Timor-Leste Open
Maintaining an active hospital microbiology laboratory allows definitive antibiotic treatment for bacterial infections to be given in a timely manner. This would be expected to improve patient outcomes and shorten length of hospital stay. …
View article: Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis
Implications of reducing antibiotic treatment duration for antimicrobial resistance in hospital settings: A modelling study and meta-analysis Open
Background Reducing antibiotic treatment duration is a key component of hospital antibiotic stewardship interventions. However, its effectiveness in reducing antimicrobial resistance is uncertain and a clear theoretical rationale for the a…
View article: Higher Frequency and Mortality Rate of Antimicrobial-resistant Bloodstream Infections in Tertiary-care Hospitals Compared with Secondary-care Hospitals in Thailand
Higher Frequency and Mortality Rate of Antimicrobial-resistant Bloodstream Infections in Tertiary-care Hospitals Compared with Secondary-care Hospitals in Thailand Open
There are few studies comparing proportion, frequency, mortality and mortality rate of antimicrobial-resistant (AMR) bacterial infections between tertiary-care hospitals (TCHs) and secondary-care hospitals (SCHs) in low and middle-income c…
View article: AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0)
AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0) Open
Version 2.0Release date: 15th September 2023This version fixes a code issue present in the release from 16th November 2022, which was causing a failure to generate the complete Annex B on page 42.This version fixes a typo in the R code of …
View article: Impact of a multimodal hand hygiene improvement intervention in a 1000-bed hospital in Thailand: a stepped wedge cluster randomized controlled trial
Impact of a multimodal hand hygiene improvement intervention in a 1000-bed hospital in Thailand: a stepped wedge cluster randomized controlled trial Open
Background Good hand hygiene compliance amongst healthcare workers is critical for patient safety and plays a central role in preventing healthcare-associated infections. The World Health Organization (WHO) recommends a multimodal strategy…
View article: Excess Mortality Attributable to Hospital-Acquired Antimicrobial-Resistant Infections: A 2-Year Prospective Surveillance Study in Northeast Thailand
Excess Mortality Attributable to Hospital-Acquired Antimicrobial-Resistant Infections: A 2-Year Prospective Surveillance Study in Northeast Thailand Open
Background Quantifying the excess mortality attributable to antimicrobial-resistant (AMR) bacterial infections is important for assessing the potential benefit of preventive interventions and for prioritization of resources. However, there…
View article: Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis Open
Bill & Melinda Gates Foundation, Wellcome Trust, and Department of Health and Social Care using UK aid funding managed by the Fleming Fund.
View article: AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0)
AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0) Open
Version 2.0 Release date: 16th November 2022 This version fixes a typo in the R code of the release 16th August 2022 that caused inaccurate estimations of the proportion of patients with non-susceptible isolates against levofloxacin and c…
View article: AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0)
AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0) Open
Version 2.0 Release date: 16th November 2022 This version fixes a typo in the R code of the release 16th August 2022 that caused inaccurate estimations of the proportion of patients with non-susceptible isolates against levofloxacin and c…
View article: AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0)
AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0) Open
Version 2.0 Release date: 16th August 2022 This version fixes a typo in the R code of the release 16th May 2022 that cause inaccurate estimations of the proportion of non-susceptible isolates against levofloxacin and carbapenem drugs. T…
View article: The effect of hand hygiene frequency on reducing acute respiratory infections in the community: a meta-analysis
The effect of hand hygiene frequency on reducing acute respiratory infections in the community: a meta-analysis Open
Hand hygiene is a simple, low-cost intervention that may lead to substantial population-level effects in suppressing acute respiratory infection epidemics. However, quantification of the efficacy of hand hygiene on respiratory infection in…
View article: AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0)
AutoMated tool for Antimicrobial resistance Surveillance System version 2.0 (AMASSv2.0) Open
Version 2.0 Release date: 16th May 2022 The current version of the AMASS application provides additional reports on notifiable bacterial diseases in Annex A and on data indicators (including proportion of contaminants and discordant AST …
View article: Effect of Delays in Concordant Antibiotic Treatment on Mortality in Patients With Hospital-Acquired <i>Acinetobacter</i> Species Bacteremia: Emulating a Target Randomized Trial With a 13-Year Retrospective Cohort
Effect of Delays in Concordant Antibiotic Treatment on Mortality in Patients With Hospital-Acquired <i>Acinetobacter</i> Species Bacteremia: Emulating a Target Randomized Trial With a 13-Year Retrospective Cohort Open
Delays in treating bacteremias with antibiotics to which the causative organism is susceptible are expected to adversely affect patient outcomes. Quantifying the impact of such delays to concordant treatment is important for decision-makin…