Cheryl A. Janson
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View article: Investigating the Roles of Active Site Residues in <i>Mycobacterium tuberculosis</i> Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents
Investigating the Roles of Active Site Residues in <i>Mycobacterium tuberculosis</i> Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents Open
Mycobacterium tuberculosis drug resistance is emerging and new drug targets are needed. Tryptophan biosynthesis is necessary for M. tuberculosis replication and virulence. Indole-3-glycerol phosphate synthase (IGPS) catalyzes a step in M. …
View article: Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate
Crystal structure of dihydrofolate reductase from the filarial nematode W. bancrofti in complex with NADPH and folate Open
Lymphatic filariasis is a debilitating illness with an estimated 50 million cases as of 2018. The majority of cases are caused by the parasitic worm W . bancrofti and additional cases by the worms B . malayi and B . timori . Dihydrofolate …
View article: Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti
Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti Open
Filariasis is a tropical disease caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. Known inhibitors of dihydrofolate reductase (DHFR) have been previously shown to kill Brugia malayi nematodes and to inhibit Brugia …