Cheryl Carcel
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View article: Associations of blood pressure parameters with cognitive decline and dementia: a systematic review of reviews
Associations of blood pressure parameters with cognitive decline and dementia: a systematic review of reviews Open
Background Evidence syntheses on the associations between blood pressure (BP) parameters and cognitive decline and/or dementia have taken different methodological approaches and targeted different BP parameters and outcomes. The aim of thi…
View article: Blood pressure lowering for prevention of episodic migraine: results of a pilot randomized, placebo-controlled trial of combination blood pressure lowering medication with propranolol
Blood pressure lowering for prevention of episodic migraine: results of a pilot randomized, placebo-controlled trial of combination blood pressure lowering medication with propranolol Open
Background Beta blockers are effective in migraine prevention. Low-dose combination therapy of blood pressure lowering is likely to lower blood pressure more than a beta-blocker, but there are no data on comparative efficacy of these treat…
View article: Statistical analysis plan for the STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER) study: a randomised, open label, controlled trial in subjects with persistent neurological symptoms after COVID-19 infection
Statistical analysis plan for the STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER) study: a randomised, open label, controlled trial in subjects with persistent neurological symptoms after COVID-19 infection Open
We outline the statistical análysis plan (SAP) for the STatin TReatment for COVID-19 to Optimise NeuroloGical (STRONGER) study. STRONGER is an international, investigator-initiated and conducted, multicentre, prospective, randomised, open …
View article: Health and economic benefits of improving pre‐hospital identification of stroke in Australian women: a modelling study
Health and economic benefits of improving pre‐hospital identification of stroke in Australian women: a modelling study Open
Objective To estimate the long term gains in life years and quality‐adjusted life years (QALYs) and the cost savings that could be achieved if ischaemic stroke was identified in women with the same level of accuracy received by men, versus…
View article: STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection
STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection Open
Introduction Increasing awareness of the high frequency, wide spectrum and disabling nature of symptoms that can persist following COVID-19 infection has prompted the investigation of management strategies. Our study aims to determine the …
View article: Sex Differences in the Participation in Secondary Prevention Stroke Studies
Sex Differences in the Participation in Secondary Prevention Stroke Studies Open
Background Women show higher age‐standardized mortality rates for ischemic stroke. Nevertheless, women are underrepresented in secondary stroke prevention trials. Our analysis investigated contributors to reduced study participation among …
View article: Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations
Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations Open
Revising public health policy based on new data does not happen automatically. This is acutely relevant to the now undeniable evidence that many diseases develop differently between the sexes and may also be affected by gender. Current hea…
View article: Twenty‐Four‐Hour Post‐Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study
Twenty‐Four‐Hour Post‐Thrombolysis NIHSS Score As the Strongest Prognostic Predictor After Acute Ischemic Stroke: ENCHANTED Study Open
Background This study was conducted to determine optimal predictive ability of National Institutes of Health Stroke Scale (NIHSS) measurements at baseline, 24 hours, and change from baseline to 24 hours after thrombolysis on functional rec…
View article: Policies on the collection, analysis, and reporting of sex and gender in Australian health and medical research: a mixed methods study
Policies on the collection, analysis, and reporting of sex and gender in Australian health and medical research: a mixed methods study Open
Objective To explore the policies of key organisations in Australian health and medical research on defining, collecting, analysing, and reporting data on sex and gender, and to identify barriers to and facilitators of developing and imple…
View article: Should women have lower blood pressure targets than men? Sex differences in blood pressure and cardiovascular disease in the UK Biobank
Should women have lower blood pressure targets than men? Sex differences in blood pressure and cardiovascular disease in the UK Biobank Open
Background Recent studies show that the risk of cardiovascular disease (CVD) increases from a lower nadir of systolic blood pressure (SBP) in women than men, and increases thereafter at a greater rate. This has led to a suggestion that sex…
View article: Randomised controlled decentralised feasibility trial of a fixed low-dose combination antihypertensive drug strategy to attenuate cognitive decline in high-risk adults
Randomised controlled decentralised feasibility trial of a fixed low-dose combination antihypertensive drug strategy to attenuate cognitive decline in high-risk adults Open
Objectives The Action To promote brain HEalth iN Adults study aimed to determine the feasibility and applicability of recruitment using home blood pressure (BP) monitoring, routine blood biochemistry and videoconference measures of cogniti…
View article: Theory of change for addressing sex and gender bias, invisibility and exclusion in Australian health and medical research, policy and practice
Theory of change for addressing sex and gender bias, invisibility and exclusion in Australian health and medical research, policy and practice Open
Sex and gender are inadequately considered in health and medical research, policy and practice, leading to preventable disparities in health and wellbeing. Several global institutions, journals, and funding bodies have developed policies a…
View article: Neglecting sex and gender in research is a public-health risk
Neglecting sex and gender in research is a public-health risk Open
View article: Influence of Socioeconomic Status on Functional Outcomes After Stroke: A Systematic Review and Meta‐Analysis
Influence of Socioeconomic Status on Functional Outcomes After Stroke: A Systematic Review and Meta‐Analysis Open
Background This review aimed to quantify the impact of socioeconomic status on functional outcomes from stroke and identify the socioeconomic status indicators that exhibit the highest magnitude of association. Methods and Results We perfo…
View article: Theory of Change for addressing sex and gender bias, invisibility and exclusion in health and medical research, policy, and practice
Theory of Change for addressing sex and gender bias, invisibility and exclusion in health and medical research, policy, and practice Open
Background:Sex and gender are inadequately considered in health and medical research, policy and practice, leading to preventable disparities in health and wellbeing. Several global institutions, journals, and funding bodies have developed…
View article: Sex differences in risk factors for incident peripheral artery disease hospitalisation or death: Cohort study of UK Biobank participants
Sex differences in risk factors for incident peripheral artery disease hospitalisation or death: Cohort study of UK Biobank participants Open
Background Women with peripheral artery disease (PAD) often have atypical symptoms, late hospital presentations, and worse prognosis. Risk factor identification and management are important. We assessed sex differences in associations of r…
View article: Influence of socioeconomic status on functional outcomes after stroke: a systematic review and meta-analysis
Influence of socioeconomic status on functional outcomes after stroke: a systematic review and meta-analysis Open
Background Despite advances in stroke treatment and rehabilitation, socioeconomic factors have an important impact on recovery from stroke. This review aimed to quantify the impact of socioeconomic status (SES) on functional outcomes from …
View article: The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis
The effect of blood pressure lowering medications on the prevention of episodic migraine: A systematic review and meta-analysis Open
Background Currently, only a few specific blood pressure-lowering medications are recommended for migraine prevention. Whether benefits extend to other classes or drugs is uncertain. Methods Embase, MEDLINE, and the Cochrane Central Regist…
View article: Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials
Sex differences in pain expressed by patients across diverse disease states: individual patient data meta-analysis of 33,957 participants in 10 randomized controlled trials Open
The experience of pain is determined by many factors and has a significant impact on quality of life. This study aimed to determine sex differences in pain prevalence and intensity reported by participants with diverse disease states in se…
View article: Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial
Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial Open
View article: Women's representation in clinical trials of patients with chronic kidney disease
Women's representation in clinical trials of patients with chronic kidney disease Open
Background Sex and gender differences in chronic kidney disease (CKD), including epidemiology and response to treatment, remain poorly understood. This study aimed to investigate how women are represented in CKD clinical trials and whether…
View article: Sex differences in the utilization and outcomes of endovascular treatment after acute ischemic stroke: A systematic review and meta-analysis
Sex differences in the utilization and outcomes of endovascular treatment after acute ischemic stroke: A systematic review and meta-analysis Open
Background Studies of sex differences in the use and outcomes of endovascular treatment (EVT) for acute ischemic stroke report inconsistent results Methods We systematically searched PubMed and Embase databases for studies examining sex-sp…
View article: Sex and gender reporting in Australian health and medical research publications
Sex and gender reporting in Australian health and medical research publications Open
Reporting and analysis of sex and gender data in health research in Australian medical journals requires improvement, for better health for all.
View article: Gender diversity of clinical practice guideline panels in Australia: important opportunities for progress
Gender diversity of clinical practice guideline panels in Australia: important opportunities for progress Open
Editorialsof questions of particular concern to women and men, leading to more focused recommendations and ultimately better health outcomes for all.
View article: S-16-1: RESISTANT HYPERTENISION: CLINICAL CHARACTERISTICS AND BLOOD PRESSURE CONTROL
S-16-1: RESISTANT HYPERTENISION: CLINICAL CHARACTERISTICS AND BLOOD PRESSURE CONTROL Open
Objectives: We quantified the characteristics of patients with treatment resistant hypertension (TRH) in a large multi-country sample of specialist tertiary centres and estimated incidence and prevalence in participating regions. Methods: …
View article: Associations of Combined Healthy Lifestyles with the Risk of Cardiovascular Disease: A Prospective Cohort Study of UK Biobank
Associations of Combined Healthy Lifestyles with the Risk of Cardiovascular Disease: A Prospective Cohort Study of UK Biobank Open
View article: Differences in the pre‐hospital management of women and men with stroke by emergency medical services in New South Wales
Differences in the pre‐hospital management of women and men with stroke by emergency medical services in New South Wales Open
View article: Corrigendum: Sex-differences in oral anticoagulant-related intracerebral hemorrhage
Corrigendum: Sex-differences in oral anticoagulant-related intracerebral hemorrhage Open
[This corrects the article DOI: 10.3389/fneur.2022.832903.].
View article: Antithrombotics prescription and adherence among stroke survivors: A systematic review and meta‐analysis
Antithrombotics prescription and adherence among stroke survivors: A systematic review and meta‐analysis Open
Objectives We aimed to investigate the prescription of antithrombotic drugs (including anticoagulants and antiplatelets) and medication adherence after stroke. Methods We performed a systematic literature search across MEDLINE and Embase, …
View article: Dementia clinical trials over the past decade: are women fairly represented?
Dementia clinical trials over the past decade: are women fairly represented? Open
Background Lack of progress in finding disease-modifying treatments for dementia may be due to heterogeneity in treatment effects among subgroups, such as by sex. Therefore, we investigated the characteristics of dementia trials completed …