Cheryl D. Stimpson
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View article: Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation
Endogenously generated Dutch-type Aβ nonfibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation Open
APP E693Q transgenic mice develop aging-related learning deficits and accumulate endogenously generated nonfibrillar aggregates of Aβ (NFA-Aβ) and APP α-carboxy terminal fragments. The APP E693Q mutation disrupts amyloid fibril formation, …
View article: The role of microglia in neuronal and cognitive function during high altitude acclimatization
The role of microglia in neuronal and cognitive function during high altitude acclimatization Open
Due to their interactions with the neurovasculature, microglia are implicated in maladaptive responses to hypobaric hypoxia at high altitude (HA). To explore these interactions at HA, pharmacological depletion of microglia with the colony-…
View article: Low-Dose Brain Radiation: Lowering hyperphosphorylated-Tau without Increasing DNA Damage or Oncogenic Activation
Low-Dose Brain Radiation: Lowering hyperphosphorylated-Tau without Increasing DNA Damage or Oncogenic Activation Open
Brain radiation has been medically used to alter the metabolism of cancerous cells and induce their elimination. Rarely, though, brain radiation has been used to interfere with the pathomechanisms of non-cancerous brain disorders, especial…
View article: Double Blast Wave Primary Effect on Synaptic, Glymphatic, Myelin, Neuronal and Neurovascular Markers
Double Blast Wave Primary Effect on Synaptic, Glymphatic, Myelin, Neuronal and Neurovascular Markers Open
Explosive blasts are associated with neurological consequences as a result of blast waves impact on the brain. Yet, the neuropathologic and molecular consequences due to blast waves vs. blunt-TBI are not fully understood. An explosive-driv…
View article: The Nucleus Accumbens and Ventral Pallidum Exhibit Greater Dopaminergic Innervation in Humans Compared to Other Primates
The Nucleus Accumbens and Ventral Pallidum Exhibit Greater Dopaminergic Innervation in Humans Compared to Other Primates Open
Recent evidence suggests that increased dopaminergic signaling within the dorsal striatum played a central role in the evolution of the human brain. This increase has been linked to human pro-sociality and language in what has been describ…
View article: Invariant Synapse Density and Neuronal Connectivity Scaling in Primate Neocortical Evolution
Invariant Synapse Density and Neuronal Connectivity Scaling in Primate Neocortical Evolution Open
Synapses are involved in the communication of information from one neuron to another. However, a systematic analysis of synapse density in the neocortex from a diversity of species is lacking, limiting what can be understood about the evol…