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View article: Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases
Association Between Nutritional Status and Survival in Patients Requiring Treatment for Spinal Metastases Open
BACKGROUND AND OBJECTIVES: The Patient-Generated Subjective Global Assessment (PG-SGA) is a standardized tool for assessing malnutrition in patients with cancer. The primary aim of this study was to assess the impact of preoperative nutrit…
View article: Correction to: Stereotactic radiosurgery for patients with extensive brain metastases across the disease course
Correction to: Stereotactic radiosurgery for patients with extensive brain metastases across the disease course Open
View article: Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells
Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells Open
Chimeric antigen receptor (CAR)-T cell therapies that broadly target B cells can achieve complete remission in severe systemic lupus erythematosus (SLE) but carry an increased risk of infection and cytokine-related toxicities that limit th…
View article: Data from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Data from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Patients with radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an invasive and dange…
View article: Supplementary Tables S1-S19 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Supplementary Tables S1-S19 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Supplementary Table S1: Cohorts for CSF-BAM components. Supplementary Table S2A: SafeBSeqS primer sequences. Supplementary Table S2B: SafeTseqS primer sequences. Supplementary Table S2C: Aneuploidy analysis primer sequences. Supplementary …
View article: Supplementary Figures S1-S9 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Supplementary Figures S1-S9 from Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Supplementary Figure S1. SafeBSeqS amplification. Supplementary Figure S2. SafeTSeqS amplification. Supplementary Figure S3. Aneuploidy reproducibility from two independent aliquots and libraries. Supplementary Figure S4. Metrics for targe…
View article: Author Correction: Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care
Author Correction: Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care Open
View article: OS11.5.A PREOPERATIVE ASSESSMENT OF TUMOR ELOQUENCE AND RESECTABILITY: AN INTERNATIONAL SURVEY
OS11.5.A PREOPERATIVE ASSESSMENT OF TUMOR ELOQUENCE AND RESECTABILITY: AN INTERNATIONAL SURVEY Open
BACKGROUND Tumor location and its proximity to eloquent brain areas are key factors in glioma surgery decision-making. However, the absence of a consensus definition for eloquent brain areas leads to variability in surgical decision-making…
View article: Dual checkpoint blockade of glioblastoma with Anti-PD-1 and Anti-LAG-3 promotes expansion of tumor-reactive T cell clones along a unique pathway of differentiation
Dual checkpoint blockade of glioblastoma with Anti-PD-1 and Anti-LAG-3 promotes expansion of tumor-reactive T cell clones along a unique pathway of differentiation Open
IDH-wildtype grade IV glioblastoma is the most aggressive adult primary brain tumor and remains refractory to anti-PD-1 monotherapy despite evidence of limited tumor-specific T cell induction. To determine the impact of immune checkpoint i…
View article: Supplementary Tables S1 to S6 from Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA
Supplementary Tables S1 to S6 from Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA Open
Table S1: Genes and regions interrogated by the targeted mutation panel, assuming 75bp amplicon size. Table S2: Mutations detected with targeted driver gene panel in Early and Very Early plasma samples. Table S3: Clinical characteristics o…
View article: Data from Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA
Data from Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA Open
To explore how early cancers can be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities study, including 26 participants diagnosed with cancer…
View article: Impact of preoperative medical management on postoperative outcomes after index percutaneous rhizotomy for trigeminal neuralgia
Impact of preoperative medical management on postoperative outcomes after index percutaneous rhizotomy for trigeminal neuralgia Open
OBJECTIVE Initial medical management fails in nearly half of patients with trigeminal neuralgia (TN), and patients will seek surgical management with either rhizotomy or microvascular decompression. The impact of preoperative medical manag…
View article: The association of frailty with worse pain outcomes in older patients with trigeminal neuralgia treated using primary percutaneous glycerin rhizotomy
The association of frailty with worse pain outcomes in older patients with trigeminal neuralgia treated using primary percutaneous glycerin rhizotomy Open
OBJECTIVE Trigeminal neuralgia (TN) is a neurological disorder that typically manifests as excruciating orofacial pain along the branches of the trigeminal nerve. Percutaneous treatments for TN have been shown to provide short-term pain re…
View article: A sensitive and specific non-invasive urine biomarker panel for prostate cancer detection
A sensitive and specific non-invasive urine biomarker panel for prostate cancer detection Open
This study was supported by the International Prostate Cancer Foundation, JHU SKCCC (grant number P30CA006973), and Bankhead-Coley Cancer Research Program (grant number 24B16) to R. J. Perera and by the Maryland Innovation Initiative Grant…
View article: Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM
Detection of Human Brain Cancers using Genomic and Immune Cell Characterization of Cerebrospinal Fluid through CSF-BAM Open
Patients with radiographically detectable lesions in their brain or other symptoms compatible with brain tumors pose challenges for diagnosis. The only definitive way to diagnose such patients is through brain biopsy, an invasive and dange…
View article: Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases
Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases Open
Multiple case-controlled studies have shown that analyzing fragmentation patterns in plasma cell-free DNA (cfDNA) can distinguish individuals with cancer from healthy controls. However, there have been few studies that investigate various …
View article: Minimizing and quantifying uncertainty in AI-informed decisions: Applications in medicine
Minimizing and quantifying uncertainty in AI-informed decisions: Applications in medicine Open
AI is now a cornerstone of modern dataset analysis. In many real world applications, practitioners are concerned with controlling specific kinds of errors, rather than minimizing the overall number of errors. For example, biomedical screen…
View article: Mechanistic insights and basis for real-time monitoring and closed-loop feedback control in sonodynamic therapy for glioblastoma
Mechanistic insights and basis for real-time monitoring and closed-loop feedback control in sonodynamic therapy for glioblastoma Open
Sonodynamic therapy (SDT) involves the administration of otherwise inactive agents that can be activated by acoustic energy ('sonosensitizers') to impart therapeutic effects. SDT is a treatment of significant clinical interest in glioblast…
View article: 19 SURVIVAL AND RECURRENCE OUTCOMES FOR PRIMARY MENINGEAL MELANOCYTIC NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM IN A MULTICENTER COHORT
19 SURVIVAL AND RECURRENCE OUTCOMES FOR PRIMARY MENINGEAL MELANOCYTIC NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM IN A MULTICENTER COHORT Open
BACKGROUND Primary melanocytic neoplasms of the central nervous system (PMN-CNS) are rare lesions of variable aggressiveness originating from leptomeningeal melanocytes. They present as either circumscribed or diffuse lesions within the CN…
View article: RDTA-15 SAFETY AND EFFICACY OF STEREOTACTIC RADIOSURGERY FOR 15 OR MORE BRAIN METASTASES
RDTA-15 SAFETY AND EFFICACY OF STEREOTACTIC RADIOSURGERY FOR 15 OR MORE BRAIN METASTASES Open
PURPOSE Stereotactic radiosurgery (SRS) is a mainstay treatment for patients with limited brain metastases (BM). As advancements in systemic therapies have prolonged survival in metastatic disease, evaluating the role of SRS in patients wi…
View article: A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis Open
View article: Leveraging pretrained vision transformers for automated cancer diagnosis in optical coherence tomography images
Leveraging pretrained vision transformers for automated cancer diagnosis in optical coherence tomography images Open
This study presents an approach to brain cancer detection based on optical coherence tomography (OCT) images and advanced machine learning techniques. The research addresses the critical need for accurate, real-time differentiation between…
View article: Evaluation of Adverse Events and the Impact on Health-Related Outcomes in Patients Undergoing Surgery for Metastatic Spine Tumors: Analysis of the Metastatic Tumor Research and Outcomes Network (MTRON) Registry Dataset
Evaluation of Adverse Events and the Impact on Health-Related Outcomes in Patients Undergoing Surgery for Metastatic Spine Tumors: Analysis of the Metastatic Tumor Research and Outcomes Network (MTRON) Registry Dataset Open
Study Design This study is part of the AO Spine Metastatic Tumor Research and Outcomes Network [MTRON], an international multicenter prospective observational registry including patients with spinal metastases. Objectives This study aims t…
View article: POS0017 Bispecific T Cell-Engaging Antibodies to Target TRBV9+ Autoreactive T Cells in Axial Spondyloarthritis
POS0017 Bispecific T Cell-Engaging Antibodies to Target TRBV9+ Autoreactive T Cells in Axial Spondyloarthritis Open
View article: NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon
NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon Open
Mild periodic acid Schiff staining (mPAS) of human colonic tissue has been used to answer a variety of fundamental questions in germline and somatic genetics. mPAS stains sialic acids except when these glycans are modified by O-acetylation…
View article: Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA
Detection of Cancers Three Years prior to Diagnosis Using Plasma Cell-Free DNA Open
To explore how early cancers can be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities study, including 26 participants diagnosed with cancer…
View article: Author response: ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
Author response: ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1 Open
View article: Data-driven feedback augments ultrasound nanotheranostics in brain tumors
Data-driven feedback augments ultrasound nanotheranostics in brain tumors Open
The blood-brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease-related DNA from the brain unreliable. Here, we show that the acoustic emission content of focused ultraso…
View article: ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1
ME3BP-7 is a targeted cytotoxic agent that rapidly kills pancreatic cancer cells expressing high levels of monocarboxylate transporter MCT1 Open
Nearly 30% of pancreatic ductal adenocarcinomas (PDACs) exhibit a marked overexpression of monocarboxylate transporter 1 (MCT1) offering a unique opportunity for therapy. However, biochemical inhibitors of MCT1 have proven unsuccessful in …
View article: Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease
Impact of surgery and radiation on radicular pain and myotomic weakness in patients with metastatic spine disease Open
OBJECTIVE Surgery is typically indicated for mechanical pain in metastatic spine disease or severe neurological compromise, but how radicular pain responds to oncological treatment is not well described. The primary aim of this study was t…