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View article: SLC25A1 reprograms mitochondrial and fatty acid metabolism to promote the progression of acute myeloid leukemia
SLC25A1 reprograms mitochondrial and fatty acid metabolism to promote the progression of acute myeloid leukemia Open
Abnormal metabolic reprogramming is a hallmark of acute myeloid leukemia (AML), contributing to leukemia initiation, progression and drug resistance. The key mitochondrial citrate transporter SLC25A1 plays an essential role in regulating c…
View article: SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression
SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression Open
Mitochondria are cellular powerhouses that generate energy through the electron transport chain (ETC). The mitochondrial genome (mtDNA) encodes essential ETC proteins in a compartmentalized manner, however, the mechanism underlying metabol…
View article: P471: POLO-LIKE KINASE 4 INHIBITION INDUCED ANTI-LEUKAEMIC EFFECTS THROUGH HISTONE MODIFICATION IN TP53 MUTATED ACUTE MYELOID LEUKAEMIA
P471: POLO-LIKE KINASE 4 INHIBITION INDUCED ANTI-LEUKAEMIC EFFECTS THROUGH HISTONE MODIFICATION IN TP53 MUTATED ACUTE MYELOID LEUKAEMIA Open
Background: Current treatment for acute myeloid leukaemia (AML) entails intensive chemotherapy and allogeneic hematopoietic cell transplantation. However, these approaches have not been effective in patients with TP53 mutated AML and their…
View article: COVID‐19 metabolism: Mechanisms and therapeutic targets
COVID‐19 metabolism: Mechanisms and therapeutic targets Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) dysregulates antiviral signaling, immune response, and cell metabolism in human body. Viral genome and proteins hijack host metabolic network to support viral biogenesis and prop…
View article: Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness
Loss of sphingosine kinase 2 promotes the expansion of hematopoietic stem cells by improving their metabolic fitness Open
Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and replenish the hematopoietic system during myelosuppressive injury or aging. Expanding and rejuvenating HSCs for therapeutic purposes has been a long-sought go…
View article: In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies Open
Genome-wide CRISPR screens have been extremely useful in identifying therapeutic targets in diverse cancers by defining genes that are essential for malignant growth. However, most CRISPR screens were performed in vitro and thus cannot ide…
View article: Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication
Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication Open
View article: Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth Open
Proton export is often considered a detoxifying process in animal cells, with monocarboxylate symporters coexporting excessive lactate and protons during glycolysis or the Warburg effect. We report a novel mechanism by which lactate/H+ exp…
View article: Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis Open
View article: Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults
Redefining prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults Open
View article: Follistatin is a novel therapeutic target and biomarker in <scp>FLT</scp> 3/ <scp>ITD</scp> acute myeloid leukemia
Follistatin is a novel therapeutic target and biomarker in <span>FLT</span> 3/ <span>ITD</span> acute myeloid leukemia Open
Corrigendum7 August 2020Open Access Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia Bai-Liang He Bai-Liang He Search for more papers by this author Ning Yang Ning Yang Search for more papers by th…
View article: Follistatin is a novel therapeutic target and biomarker in <scp>FLT</scp> 3/ <scp>ITD</scp> acute myeloid leukemia
Follistatin is a novel therapeutic target and biomarker in <span>FLT</span> 3/ <span>ITD</span> acute myeloid leukemia Open
Internal tandem duplication of Fms-like tyrosine kinase 3 (FLT3/ITD) occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor response to conventional treatment and adverse outcome. Here, we reported that human FLT3/…
View article: Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia
Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia Open
Key Points SOX7 expression is silenced in common myeloid malignancies. SOX7 interacts directly with β-catenin and regulates the Wnt pathway in acute myeloid leukemia.
View article: Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish
Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish Open
Key Points Zebrafish idh1 plays an important role in the regulation of myelopoiesis and definitive hematopoiesis. Expression of human IDH1-R132H and its zebrafish orthologue induced an increase in myelopoiesis and 2-hydroxyglutrate.