Chunhua Zhou
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View article: Case Report: Diagnosis and treatment of congenital right atrial dissection associated with atrial aneurysm
Case Report: Diagnosis and treatment of congenital right atrial dissection associated with atrial aneurysm Open
Spontaneous atrial dissection and atrial aneurysm are extremely rare conditions. This may be the first reported case diagnosed in the fetal period and successfully treated with surgery under extracorporeal circulation in infancy. Although …
View article: Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study
Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study Open
Background Obesity is recognized as a prominent contributing factor for pancreatic diseases; however, the mechanisms remain elusive. We aimed to identify the mediating role of circulating proteins in these associations. Methods A two-step …
View article: Development and validation of web-based risk score predicting prognostic nomograms for elderly patients with primary colorectal lymphoma: A population-based study
Development and validation of web-based risk score predicting prognostic nomograms for elderly patients with primary colorectal lymphoma: A population-based study Open
Background and Objectives Primary colorectal lymphoma (PCL) is an infrequently occurring form of cancer, with the elderly population exhibiting an increasing prevalence of the disease. Furthermore, advanced age is associated with a poorer …
View article: Adequacy of EUS–guided fine-needle aspiration and fine-needle biopsy for next-generation sequencing in pancreatic malignancies: A systematic review and meta-analysis
Adequacy of EUS–guided fine-needle aspiration and fine-needle biopsy for next-generation sequencing in pancreatic malignancies: A systematic review and meta-analysis Open
Background and Objectives A majority of pancreatic malignancies are unresectable at the time of presentation and require EUS–guided fine-needle aspiration or fine-needle biopsy (EUS-FNA/FNB) for diagnosis. With the advent of precision ther…
View article: Dietary folate intake and serum klotho levels in adults aged 40–79 years: a cross-sectional study from the national health and nutrition examination survey 2007–2016
Dietary folate intake and serum klotho levels in adults aged 40–79 years: a cross-sectional study from the national health and nutrition examination survey 2007–2016 Open
Objective This study aims to explore the relationship between dietary folate intake and serum Klotho levels in adults from aged 40 to 79 years in the United States, seeking to elucidate the intricacies of their interaction. Methods Analyzi…
View article: An unusual case of duodenal neuroendocrine tumor presenting with melena diagnosed by EUS-guided fine-needle biopsy
An unusual case of duodenal neuroendocrine tumor presenting with melena diagnosed by EUS-guided fine-needle biopsy Open
A 56-year-old man presented with recurrent melena for half a month and underwent an upper gastrointestinal endoscopy; an eminence lesion (30 mm × 30 mm) was found in the descending part of the duodenum [Figure 1]. Imaging studies were subs…
View article: The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis
The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis Open
Background Growing evidence has shown that gut microbiome composition is associated with Biliary tract cancer (BTC), but the causality remains unknown. This study aimed to explore the causal relationship between gut microbiota and BTC, con…
View article: Diagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study
Diagnostic accuracy of magnetically guided capsule endoscopy with a detachable string for detecting oesophagogastric varices in adults with cirrhosis: prospective multicentre study Open
Objective To evaluate the diagnostic accuracy and safety of using magnetically guided capsule endoscopy with a detachable string (ds-MCE) for detecting and grading oesophagogastric varices in adults with cirrhosis. Design Prospective multi…
View article: Lipid alterations play a role in the integration of PD-1/PD-L1 inhibitors and anlotinib for the treatment of advanced non–small-cell lung cancer
Lipid alterations play a role in the integration of PD-1/PD-L1 inhibitors and anlotinib for the treatment of advanced non–small-cell lung cancer Open
Background Studies have shown that integrating anlotinib with programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors enhances survival rates among progressive non–small-cell lung cancer (NSCLC) patients lacking driver mutat…
View article: Mendelian Randomization Unveiling Blood CTRB2, RSPO3, KLOTB, and ROR1 as Protein Mediators of Obesity-Pancreatic Disease Association
Mendelian Randomization Unveiling Blood CTRB2, RSPO3, KLOTB, and ROR1 as Protein Mediators of Obesity-Pancreatic Disease Association Open
View article: 13P Efficacy and biomarker exploration of anlotinib plus penpulimab for extensive-stage small-cell lung cancer who failed previous platinum-based chemotherapy: Results from a phase II perspective trial
13P Efficacy and biomarker exploration of anlotinib plus penpulimab for extensive-stage small-cell lung cancer who failed previous platinum-based chemotherapy: Results from a phase II perspective trial Open
The phase II ALTER1202 trial demonstrated that patients who received anlotinib after failing at least two systemic chemotherapy regimens exhibited improved progression-free survival (PFS) and overall survival (OS) compared to the placebo g…
View article: Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study
Causal link between gut microbiota and four types of pancreatitis: a genetic association and bidirectional Mendelian randomization study Open
Background A number of recent observational studies have indicated a correlation between the constitution of gut microbiota and the incidence of pancreatitis. Notwithstanding, observational studies are unreliable for inferring causality be…
View article: Artificial Intelligence in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration/Biopsy (EUS-FNA/B) for Solid Pancreatic Lesions: Opportunities and Challenges
Artificial Intelligence in Endoscopic Ultrasonography-Guided Fine-Needle Aspiration/Biopsy (EUS-FNA/B) for Solid Pancreatic Lesions: Opportunities and Challenges Open
Solid pancreatic lesions (SPLs) encompass a variety of benign and malignant diseases and accurate diagnosis is crucial for guiding appropriate treatment decisions. Endoscopic ultrasonography-guided fine-needle aspiration/biopsy (EUS-FNA/B)…
View article: Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria
Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria Open
Chronic pancreatitis (CP) is a progressive and irreversible fibroinflammatory disorder, accompanied by pancreatic exocrine insufficiency and dysregulated gut microbiota. Recently, accumulating evidence has supported a correlation between g…
View article: A deep learning model using hyperspectral image for <scp>EUS‐FNA</scp> cytology diagnosis in pancreatic ductal adenocarcinoma
A deep learning model using hyperspectral image for <span>EUS‐FNA</span> cytology diagnosis in pancreatic ductal adenocarcinoma Open
Background and Aims Endoscopic ultrasonography‐guided fine‐needle aspiration/biopsy (EUS‐FNA/B) is considered to be a first‐line procedure for the pathological diagnosis of pancreatic cancer owing to its high accuracy and low complication …
View article: Hypofractionated radiotherapy with immunochemotherapy for extensive-stage small-cell lung cancer
Hypofractionated radiotherapy with immunochemotherapy for extensive-stage small-cell lung cancer Open
Introduction The combination of a PD-L1 inhibitor plus carboplatin/cisplatin and etoposide (EC/EP) has become a new standard first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC). Combining concurrent palliative hypofra…
View article: A combined radiomic model distinguishing GISTs from leiomyomas and schwannomas in the stomach based on endoscopic ultrasonography images
A combined radiomic model distinguishing GISTs from leiomyomas and schwannomas in the stomach based on endoscopic ultrasonography images Open
Background Endoscopic ultrasonography (EUS) is recommended as the best tool for evaluating gastric subepithelial lesions (SELs); nonetheless, it has difficulty distinguishing gastrointestinal stromal tumors (GISTs) from leiomyomas and schw…
View article: PD-1 inhibitor versus bevacizumab in combination with platinum-based chemotherapy for first-line treatment of advanced lung adenocarcinoma: A retrospective-real world study
PD-1 inhibitor versus bevacizumab in combination with platinum-based chemotherapy for first-line treatment of advanced lung adenocarcinoma: A retrospective-real world study Open
Background Chemotherapy combined with immunotherapy or anti-vascular therapy is both recommended by guidelines for first-line treatment of lung adenocarcinoma. However, no head-to-head clinical trial has ever compared which strategy is the…
View article: Sintilimab plus docetaxel as second-line therapy of advanced non-small cell lung cancer without targetable mutations: a phase II efficacy and biomarker study
Sintilimab plus docetaxel as second-line therapy of advanced non-small cell lung cancer without targetable mutations: a phase II efficacy and biomarker study Open
View article: A real‐world comparison between neoadjuvant chemoimmunotherapy and chemotherapy alone for resectable non‐small cell lung cancer
A real‐world comparison between neoadjuvant chemoimmunotherapy and chemotherapy alone for resectable non‐small cell lung cancer Open
Background The impact of neoadjuvant chemoimmunotherapy on pulmonary resection and related outcomes had been poorly reported in previous studies. The present study aims to clarify the efficacy and safety of neoadjuvant chemoimmunotherapy, …
View article: The efficacy and safety of albumin-bound paclitaxel plus carboplatin as neoadjuvant therapy for potentially resectable lung squamous cell carcinoma: a real-world retrospective cohort study
The efficacy and safety of albumin-bound paclitaxel plus carboplatin as neoadjuvant therapy for potentially resectable lung squamous cell carcinoma: a real-world retrospective cohort study Open
In this study, we found a high SCR (67%) and mPR (35%) after ab-PC treatment for stage IIIA and IIIB potentially resectable LSCC. ab-PC maybe considered a neoadjuvant chemotherapy option for potentially resectable LSCC patients.
View article: Sintilimab Plus Docetaxel as Second-Line Therapy of Advanced Non-Small Cell Lung Cancer Without Targetable Mutations: A Phase II Efficacy and Biomarker Study
Sintilimab Plus Docetaxel as Second-Line Therapy of Advanced Non-Small Cell Lung Cancer Without Targetable Mutations: A Phase II Efficacy and Biomarker Study Open
View article: Efficacy and Safety of Different Doses of Bevacizumab Combined With Pemetrexed and Platinum in First-Line Treatment of Advanced NSCLC: A Retrospective-Real World Study
Efficacy and Safety of Different Doses of Bevacizumab Combined With Pemetrexed and Platinum in First-Line Treatment of Advanced NSCLC: A Retrospective-Real World Study Open
Background: Bevacizumab was demonstrated to have efficacy in patients with NSCLC. However, application of different doses of bevacizumab in different clinical trials was overlooked. This study aims to investigate the effects and safety of …
View article: The Application of Magnetic-Controlled Capsule Gastroscopy in Patients Refusing C-EGD: A Single-Center 5-Year Observational Study
The Application of Magnetic-Controlled Capsule Gastroscopy in Patients Refusing C-EGD: A Single-Center 5-Year Observational Study Open
Background and Aims. Screening for gastric diseases in symptomatic outpatients with conventional esophagogastroduodenoscopy (C-EGD) is expensive and has poor compliance. We aimed to explore the efficiency and safety of magnetic-controlled …
View article: A Large Real-World Study on the Effectiveness of the Combined Inhibition of EGFR and MET in EGFR-Mutant Non-Small-Cell Lung Cancer After Development of EGFR-TKI Resistance
A Large Real-World Study on the Effectiveness of the Combined Inhibition of EGFR and MET in EGFR-Mutant Non-Small-Cell Lung Cancer After Development of EGFR-TKI Resistance Open
Background MET proto-oncogene amplification (amp) is an important mechanism underlying acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the optimal treatment strategy after acquirin…
View article: Prognosis and Concurrent Genomic Alterations in Patients With Advanced NSCLC Harboring MET Amplification or MET Exon 14 Skipping Mutation Treated With MET Inhibitor: A Retrospective Study
Prognosis and Concurrent Genomic Alterations in Patients With Advanced NSCLC Harboring MET Amplification or MET Exon 14 Skipping Mutation Treated With MET Inhibitor: A Retrospective Study Open
Background MET amplification or METex14 skipping mutations are uncommon oncogenic events in NSCLC patients. Clinicopathological characteristics, concurrent gene alterations, and prognosis of MET TKIs in these patients are yet to be elucida…
View article: An Improved Energy Management Strategy for 24t Heavy-Duty Hybrid Emergency Rescue Vehicle With Dual-Motor Torque Increasing
An Improved Energy Management Strategy for 24t Heavy-Duty Hybrid Emergency Rescue Vehicle With Dual-Motor Torque Increasing Open
Emergency rescue vehicles are special equipment for fire, flood, earthquake and other disasters. They need to have high efficiency and high mobility under various terrain and road conditions. The fuel economy of emergency rescue vehicles i…
View article: A Novel Immersed Boundary Method Implemented by Imposing Reconstructed Velocity on Virtual Boundary
A Novel Immersed Boundary Method Implemented by Imposing Reconstructed Velocity on Virtual Boundary Open
In this paper, a novel immersed boundary method is presented for simulating incompressible flows governed by Navier-Stokes equations.A virtual boundary is formed by the cell edges (for two-dimensional cases) in the vicinity of the immersed…
View article: <i>Bifidobacterium longum</i> alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation
<i>Bifidobacterium longum</i> alleviates irritable bowel syndrome-related visceral hypersensitivity and microbiota dysbiosis via Paneth cell regulation Open
Although the oral administration of Bifidobacterium longum (B. longum) relieves the signs of irritable bowel syndrome (IBS) in clinical settings, the mechanisms underlying its effects are unclear. In this study, we evaluated the precise ef…
View article: Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non–Small Cell Lung Cancer After Second-Line Treatment Failure
Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non–Small Cell Lung Cancer After Second-Line Treatment Failure Open
ClinicalTrials.gov Identifier: NCT03652857.