Dong Zhou
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View article: IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization
IGF2BP2 Drives Thyroid Cancer Dedifferentiation Through m6A-Dependent STAT1 mRNA Destabilization Open
Thyroid cancer is the most common endocrine malignancy globally. While papillary thyroid carcinoma (PTC) typically exhibits favorable prognosis, a subset undergoes dedifferentiation into anaplastic thyroid carcinoma (ATC), an aggressive, t…
View article: Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study
Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study Open
Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who a…
View article: Factors associated with long‐term outcomes in people with new onset refractory epilepticus: A single‐center cohort study
Factors associated with long‐term outcomes in people with new onset refractory epilepticus: A single‐center cohort study Open
Objective New onset refractory status epilepticus (NORSE) is a neurologic emergency in people without a history of active epilepsy or other preexisting neurological disorders. There are not many studies reporting on the long‐term outcomes …
View article: A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures Open
Objectives This randomized, double‐blind, placebo‐controlled study (NCT04557085), conducted in China, Japan, and the Republic of Korea, evaluated the efficacy and safety of adjunctive cenobamate in patients with uncontrolled focal seizures…
View article: Using machine learning models to predict the risk of mild cognitive impairment for COPD patients: A multi-cohort study
Using machine learning models to predict the risk of mild cognitive impairment for COPD patients: A multi-cohort study Open
The machine learning model accurately predicts MCI risk in COPD patients, enabling timely clinical interventions and improved care through early identification of high-risk individuals.
View article: Volcano-like relation between surface confinement and heat generated in electrical double layers
Volcano-like relation between surface confinement and heat generated in electrical double layers Open
Electrical double layer (EDL) formation generates heat; however, the underlying mechanisms remain poorly understood, particularly under surface confinement. In this work, constant-potential molecular dynamics simulations were adopted to de…
View article: Association between frailty transitions and chronic lung disease incidence: findings from four national cohort studies
Association between frailty transitions and chronic lung disease incidence: findings from four national cohort studies Open
Background The association between changes in frailty status and the prevalence of chronic lung diseases (CLD) is critical. This study aims to explore the relationship between variations in frailty status and incidence of CLD. Methods This…
View article: EAFormer: Edge-Aware Guided Adaptive Frequency-Navigator Network for Image Restoration
EAFormer: Edge-Aware Guided Adaptive Frequency-Navigator Network for Image Restoration Open
Although many deep learning-based image restoration networks have emerged in various image restoration tasks, most can only perform well in a specific type of restoration task and still face challenges in the general performance of image r…
View article: ARHGEF6 downregulation as a key mediator of tumor cell apoptosis in breast cancer
ARHGEF6 downregulation as a key mediator of tumor cell apoptosis in breast cancer Open
The present study aimed to identify novel clinical biomarkers for breast cancer (BRCA) through bioinformatics analyses and cellular experiments, due to the ongoing need for improved diagnosis and prognosis in BRCA. The GSE21422 and The Can…
View article: Light-Weight Cross-Modal Enhancement Method with Benchmark Construction for UAV-based Open-Vocabulary Object Detection
Light-Weight Cross-Modal Enhancement Method with Benchmark Construction for UAV-based Open-Vocabulary Object Detection Open
Open-Vocabulary Object Detection (OVD) faces severe performance degradation when applied to UAV imagery due to the domain gap from ground-level datasets. To address this challenge, we propose a complete UAV-oriented solution that combines …
View article: Functional/dissociative seizures: Proposal for a new diagnostic label and definition by the <scp>ILAE</scp> task force
Functional/dissociative seizures: Proposal for a new diagnostic label and definition by the <span>ILAE</span> task force Open
The acceptability and validity of the term "psychogenic nonepileptic seizures" (PNES) have been questioned. Currently, numerous alternative terms, such as “conversion,” “dissociative,” “functional,” “attacks,” and “events,” are used in bot…
View article: Efficacy and safety of ruxolitinib combined with steroids for first-line treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: a single-center, real-world experience
Efficacy and safety of ruxolitinib combined with steroids for first-line treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: a single-center, real-world experience Open
Introduction Despite the increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT), graft-versus-host disease (GVHD) remains the main cause of morbidity and mortality, significantly impacting HSCT outcomes. Steroids …
View article: Altered <scp>EEG</scp> Microstate Dynamics in First Unprovoked Seizure and Newly Diagnosed Epilepsy Patients
Altered <span>EEG</span> Microstate Dynamics in First Unprovoked Seizure and Newly Diagnosed Epilepsy Patients Open
Objective To identify the Electroencephalogram (EEG) microstate characteristics that can distinguish between patients with first unprovoked seizure (FUS) and newly diagnosed epilepsy (NDE), providing insight into predicting the progress of…
View article: Safety, Tolerability, and Efficacy of Adjunctive Brivaracetam in Japanese and Chinese Patients with Focal-Onset Seizures: Interim Analysis of a Phase 3 Open-Label Extension Trial
Safety, Tolerability, and Efficacy of Adjunctive Brivaracetam in Japanese and Chinese Patients with Focal-Onset Seizures: Interim Analysis of a Phase 3 Open-Label Extension Trial Open
ClinicalTrials.gov NCT03250377. Graphical abstract available for this article.
View article: Metabolic abnormalities in the insula of patients with interictal migraine without aura: a prospective cross-sectional study
Metabolic abnormalities in the insula of patients with interictal migraine without aura: a prospective cross-sectional study Open
The dysfunction or loss of neurons and glial cells, and excitatory neurotransmitter conversion imbalance may be the key changes in the insula of interictal MWoA patients. HF headaches are characterized by hypometabolism, which may be cause…
View article: Multi-Response Au-Nanohybrid Composite Triggered NIR-Light for Effective Anti-Tumor Therapy in Animal Model
Multi-Response Au-Nanohybrid Composite Triggered NIR-Light for Effective Anti-Tumor Therapy in Animal Model Open
This nanohybrid system represents a promising strategy for improving the efficacy of chemotherapy and reducing toxicity in cancer treatment. It enhances drug enrichment and release in tumor tissues while minimizing the impact on normal tis…
View article: Prevalence, clinical characteristics, and risk factors for psychosis in people with epilepsy: A multicenter retrospective cohort study
Prevalence, clinical characteristics, and risk factors for psychosis in people with epilepsy: A multicenter retrospective cohort study Open
Objective We aimed to assess the prevalence, clinical characteristics, and risk factors for psychosis in a cohort of people with epilepsy in West China. Methods We used retrospective information from databases of three tertiary epilepsy ce…
View article: Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy
Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy Open
The International League Against Epilepsy (ILAE) has updated the operational classification of epileptic seizures, building upon the framework established in 2017. This revision, informed by the implementation experience, involved a workin…
View article: Sodium channel blockers for the treatment of focal epilepsy: A Chinese expert consensus
Sodium channel blockers for the treatment of focal epilepsy: A Chinese expert consensus Open
This is a Chinese expert consensus on the use of SCBs in focal epilepsy developed using the modified Delphi method. These recommendations can help clinicians in their practice and guide future research.
View article: Connectome architecture for gray matter atrophy and surgical outcomes in temporal lobe epilepsy
Connectome architecture for gray matter atrophy and surgical outcomes in temporal lobe epilepsy Open
Objective Temporal lobe epilepsy ( TLE ) has been recognized as a network disorder with widespread gray matter atrophy. However, the role of connectome architecture in shaping morphological alterations and identifying atrophy epicenters re…
View article: Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions
Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions Open
Background Mesial temporal lobe epilepsy (mTLE) is the most common form of focal epilepsy, often associated with hippocampal sclerosis. Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and progression. Metho…