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View article: RADT-11. HIGH INCIDENCE AND OUTCOME OF MULTICENTRIC HIGH GRADE GLIOMA (MCHGG) COMPARED TO UNICENTRIC HIGH GRADE GLIOMA (UCHGG), IN A MIDWEST REGIONAL CANCER CENTER SERVING A RURAL OUTREACH AREA, WHICH DRAWS FROM A 100 MILE RADIUS
RADT-11. HIGH INCIDENCE AND OUTCOME OF MULTICENTRIC HIGH GRADE GLIOMA (MCHGG) COMPARED TO UNICENTRIC HIGH GRADE GLIOMA (UCHGG), IN A MIDWEST REGIONAL CANCER CENTER SERVING A RURAL OUTREACH AREA, WHICH DRAWS FROM A 100 MILE RADIUS Open
A retrospective review was conducted on patients diagnosed with high grade glioma between January 2022 and January 2025. Patient demographics including age, gender, geographic area, number of discrete lesions, molecular alterations includi…
View article: Mechanical optimization of plate-screw interfaces in variable-angle locking systems: a parametric study
Mechanical optimization of plate-screw interfaces in variable-angle locking systems: a parametric study Open
Introduction Variable-angle locking systems offer increased surgical flexibility by permitting off-axis screw insertion, with some designs allowing angulation up to 15°. However, clinical challenges such as screw loosening and insufficient…
View article: Proton beam radiation therapy vs. photon radiation therapy and the overall survival of adult and pediatric patients diagnosed with sarcoma
Proton beam radiation therapy vs. photon radiation therapy and the overall survival of adult and pediatric patients diagnosed with sarcoma Open
Background The use of proton beam radiation therapy (PBT) has increased in patients diagnosed with sarcoma. However, there is a lack of information about its survival benefit in these patients. Objective We want to investigate the associat…
View article: Proton beam radiation therapy and the overall survival of adult and pediatric patients diagnosed with central nervous system tumors
Proton beam radiation therapy and the overall survival of adult and pediatric patients diagnosed with central nervous system tumors Open
Patients who received PBT had longer OS compared to patients who received photon RT (HR:0.67 [95% CI: 0.64-0.71], p < 0.001). In the subset analyses stratified by surgery, the use of PBT was associated with improved OS compared to photon R…
View article: Modified citrus pectin protects aortic dissection development involving macrophage pyroptosis
Modified citrus pectin protects aortic dissection development involving macrophage pyroptosis Open
MCP could improve patient outcomes and reduce progression to severe forms of AD. Clinically, MCP could serve as supportive therapy to prevent and delay aortic dissection, particularly during the acute stage of uncomplicated type B AD in pa…
View article: A lightweight network for traffic sign detection via multiple scale context awareness and semantic information guidance
A lightweight network for traffic sign detection via multiple scale context awareness and semantic information guidance Open
View article: Monochromatic Responsive HOF Heterostructures via VIA‐Group‐Based Framework Hybridization for Fully‐Covert Photonic Barcode
Monochromatic Responsive HOF Heterostructures via VIA‐Group‐Based Framework Hybridization for Fully‐Covert Photonic Barcode Open
Luminescent responsive heterostructures with region‐domained emission and integrated responsiveness exhibit great potential in information security, but always suffer from the direct exposure of fingerprint information at the initial state…
View article: Comparison of overall survival of adult and pediatric osteosarcoma patients using the national cancer database
Comparison of overall survival of adult and pediatric osteosarcoma patients using the national cancer database Open
View article: Comparison of overall survival of adult and pediatric osteosarcoma patients using the National Cancer Database
Comparison of overall survival of adult and pediatric osteosarcoma patients using the National Cancer Database Open
Background: Differences in overall survival (OS) between children and adult patients diagnosed with osteosarcoma are poorly understood. The objective of this study is to compare the OS of pediatric and adult patients diagnosed with osteosa…
View article: Developing a novel dosiomics model to predict treatment failures following lung stereotactic body radiation therapy
Developing a novel dosiomics model to predict treatment failures following lung stereotactic body radiation therapy Open
Purpose The purpose of this study was to investigate the dosiomics features of the interplay between CT density and dose distribution in lung SBRT plans, and to develop a model to predict treatment failure following lung SBRT treatment. Me…
View article: Differentiated Intra‐Ligand Charge Transfer Boosting Multicolor Responsive MOF Heterostructures as Robust Anti‐Counterfeiting Labels
Differentiated Intra‐Ligand Charge Transfer Boosting Multicolor Responsive MOF Heterostructures as Robust Anti‐Counterfeiting Labels Open
Metal–organic framework (MOF) heterostructures with hybrid architectures and abundant functional sites possess great potential applications in advanced information security, yet still suffer from the harsh stimuli mechanisms with restraine…
View article: Enhancing Survival Outcome Predictions in Metastatic Non-Small Cell Lung Cancer Through PET Radiomics Analysis
Enhancing Survival Outcome Predictions in Metastatic Non-Small Cell Lung Cancer Through PET Radiomics Analysis Open
(1) Background: Advanced-stage lung cancer poses significant management challenges. The goal of this study was to identify crucial clinical and PET radiomics features that enable prognostic stratification for predicting outcomes. (2) Metho…
View article: Combination Immunotherapy With Radiotherapy in Non‐Small Cell Lung Cancer: A Review of Evidence
Combination Immunotherapy With Radiotherapy in Non‐Small Cell Lung Cancer: A Review of Evidence Open
Background Radiotherapy plays a fundamental role in the treatment of patients with all stages of non‐small‐cell lung cancer (NSCLC). The emergence of immune checkpoint inhibitors (ICIs) has transformed the standard of care in these patient…
View article: Role of immunotherapy in the overall survival of gastrointestinal cancer patients with liver metastases
Role of immunotherapy in the overall survival of gastrointestinal cancer patients with liver metastases Open
Aim: To investigate the role of immunotherapy in the overall survival (OS) of gastrointestinal cancer patients who have liver metastases at the time of the primary site cancer diagnosis.Materials & methods: Survival outcome w…
View article: The prognostic significance of androgen receptor expression in gliomas
The prognostic significance of androgen receptor expression in gliomas Open
View article: Time interval between neoadjuvant radiation therapy and surgery and overall survival of rectal cancer patients
Time interval between neoadjuvant radiation therapy and surgery and overall survival of rectal cancer patients Open
Aim: To investigate the association of time interval between neoadjuvant RT and surgery (RS-interval) with pathological complete response (pCR) and overall survival (OS) of rectal cancer patients. Methods: We used the National Cancer Datab…
View article: Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance
Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance Open
Receptor tyrosine kinases (RTKs) control stem cell maintenance vs. differentiation decisions. Casitas B-lineage lymphoma (CBL) family ubiquitin ligases are negative regulators of RTKs, but their stem cell regulatory roles remain unclear. H…
View article: High Throughput Profiling Identified Pa-L106r Amino Acid Substitution in A(H1n1)Pdm09 Influenza Virus that Confers Reduced Susceptibility to Baloxavir In Vitro
High Throughput Profiling Identified Pa-L106r Amino Acid Substitution in A(H1n1)Pdm09 Influenza Virus that Confers Reduced Susceptibility to Baloxavir In Vitro Open
View article: Enhancing Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy Through MRI Radiomics Analysis
Enhancing Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy Through MRI Radiomics Analysis Open
Purpose: Pancreatic cancer is an extremely aggressive and deadly cancer with a 5-year survival rate of less than 10%. Our study aims to establish an MRI radiomics-based model to predict survival for borderline resectable and locally advanc…
View article: Immunotherapy Plus Chemoradiation Improves Overall Survival in Stage IV Esophageal Cancer: A Cohort Study
Immunotherapy Plus Chemoradiation Improves Overall Survival in Stage IV Esophageal Cancer: A Cohort Study Open
View article: PB0941 Pancreatic Cancer Cells and Derived Microvesicles Induce Thrombosis in Coagulation Factor Deficient Mouse Models
PB0941 Pancreatic Cancer Cells and Derived Microvesicles Induce Thrombosis in Coagulation Factor Deficient Mouse Models Open
View article: Prognostic Value of Tumor Volume Reduction during Radiotherapy in Patients with Locally Advanced Cervical Cancer in Different Risk Groups
Prognostic Value of Tumor Volume Reduction during Radiotherapy in Patients with Locally Advanced Cervical Cancer in Different Risk Groups Open
View article: Peer Review #2 of "Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site (v0.2)"
Peer Review #2 of "Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site (v0.2)" Open
Background and purpose Stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) are both treatments shown to be effective in treating brain metastases (BMs).However, it is unknown how these treatments compare i…
View article: Peer Review #3 of "Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site (v0.1)"
Peer Review #3 of "Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site (v0.1)" Open
Background and purpose Stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) are both treatments shown to be effective in treating brain metastases (BMs).However, it is unknown how these treatments compare i…
View article: Peer Review #2 of "Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site (v0.1)"
Peer Review #2 of "Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site (v0.1)" Open
Background and purpose Stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) are both treatments shown to be effective in treating brain metastases (BMs).However, it is unknown how these treatments compare i…
View article: Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site
Single fraction stereotactic radiosurgery and fractionated stereotactic radiotherapy provide equal prognosis with overall survival in patients with brain metastases at diagnosis without surgery at primary site Open
Background and purpose Stereotactic radiosurgery (SRS) and fractionated stereotactic radiation therapy (SRT) are both treatments shown to be effective in treating brain metastases (BMs). However, it is unknown how these treatments compare …
View article: Cbl and Cbl-b Ubiquitin Ligases are Essential for Intestinal Epithelial Stem Cell Maintenance
Cbl and Cbl-b Ubiquitin Ligases are Essential for Intestinal Epithelial Stem Cell Maintenance Open
SUMMARY Among the signaling pathways that control the stem cell self-renewal and maintenance vs. acquisition of differentiated cell fates, those mediated by receptor tyrosine kinase (RTK) activation are well established as key players. CBL…
View article: Figures S1 and S2 from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer
Figures S1 and S2 from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer Open
Figure S1. BrPA inhibits MUC1-mediated nucleotide metabolism. Figure S2. Immunohistochemical staining for MUC1 in tumor sections.
View article: Figures S1 and S2 from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer
Figures S1 and S2 from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer Open
Figure S1. BrPA inhibits MUC1-mediated nucleotide metabolism. Figure S2. Immunohistochemical staining for MUC1 in tumor sections.
View article: Data from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer
Data from MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer Open
Purpose: MUC1, an oncogene overexpressed in multiple solid tumors, including pancreatic cancer, reduces overall survival and imparts resistance to radiation and chemotherapies. We previously identified that MUC1 facilitates g…