Yuelong Shu
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View article: Generalized biological foundation model with unified nucleic acid and protein language
Generalized biological foundation model with unified nucleic acid and protein language Open
The language of biology, encoded in DNA, RNA and proteins, forms the foundation of life but remains challenging to decode owing to its complexity. Traditional computational methods often struggle to integrate information across these molec…
View article: Chimeric hemagglutinin and M2 mRNA vaccine for broad influenza subtype protection
Chimeric hemagglutinin and M2 mRNA vaccine for broad influenza subtype protection Open
Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics, developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the…
View article: Risk evaluation of newly emerging flu viruses based on genomic sequences and AI
Risk evaluation of newly emerging flu viruses based on genomic sequences and AI Open
The recent resurgence of highly pathogenic avian influenza H5N1 viruses in North America and Europe has heightened global concerns regarding potential influenza pandemics. Despite significant progress in the surveillance and prevention of …
View article: Efficacy of Tecovirimat and Cidofovir Against MPXV-Induced Pneumonia, Skin Lesion, and Arthritis in the High-Risk Population-Relevant SCID Mouse Model
Efficacy of Tecovirimat and Cidofovir Against MPXV-Induced Pneumonia, Skin Lesion, and Arthritis in the High-Risk Population-Relevant SCID Mouse Model Open
On February 27, 2025, WHO maintained monkeypox as a PHEIC following its third round of assessment. Human monkeypox virus infection primarily manifests with fever, lymphadenopathy, and rash. Severe cases may develop pneumonia, encephalitis,…
View article: <i>Faecalibacterium prausnitzii</i> Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS‐Induced Colitis Mice Model
<i>Faecalibacterium prausnitzii</i> Colonization Attenuates Gut Inflammation and Epithelial Damage in a DSS‐Induced Colitis Mice Model Open
Background: Reduction of Faecalibacterium prausnitzii abundance is related to inflammatory bowel diseases (IBDs), and supplement of it exists protective effects. Aim: This study aimed to establish a F. prausnitzii ‐colonized mouse model an…
View article: Using artificial intelligence to document the hidden RNA virosphere
Using artificial intelligence to document the hidden RNA virosphere Open
Current metagenomic tools can fail to identify highly divergent RNA viruses. We developed a deep learning algorithm, termed LucaProt, to discover highly divergent RNA-dependent RNA polymerase (RdRP) sequences in 10,487 metatranscriptomes g…
View article: Generalized Biological Foundation Model with Unified Nucleic Acid and Protein Language
Generalized Biological Foundation Model with Unified Nucleic Acid and Protein Language Open
The language of biology, encoded in DNA, RNA, and proteins, forms the foundation of life but remains challenging to decode due to its complexity. Traditional computational methods often struggle to integrate information across these molecu…
View article: Challenges and Strategies for Influenza Response After COVID-19 Pandemic
Challenges and Strategies for Influenza Response After COVID-19 Pandemic Open
After the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) pandemic in March 2020, the implementation of the most effective interventions became a paramount public health priority in the global response to t…
View article: Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic
Spatiotemporal genotype replacement of H5N8 avian influenza viruses contributed to H5N1 emergence in 2021/2022 panzootic Open
Since 2020, clade 2.3.4.4b highly pathogenic avian influenza H5N8 and H5N1 viruses have swept through continents, posing serious threats to the world. Through comprehensive analyses of epidemiological, genetic, and bird migration data, we …
View article: Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies
Association between Statins Administration and Influenza Susceptibility: A Systematic Review and Meta-Analysis of Longitudinal Studies Open
Previous studies reported that the association between statins use and influenza infection was contradictory. A systematic review and meta-analysis of longitudinal studies were performed to determine the association between statins use and…
View article: Development of a Novel Enema Smart Hydrogel for Ulcerative Colitis (UC) Treatment
Development of a Novel Enema Smart Hydrogel for Ulcerative Colitis (UC) Treatment Open
Inflammatory Bowel Diseases (IBD), including Ulcerative Colitis (UC) and Crohn’s Disease (CD), are chronic autoimmune diseases with recurrent patterns that are not fully understood. In this study, a novel MC/HA-Me enema smart hydrogel was …
View article: Genetic determinants of IgG antibody response to COVID-19 vaccination
Genetic determinants of IgG antibody response to COVID-19 vaccination Open
Human humoral immune responses to SARS-CoV-2 vaccines exhibit substantial inter-individual variability and have been linked to vaccine efficacy. To elucidate the underlying mechanism behind this variability, we conducted a genome-wide asso…
View article: Impact of Ambient Air Pollutants on Influenza-like illness, Influenza A and Influenza B: A Nationwide Time-Series Study in China
Impact of Ambient Air Pollutants on Influenza-like illness, Influenza A and Influenza B: A Nationwide Time-Series Study in China Open
Influenza constitutes a critical respiratory infection that imposes significant public health burdens. The precise influence of these pollutants on influenza activity remains unclear. This study aimed to investigate the effects of differen…
View article: Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro
Influenza H7N9 virus disrupts the monolayer human brain microvascular endothelial cells barrier in vitro Open
Influenza H7N9 virus causes human infections with about 40% case fatality rate. The severe cases usually present with pneumonia; however, some present with central nervous system complications. Pneumonia syndrome is attributed to the cytok…
View article: Effect of seasonal coronavirus immune imprinting on the immunogenicity of inactivated COVID-19 vaccination
Effect of seasonal coronavirus immune imprinting on the immunogenicity of inactivated COVID-19 vaccination Open
Background Pre-existing cross-reactive immunity among different coronaviruses, also termed immune imprinting, may have a comprehensive impact on subsequent SARS-CoV-2 infection and COVID-19 vaccination effectiveness. Here, we aim to explor…
View article: The truncated IFITM3 facilitates the humoral immune response in inactivated influenza vaccine-vaccinated mice via interaction with CD81
The truncated IFITM3 facilitates the humoral immune response in inactivated influenza vaccine-vaccinated mice via interaction with CD81 Open
A single-nucleotide polymorphism (SNP) rs12252-C of interferon-induced transmembrane protein 3 (IFITM3), resulting in a truncated IFITM3 protein lacking 21 N-terminus amino acids, is associated with severe influenza infection in the Chines…
View article: Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential
Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential Open
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection and spillover among them. We ch…
View article: A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines
A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines Open
Seasonal influenza A viruses continue to pose a public health threat, and current vaccines are not sufficiently effective because of virus mutation. There is an urgent need to develop a broad-protection influenza A vaccine. Our team previo…
View article: Evolution of Avian Influenza Virus (H3) with Spillover into Humans, China
Evolution of Avian Influenza Virus (H3) with Spillover into Humans, China Open
The continuous evolution of avian influenza viruses (AIVs) of subtype H3 in China and the emergence of human infection with AIV subtype H3N8 highlight their threat to public health. Through surveillance in poultry-associated environments d…
View article: Quantifying the rebound of influenza epidemics after the adjustment of zero-COVID policy in China
Quantifying the rebound of influenza epidemics after the adjustment of zero-COVID policy in China Open
The coexistence of coronavirus disease 2019 (COVID-19) and seasonal influenza epidemics has become a potential threat to human health, particularly in China in the oncoming season. However, with the relaxation of nonpharmaceutical interven…
View article: Factors affecting the immunogenicity of influenza vaccines in human
Factors affecting the immunogenicity of influenza vaccines in human Open
Background The influenza viruses pose a threat to human health and medical services, and vaccination is an important way to prevent infection. However, the effectiveness of influenza vaccines is affected by various aspects. This study aime…
View article: Genetic variants in BAT2 are associated with immune responsiveness to influenza vaccination
Genetic variants in BAT2 are associated with immune responsiveness to influenza vaccination Open
Background: Influenza is a global public health problem for its detrimental impact on human health. Annual vaccination is the most effective prevention of influenza infection. Identifying host genetic factors associated with the responsive…
View article: NAN342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice
NAN342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice Open
Objective: Influenza B virus is a significant respiratory pathogen responsible for seasonal influenza. In recent years the B/Yamagata lineage has demonstrated a rapid increase, predominantly featuring the neuraminidase (NA) N342K mutation.…
View article: Quantifying the rebound of influenza epidemics after relaxing nonpharmaceutical interventions during the coronavirus disease 2019 pandemic in China
Quantifying the rebound of influenza epidemics after relaxing nonpharmaceutical interventions during the coronavirus disease 2019 pandemic in China Open
The co-existence of coronavirus disease 2019 (COVID-19) and seasonal influenza epidemics has become a potential threat to human health, particularly in China in the oncoming season. However, with the relaxation of nonpharmaceutical interve…
View article: Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study
Mechanisms for the circulation of influenza A(H3N2) in China: A spatiotemporal modelling study Open
Circulation of seasonal influenza is the product of complex interplay among multiple drivers, yet characterizing the underlying mechanism remains challenging. Leveraging the diverse seasonality of A(H3N2) virus and abundant climatic space …
View article: Factors affecting the immunogenicity of influenza vaccines in human
Factors affecting the immunogenicity of influenza vaccines in human Open
Background: The influenza viruses pose a threat to human health and medical services, and vaccination is an important way to prevent infection. However, the effectiveness of influenza vaccines is affected by various aspects. This study aim…
View article: Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China
Epidemiology, evolution, and biological characteristics of H6 avian influenza viruses in China Open
H6 avian influenza virus (AIV) is one of the most prevalent AIV subtypes in birds globally. To investigate the current situation and characteristics of H6 AIVs circulating in China, we analysed the epidemiology, genetic evolution and patho…