Yan Ou
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View article: Investigation of Potential Biological Mechanisms Linking Blood Lipids and Head and Neck Squamous Cell Carcinoma
Investigation of Potential Biological Mechanisms Linking Blood Lipids and Head and Neck Squamous Cell Carcinoma Open
Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignancy with a heterogeneous etiology. Circulating total cholesterol (TC), apolipoprotein A-I (ApoA-I), and low-density lipoprotein cholesterol (LDL-C) may influence …
View article: Significantly higher incidence of circulating fatty objects in portal blood samples compared to peripheral blood samples in patients with pancreatic ductal adenocarcinoma
Significantly higher incidence of circulating fatty objects in portal blood samples compared to peripheral blood samples in patients with pancreatic ductal adenocarcinoma Open
Introduction We previously reported the identification of circulating fatty objects (CFOs), abnormal entities found in peripheral blood samples from cancer patients. CFOs are large spherical objects with high contents of heavy cholesterol …
View article: Molecular Predictors of Ritlecitinib Efficacy in Alopecia Areata: Role of JAK3-Dependent Inflammation and Follicular Integrity
Molecular Predictors of Ritlecitinib Efficacy in Alopecia Areata: Role of JAK3-Dependent Inflammation and Follicular Integrity Open
View article: Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022
Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022 Open
Tuberculosis (TB) is a serious respiratory disease posing significant public health threats, such as the variation in Mycobacterium tuberculosis ( M.tb ) lineages and their associated drug resistance across regions. In 2022, clinical data …
View article: Family Intensive Behavioral Intervention for Children with Autism Spectrum Disorder: A Half-Year Comparison-Controlled Study
Family Intensive Behavioral Intervention for Children with Autism Spectrum Disorder: A Half-Year Comparison-Controlled Study Open
Objective: Family intervention is a crucial component of treatment for children with autism spectrum disorder (ASD), yet the impact of parent-mediated family-intensive behavioral intervention on the language abilities of children with ASD …
View article: Fedtc: An Effective Federated Learning Approach to Alleviate Model Forgetting and Model Drifting for Gastritis Detection
Fedtc: An Effective Federated Learning Approach to Alleviate Model Forgetting and Model Drifting for Gastritis Detection Open
View article: Long‐Term Durability of Transcatheter Aortic Valve Prostheses in Patients With Bicuspid Versus Tricuspid Aortic Valve
Long‐Term Durability of Transcatheter Aortic Valve Prostheses in Patients With Bicuspid Versus Tricuspid Aortic Valve Open
Background Currently, there is a lack of evidence for the long‐term bioprosthetic valve durability of patients with bicuspid aortic valve (BAV) following transcatheter aortic valve replacement (TAVR). Methods and Results This study aimed t…
View article: Efficacy and safety of bismuth quadruple regimens containing minocycline and vonoprazan for eradication of <i>Helicobacter pylori</i>: Real‐world evidence
Efficacy and safety of bismuth quadruple regimens containing minocycline and vonoprazan for eradication of <i>Helicobacter pylori</i>: Real‐world evidence Open
Background and Aim To evaluate the efficacy and safety of minocycline, vonoprazan, amoxicillin, and bismuth quadruple therapy for Helicobacter pylori ( H. pylori ) treatment. Methods From August 2022 to May 2023, clinical data were collect…
View article: Supplementary Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells
Supplementary Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells Open
This file contains Supplementary Tables S1 and S2, and Figures S1 - S6.
View article: Supplementary Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells
Supplementary Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells Open
This file contains Supplementary Tables S1 and S2, and Figures S1 - S6.
View article: Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells
Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells Open
Cisplatin and tyrosine kinase inhibitors (TKI) are recommended to treat non–small cell lung cancer (NSCLC). However, ubiquitously acquired drug resistance in patients with NSCLC diminishes their therapeutic efficacy. Strategies for overcom…
View article: Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells
Data from Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells Open
Cisplatin and tyrosine kinase inhibitors (TKI) are recommended to treat non–small cell lung cancer (NSCLC). However, ubiquitously acquired drug resistance in patients with NSCLC diminishes their therapeutic efficacy. Strategies for overcom…
View article: Occamy: Elastically Sharing a SIMD Co-processor across Multiple CPU Cores
Occamy: Elastically Sharing a SIMD Co-processor across Multiple CPU Cores Open
SIMD extensions are widely adopted in multi-core processors to exploit data-level parallelism. However, when co-running workloads on different cores, compute-intensive workloads cannot take advantage of the underutilized SIMD lanes allocat…
View article: Meta-analysis of the regulatory effect of traditional Chinese medicine on intestinal flora in patients with constipation
Meta-analysis of the regulatory effect of traditional Chinese medicine on intestinal flora in patients with constipation Open
Objective: To systematically evaluate the regulatory effect of traditional Chinese medicine on intestinal flora in patients with constipation. Methods: From PubMed, Embase, Web of Science and Cochrane Library to December 2022, the qualifie…
View article: A case of rectal diverticulitis resembling a submucosal tumor under colorectal endoscopy: a hitherto undescribed lesion
A case of rectal diverticulitis resembling a submucosal tumor under colorectal endoscopy: a hitherto undescribed lesion Open
A 47-year-old man was referred to our hospital for a routine colorectal endoscopy health check-up. During the endoscopy, a submucosal tumor (SMT)-like lesion with a smooth mucosal surface, approximately 10 mm in diameter and with a top pin…
View article: Endoscopic removal of a migrated esophageal covered self-expandable metal stent: the nylon loop pusher-assisted method
Endoscopic removal of a migrated esophageal covered self-expandable metal stent: the nylon loop pusher-assisted method Open
Covered self-expandable metal stents (SEMSs) can migrate, with an incidence of more than 30 % [1]. Various techniques for removal of migrated SEMSs have been reported [2] [3] [4]. However, the nylon loop pusher-assisted approach for remova…
View article: Advances in Research on the Incidence, Risk and Treatment of Crohn’s Disease during Pregnancy
Advances in Research on the Incidence, Risk and Treatment of Crohn’s Disease during Pregnancy Open
Crohn's disease is an intestinal inflammatory disease of unknown cause, which is clinically divided into acute phase, subacute phase, and chronic phase.The disease symptoms can invade the entire digestive tract, and the most typical lesion…
View article: Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy
Association between regular arrangement of collecting venules and Helicobacter pylori status in routine endoscopy Open
View article: Light blue crest sign visualized by magnifying endoscopy in normal colonic mucosa
Light blue crest sign visualized by magnifying endoscopy in normal colonic mucosa Open
Light blue crest (LBC), defined as a fine, blue-white line on the crests of the epithelial surface/gyri, is always discerned at the edge of marginal crypt epithelium [1]. The optical sign has high specificity for the endoscopic identificat…
View article: Association Between Regular Arrangement of Collecting Venules and Helicobacter Pylori Status in Routine Endoscopy
Association Between Regular Arrangement of Collecting Venules and Helicobacter Pylori Status in Routine Endoscopy Open
Background: The sensitivity of regular arrangement of collecting venules (RAC)-positive pattern for predicting Helicobacter pylori (H. pylori)-negative status greatly altered from 93.8% to 48.0% in recent two decades of various studies, wh…
View article: Effect of uremic serum on Th17/Treg cell balance and endoplasmic reticulum stress in rats
Effect of uremic serum on Th17/Treg cell balance and endoplasmic reticulum stress in rats Open
Uremic serum can lead to the imbalance of Th17/Treg cells as well as ERS, suggesting that ERS is one of the mechanisms of the imbalance of Th17/Treg cells induced by uremic serum. Sodium citrate can inhibit ERS induced by uremic serum.
View article: Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats
Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats Open
Acute spinal cord injury (SCI) has a high rate of disability and mortality. Although secondary SCI results in local tissue hypoxia and the release of inflammatory mediators, it is both controllable and reversible. Therefore, timely rehabil…
View article: Correlation of increased Th17/Treg cell ratio with endoplasmic reticulum stress in chronic kidney disease
Correlation of increased Th17/Treg cell ratio with endoplasmic reticulum stress in chronic kidney disease Open
To investigate the relationship between the regulatory immune network and endoplasmic reticulum stress (ERS) in patients with different stages of chronic kidney disease (CKD).A total of 91 patients diagnosed with CKD were divided into diff…
View article: The Endothelial Nitric Oxide Synthase Gene Polymorphism is Associated with the Susceptibility to Immunoglobulin a Nephropathy in Chinese Population
The Endothelial Nitric Oxide Synthase Gene Polymorphism is Associated with the Susceptibility to Immunoglobulin a Nephropathy in Chinese Population Open
Background/Aims: Endothelial nitric oxide synthase (eNOS) is one of the most important enzymes for producting nitric oxide (NO), which regulate the function of many organs and cells. The single nucleotide polymorphisms (SNPs)…
View article: Sorafenib Ameliorates Renal Fibrosis through Inhibition of TGF-β-Induced Epithelial-Mesenchymal Transition
Sorafenib Ameliorates Renal Fibrosis through Inhibition of TGF-β-Induced Epithelial-Mesenchymal Transition Open
Our results suggest that sorafenib may useful for the treatment of renal fibrosis through the suppression of TGF-β/Smad3-induced EMT signaling.
View article: Inhibition of Urinary Macromolecule Heparin on Aggregation of Nano-COM and Nano-COD Crystals
Inhibition of Urinary Macromolecule Heparin on Aggregation of Nano-COM and Nano-COD Crystals Open
Purpose: This research aims to study the influences of heparin (HP) on the aggregation of nano calcium oxalate monohydrate (COM) and nano calcium oxalate dihydrate (COD) with mean diameter of about 50 nm. Method: The influences of differen…
View article: Supplementary Material for: Sodium Citrate Inhibits Endoplasmic Reticulum Stress in Rats with Adenine-Induced Chronic Renal Failure
Supplementary Material for: Sodium Citrate Inhibits Endoplasmic Reticulum Stress in Rats with Adenine-Induced Chronic Renal Failure Open
Background/Aims: Endoplasmic reticulum stress (ERS) is an important self-protective cellular response to harmful stimuli that contribute to various diseases, including chronic renal failure (CRF). Sodium citrate plays an impo…