Chia Soo
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View article: Gender-specific differences in embolic risk of infective endocarditis
Gender-specific differences in embolic risk of infective endocarditis Open
Background Embolic events are a severe complication of infective endocarditis (IE). Understanding the role of sex differences in embolic risk and the associated predictors may improve patient stratification and management. Methods A total …
View article: Gender differences in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance feature tracking
Gender differences in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance feature tracking Open
Introduction The recognition of gender differences in cardiovascular disease is increasing. Cardiac magnetic resonance imaging (CMR) offers high spatial and temporal resolution images irrespective of body shape and size. This enables preci…
View article: Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight
Specific host metabolite and gut microbiome alterations are associated with bone loss during spaceflight Open
Understanding the axis of the human microbiome and physiological homeostasis is an essential task in managing deep-space-travel-associated health risks. The NASA-led Rodent Research 5 mission enabled an ancillary investigation of the gut m…
View article: A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery
A novel injectable fibromodulin‐releasing granular hydrogel for tendon healing and functional recovery Open
A crucial component of the musculoskeletal system, the tendon is one of the most commonly injured tissues in the body. In severe cases, the ruptured tendon leads to permanent dysfunction. Although many efforts have been devoted to seeking …
View article: Additional file 1 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
Additional file 1 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight Open
Additional file 1. Complete list of DGE genes in the gastrocnemius. 120 genes were significantly differentially expressed across spaceflight in the gastrocnemius. Reported here are the gene symbol, log2 fold change (log2 FC), and FDR-adjus…
View article: Additional file 4 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
Additional file 4 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight Open
Additional file 4. Complete list of DAS events in the quadriceps. 285 DAS events in 180 genes were identified across spaceflight in the quadriceps. Reported here are the gene symbol, event type (SE, skipped exon; MXE, mutually exclusive ex…
View article: Additional file 5 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
Additional file 5 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight Open
Additional file 5. Gene ontology analyses. Enrichment by gene ontology of upregulated (first), downregulated (second), and alternatively spliced (third) genes in the gastrocnemius (left column) and quadriceps (right column). Reported here …
View article: Additional file 2 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight
Additional file 2 of Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight Open
Additional file 2. Complete list of DGE genes in the quadriceps. 70 genes were significantly differentially expressed across spaceflight in the quadriceps. Reported here are the gene symbol, log2 fold change (log2 FC), and FDR-adjusted p-v…
View article: Alternative splicing regulates the physiological adaptation of the mouse hind limb postural and phasic muscles to microgravity
Alternative splicing regulates the physiological adaptation of the mouse hind limb postural and phasic muscles to microgravity Open
Muscle atrophy and fiber type alterations are well-characterized physiological adaptations to microgravity with both understood to be primarily regulated by differential gene expression (DGE). While microgravity-induced DGE has been extens…
View article: Physiological electric fields induce directional migration of mammalian cranial neural crest cells
Physiological electric fields induce directional migration of mammalian cranial neural crest cells Open
During neurulation, cranial neural crest cells (CNCCs) migrate long distances from the neural tube to their terminal site of differentiation. The pathway traveled by the CNCCs defines the blueprint for craniofacial construction, abnormalit…
View article: Photopolymerizable Hydrogel-Encapsulated Fibromodulin-Reprogrammed Cells for Muscle Regeneration
Photopolymerizable Hydrogel-Encapsulated Fibromodulin-Reprogrammed Cells for Muscle Regeneration Open
A central challenge in tissue engineering is obtaining a suitable cell type with a capable delivery vehicle to replace or repair damaged or diseased tissues with tissue mimics. Notably, for skeletal muscle tissue engineering, given the ina…
View article: Nell-1 Is a Key Functional Modulator in Osteochondrogenesis and Beyond
Nell-1 Is a Key Functional Modulator in Osteochondrogenesis and Beyond Open
Neural EGFL-like 1 (Nell-1) is a well-studied osteogenic factor that has comparable osteogenic potency with the Food and Drug Administration–approved bone morphogenic protein 2 (BMP-2). In this review, which aims to summarize the advanced …
View article: CDKN2B upregulation prevents teratoma formation in multipotent fibromodulin-reprogrammed cells
CDKN2B upregulation prevents teratoma formation in multipotent fibromodulin-reprogrammed cells Open
Tumorigenicity is a well-documented risk to overcome for pluripotent or multipotent cell applications in regenerative medicine. To address the emerging demand for safe cell sources in tissue regeneration, we established a novel, protein-ba…
View article: Abstract 74: Inactivation of Cntnap4 in Cranial Neural Crest Cells Results in Craniofacial Bone Deformities and Hydrocephalus
Abstract 74: Inactivation of Cntnap4 in Cranial Neural Crest Cells Results in Craniofacial Bone Deformities and Hydrocephalus Open
PURPOSE: Contactin-associated protein-like 4 (Cntnap4) is a member of the neurexin superfamily of transmembrane molecules that have critical functions in neuronal cell communication. For example, global Cntnap4 knockout mice exhibit autism…
View article: Abstract QS40: A Novel Bioactive Suture That Accelerates Wound Tensile Strength Re-establishment And Enhances Wound Healing
Abstract QS40: A Novel Bioactive Suture That Accelerates Wound Tensile Strength Re-establishment And Enhances Wound Healing Open
PURPOSE: Sutures are essential medical devices for tissue approximation to achieve wound healing. Unfortunately, conventional sutures only serve as passive bystanders as they are limited to mechanical approximation, but not biological acti…
View article: Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis
Inactivation of Nell-1 in Chondrocytes Significantly Impedes Appendicular Skeletogenesis Open
NELL-1, an osteoinductive protein, has been shown to regulate skeletal ossification. Interestingly, an interstitial 11p14.1-p15.3 deletion involving the Nell-1 gene was recently reported in a patient with short stature and delayed fontanel…
View article: Current development of biodegradable polymeric materials for biomedical applications
Current development of biodegradable polymeric materials for biomedical applications Open
In the last half-century, the development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable polymeric materials are favored in the development of therapeutic devices, including tempo…