Explanipedia

Circulating exosomes in sepsis induce PD-1 expression in macrophages and promote Th17 differentiation Open

Shao‐Chun Wu, Yi-Chan Wu, Chia-Wei Lin, Tsu‐Hsiang Lu, Ming‐Yu Yang , et al. · 2025

Background: Sepsis induces complex immunological responses; however, the role of circulating exosomes in regulating macrophage function and T cell responses remains unknown. This study examined the effects of sepsis-derived exosomes on mac…

The Genetic Role of Matrix Metalloproteinase-12 in Determining Childhood Acute Lymphocytic Leukemia Risk Open

CHAO-CHUN CHEN, JEN-SHENG PEI, Huey‐En Tzeng, Pei‐Chen Hsu, Te‐Chun Hsia , et al. · 2025

While MMP-12 rs2276109 and rs652438 polymorphisms do not appear to affect susceptibility to childhood ALL, rs652438 variant genotypes may serve as prognostic biomarkers for disease severity and outcome. Further functional validation…

Single-cell transcriptomic analysis reveals therapeutic mechanisms of adipose-derived stem cell exosomes in sepsis-induced lung injury Open

Shao‐Chun Wu, Cheng‐Shyuan Rau, Yi-Chan Wu, Chia-Wei Lin, Tsu‐Hsiang Lu , et al. · 2025

Background: Sepsis-induced acute lung injury remains a leading cause of mortality in critically ill patients, with limited effective treatments beyond supportive care. This study investigates the therapeutic efficacy and underlying mechani…

Contribution of MRE11, RAD50, and NBS1 Genotypes to Bladder Cancer Susceptibility Open

CHENG-HSI LIAO, Wen-Shin Chang, HOU-YU SHIH, YUN-CHI WANG, Che-Lun Hsu , et al. · 2025

NBS1 rs2735383 genotype may serve as a genetic biomarker for BLCA susceptibility, particularly in high-risk subpopulations, including elders, smokers, drinkers, and those with muscle-invasive disease.

Tracking adipose-derived stem cell exosomes applied in a mouse crush injury model: insights from fluorescent labeling and spatial transcriptomics – an experimental study Open

Cheng‐Shyuan Rau, Shao‐Chun Wu, Pao‐Jen Kuo, Chia-Wei Lin, Tsu‐Hsiang Lu , et al. · 2024

Adipose-derived stem cell exosomes (ADSC-exos) are promising for nerve regeneration; however, their precise mechanisms remain unclear. This study employed fluorescent labeling and spatial transcriptomics to track the effects of ADSC-exos o…

Characterizing Genetic Susceptibility to Colorectal Cancer in Taiwan Through Genome‐Wide Association Study Open

Da‐Tian Bau, Ting‐Yuan Liu, Jai‐Sing Yang, William Tzu‐Liang Chen, Chia‐Wen Tsai , et al. · 2024

We conducted the first genome‐wide association study (GWAS) of colorectal cancer (CRC) in Taiwan with 5342 cases and 61,015 controls. Ninety‐two SNPs in three genomic regions reached genome‐wide significance ( p < 5 × 10 −8 ). The lead SNP…

Impacts of Interleukin-10 Promoter Genotypes on Prostate Cancer Open

YU-TING CHIN, Chung-Lin Tsai, Hung-Huan Ma, Da‐Chuan Cheng, Chia‐Wen Tsai , et al. · 2024

Prostate cancer (PCa) is a multifactorial disease influenced by genetic, environmental, and immunological factors. Genetic polymorphisms in the interleukin-10 (IL-10) gene have been implicated in PCa susceptibility, development, and progre…

Effects of carnosic acid on mitochondrial biogenesis and insulin sensitivity in 3T3-L1 adipocytes are through induction of PGC-1α and ubiquitination of PARIS by parkin Open

Chia‐Yuan Lin, Yun-Hsin Cheng, Chiao-Ni Lai, Chia‐Wen Tsai · 2023

The PGC-1α plays a vital role in regulating mitochondrial biogenesis and insulin sensitivity. This study investigated the role of PGC-1α in preventing the effects of carnosic acid (CA) against TNF-α-suppressed mitochondrial biogenesis and …

Impact of Mir196a-2 Genotypes on Colorectal Cancer Risk in Taiwan Open

TE-CHENG YUEH, YUN-CHI WANG, Yu‐Ting Chin, Yi‐Chih Hung, Mei‐Chin Mong , et al. · 2023

We aimed to investigate the association between genotypes for mir146a and mir196a-2 and the risk of developing colorectal cancer (CRC). We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the …

The effects of online peer-facilitated learning and distributed pair programming on students’ learning Open

Chia‐Wen Tsai, Michael Yu-Ching Lin, Yih-Ping Cheng, Lan-Yu Lee, Wen-Li Chyr , et al. · 2023

Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis Open

Chih-Wun Fang, Jai‐Sing Yang, Jo‐Hua Chiang, Pochuen Shieh, Fuu‐Jen Tsai , et al. · 2023

Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. Howev…

Impacts of Mir146a Genotypes on Bladder Cancer Risk in Taiwan Open

Bo-Ren Wang, WEN-SHIN CHANG, Cheng-Hsi Liao, YUN-CHI WANG, Jian Gu , et al. · 2023

The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in mir146a and mir196a and bladder cancer (BLCA) risk in Taiwan. The genotypes of mir146a rs2910164 and mir196a rs11614913 were determi…

Integrating online meta-cognitive learning strategy and team regulation to develop students’ programming skills, academic motivation, and refusal self-efficacy of Internet use in a cloud classroom Open

Chia‐Wen Tsai, Lan-Yu Lee, Yih-Ping Cheng, Chih-Hsien Lin, Min‐Ling Hung , et al. · 2022

Role of Matrix Metallopeptidase-2 Genotypes in Taiwanese Patients With Colorectal Cancer Open

TE-CHENG YUEH, Yi‐Chih Hung, Hsu‐Tung Lee, Mei‐Due Yang, Zhihong Wang , et al. · 2022

The MMP2 -1306 genotype serves as a novel predictive marker for CRC risk among Taiwanese, and patients who have a tendency to undergo metastasis.

The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes to Hepatocellular Carcinoma Susceptibility Open

TE-CHENG YUEH, HAO-YUAN TSAO, WEI-CHING CHIEN, Chia‐Wen Tsai, JEN-SHENG PEI , et al. · 2022

Metalloproteinase-7 (MMP-7) has been previously found to be up-regulated in hepatocellular carcinoma (HCC) specimens and cells, favoring epithelial-mesenchymal transition. However, the contribution of MMP-7 genotypes to HCC has not been re…

Significant Contribution of Interleukin-18 Genotypes to Childhood Acute Lymphocytic Leukemia Risk in Taiwanese Open

Chao‐Chun Chen, Huey‐En Tzeng, Chien‐Chung Kuo, S. NGERN SAE LIM, Pei‐Chen Hsu , et al. · 2022

IL-18 rs187238 GC and CC genotypes can serve as predictors for childhood ALL prognosis among Taiwanese. Validation in larger and various populations can greatly extend the feasibility of this novel predictor.

Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion Open

Shu-Er Yang, Jin‐Cherng Lien, Chia‐Wen Tsai, Chi‐Rei Wu · 2022

Isoflavones have been widely studied and have attracted extensive attention in fields ranging from chemotaxonomy and plant physiology to human nutrition and medicine. Isoflavones are often divided into three subgroups: simple O-substituted…

A new technique for separating platelet-rich plasma by a copolymer device － without a centrifugation process Open

Lien‐Hung Huang, Cheng‐Shyuan Rau, Wen-Hong Zeng, Tsu‐Hsiang Lu, Yi-Chan Wu , et al. · 2022

Based on these results, we developed a cationic copolymer-coated PU sponge as a PRP preparation device without the need for any centrifugation.

Impacts of mir146a genotypes to bladder cancer risk in Taiwan Open

WEN-SHIN CHANG, Cheng-Hsi Liao, Chao‐Hsuan Chen, Boren Wang, Zhihong Wang , et al. · 2022

We aimed to examine the associations of the genotypes for mir146a and mir196a with bladder cancer (BLCA) risk in Taiwan. Mir146a rs2910164 and mir196a rs11614913 genotypes among 375 bladder cancer patients and 375 healthy subjects were det…

Book Review Open

Chia‐Wen Tsai, Pei‐Di Shen, Yi‐Chun Chiang · 2022

In recent years, wearable and mobile technologies have been applied in different domains such as medical, personal safety, sports, and lifestyle computing (Cheng & Mitomo, 2017). Wearable technologies may help users bring their experiences…

Impact of Premium and Price Cuts on Consumer Purchase Intention Open

Yi‐Fen Chen, Chia‐Wen Tsai, Priscilia Vanessa Kuswanto · 2022

This study aims to compare the price cut and premium promotion with study moderators are discount depth size, product type, premium characteristics, and country effect (Indonesia and Taiwan). The experiment was designed as: (promotional di…

The Effects of Facebook Live-Stream Teaching on Improving Students' Dance Skills Open

Chien-Chih Wu, Hsiao-Wen Chao, Chia‐Wen Tsai · 2021

The purpose of this study is to enhance the effect of dance skill learning, learning motivation, and physical activity class satisfaction. Moreover, the outcome of these quasi-experiments illustrate the effects of Facebook Live-stream teac…

Identification and characterization of hADSC‐derived exosome proteins from different isolation methods Open

Lien‐Hung Huang, Cheng‐Shyuan Rau, Shao‐Chun Wu, Yi‐Chan Wu, Chia‐Jung Wu , et al. · 2021

Exosomes are secreted into the extracellular space by most cell types and contain various molecular constituents, which play roles in many biological processes. Adipose‐derived mesenchymal stem cells (ADSCs) can differentiate into a variet…

Leukocyte Telomere Length Is Associated with Aggressive Prostate Cancer in Localized Prostate Cancer Patients Open

Junfeng Xu, WEN-SHIN CHANG, Chia‐Wen Tsai, Da‐Tian Bau, Yifan Xu , et al. · 2019

The applications of augmented reality for universal access in online education Open

Chia‐Wen Tsai · 2017

Exploring the Effects of Online Academic Help-Seeking and Flipped Learning on Improving Students' Learning. Open

Wen-Li Chyr, Pei‐Di Shen, Yi‐Chun Chiang, Jau-Bi Lin, Chia‐Wen Tsai · 2017

Introduction The needs for online academic help-seeking and flipped learning Over the past two decades, teaching and learning processes have been influenced by technological, instructional and pedagogical advances (Chou & Tsai, 2002; Kavan…

Applications of social networking for universal access in online learning environments Open

Chia‐Wen Tsai · 2016

Research Papers in Online Learning Performance and Behaviour Open

Chia‐Wen Tsai · 2016

Successful learning requires that students be motivated to achieve the desired learning goals (Lee, & Hao, 2015).However, not all students can develop an effective path that is beneficial to learning on their own (Lee, Cheng, Rai, & Depick…

Stone weirs in Penghu and adaption to tourism development Open

Shyi-Liang Yu, Ying-Chien Chu, Chia‐Wen Tsai · 2015

The ancient fishing methods include stone fish weir, beach seine and baulk net, but the fish catches of the stone fish weir is the most abundant. The stone fish weirs not only constitute important landscape, but also are representative of …

Chia‐Wen Tsai YOU? Author Swipe