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HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors. Open

Hiroyuki Kato, Hidetoshi Sumimoto, Philippe Pognonec, C H Chen, C A Rosen , et al. · 1992

The HIV-1 trans-activator Tat increases the rate of transcription from the HIV-1 LTR promoter through the stem-loop-containing TAR RNA. To analyze the mechanisms of Tat action, a cell-free trans-activation system with no preincubation has …

A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. Open

Sophie Roy, Ulrike Delling, C H Chen, C A Rosen, Nahum Sonenberg · 1990

The Tat protein of human immunodeficiency virus type 1 (HIV-1) trans-activates viral gene expression and is obligatory for virus replication. Tat function is mediated through a sequence termed TAR that comprises part of the 5'-noncoding re…