Wei‐Chiao Chang
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View article: Novel precision-cut lung slice immune co-culture models to study macrophage and fibroblast interactions in pulmonary fibrosis 3481
Novel precision-cut lung slice immune co-culture models to study macrophage and fibroblast interactions in pulmonary fibrosis 3481 Open
Description Precision-cut lung slices (PCLS) are widely used ex vivo models for studying lung fibrosis but traditionally lack immune cell infiltration, which is critical for understanding inflammation and fibrosis. To address this limitati…
View article: Comparison of depression risk and depression-related ambulatory care utilization in sarcopenia patients with and without Chinese herbal medicine
Comparison of depression risk and depression-related ambulatory care utilization in sarcopenia patients with and without Chinese herbal medicine Open
BACKGROUND The impact of psychiatric disorder, especially depression, on the prognosis of sarcopenic patients is gaining prominence. Yet, there have been very few studies focusing on this issue, let alone the related targeted mental health…
View article: Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity
Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity Open
Background Research comprehensively examining factors for COVID-19 DNA vaccine responses is lacking, particularly in Asian populations. This study aims to investigate biomarkers of reactogenic and immunogenic responses after DNA-based COVI…
View article: Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts
Whole exome sequencing and polygenic risk assessment for kidney functions and clinical management in both hospital-based cohort and population-based Asian cohorts Open
View article: 388. COMMON AND DISTINCT EFFECTS OF 10-HZ RTMS AND ITBS ON STRIATUM-BASED FUNCTIONAL CONNECTIVITY IN MAJOR DEPRESSIVE DISORDER: A SHAM-CONTROLLED STUDY
388. COMMON AND DISTINCT EFFECTS OF 10-HZ RTMS AND ITBS ON STRIATUM-BASED FUNCTIONAL CONNECTIVITY IN MAJOR DEPRESSIVE DISORDER: A SHAM-CONTROLLED STUDY Open
Background Abnormalities in the prefrontal cortex (PFC)-related network play an important role in the pathophysiology of major depressive disorder (MDD). Accumulating evidence indicated that fronto-striatal dysconnectivity is critical to M…
View article: Comprehensive analysis of B cell receptor repertoires reveals a distinct lambda light chain landscape in immunoglobulin A nephropathy
Comprehensive analysis of B cell receptor repertoires reveals a distinct lambda light chain landscape in immunoglobulin A nephropathy Open
These findings indicated significantly distinct features of BCR light chain repertoire in IgAN patients and suggested that characteristics of BCR light chain repertoire are very likely as potential biomarkers for the diagnosis of IgAN.
View article: Evaluating the cost-effectiveness of atezolizumab-bevacizumab in advanced hepatocellular carcinoma: Insights from Taiwan
Evaluating the cost-effectiveness of atezolizumab-bevacizumab in advanced hepatocellular carcinoma: Insights from Taiwan Open
Following the observed significant improvements in overall survival and progression-free survival in clinical trials, the combination of atezolizumab and bevacizumab has been recommended as a first-line therapy for patients with unresectab…
View article: The association between mammography reports and women’s age using retrospective data form a medical system
The association between mammography reports and women’s age using retrospective data form a medical system Open
Objective We explored the association of age, obesity and marital status with Breast Imaging Reporting and Data System (BI-RADS) category distribution in women, using retrospective mammography data from a medical system, as only a few stud…
View article: Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing
Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing Open
Background Type 2 diabetes is an increasingly prevalent metabolic disorder with moderate to high heritability. Glycemic indices are crucial for diagnosing and monitoring the disease. Previous genome-wide association study (GWAS) have ident…
View article: Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA
Characterization of binding affinity changes of SARS-CoV-2 omicron variant peptides to population-specific HLA Open
View article: Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation
Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation Open
Fire‐related smoke inhalation‐induced acute lung injury (SI‐ALI) is a prevalent condition in modern fires, characterized by high mortality and a lack of targeted therapeutic options. Previous research has been hindered by instability in sm…
View article: Microstructure control during cryogenic 3D printing to obtain biomimetic porous and tough cross-scale mineralized collagen bone scaffold
Microstructure control during cryogenic 3D printing to obtain biomimetic porous and tough cross-scale mineralized collagen bone scaffold Open
Tissue engineering (TE) is a promising strategy to repair large bone defects by inducing endogenous bone regeneration. The ideal bone TE scaffold should possess high porosity (90%), suitable stiffness (1 MPa), and most importantly, a compo…
View article: Cryogenic 3D printing of damage tolerant hierarchical porous ceramics
Cryogenic 3D printing of damage tolerant hierarchical porous ceramics Open
Fabricating damage tolerant porous ceramics with efficient energy absorption and impact-resistant capability has been a challenge because of the brittle nature of ceramic materials. In nature, mineralized tissues or organisms such as cuttl…
View article: Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities
Genome-wide association study of the fatty liver index in the Taiwanese population reveals shared and population-specific genetic risk factors across ethnicities Open
View article: Cost-effectiveness analysis of pembrolizumab with chemotherapy for metastatic nonsquamous non-small cell lung cancer in Taiwan
Cost-effectiveness analysis of pembrolizumab with chemotherapy for metastatic nonsquamous non-small cell lung cancer in Taiwan Open
This study was aimed to evaluate the cost-effectiveness of pembrolizumab with chemotherapy (pembrolizumab combination therapy) and compare it with standard-of-care platinum-based chemotherapy (chemotherapy alone) as a first-line treatment …
View article: Dietary contributions in the genetic variation of liver fibrosis: a genome-wide association study of fibrosis-4 index in the liver fibrosis development
Dietary contributions in the genetic variation of liver fibrosis: a genome-wide association study of fibrosis-4 index in the liver fibrosis development Open
Background The fibrosis-4 (FIB-4) index is a non-invasive method to assess the severity of liver fibrosis. The development of liver fibrosis is influenced by genetic predisposition and dietary factors. However, the modulating effect of die…
View article: Systemic toxicity of CAR-T therapy and potential monitoring indicators for toxicity prevention
Systemic toxicity of CAR-T therapy and potential monitoring indicators for toxicity prevention Open
Malignant tumors of the hematologic system have a high degree of malignancy and high mortality rates. Chimeric antigen receptor T cell (CAR-T) therapy has become an important option for patients with relapsed/refractory tumors, showing ast…
View article: A case report and literature review on TP53 gene mutation in a bladder rhabdomyosarcoma patient
A case report and literature review on TP53 gene mutation in a bladder rhabdomyosarcoma patient Open
Background Rhabdomyosarcoma of the bladder is an infrequent neoplastic condition characterized by a pronounced malignant situation with challenges in treatment due to the lack of standardized guidelines and large-scale of clinical studies.…
View article: A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy
A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy Open
Renal cell carcinoma (RCC) is considered radio- and chemo-resistant. Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical efficacy in advanced RCC. However, the overall response rate of RCC to monotherapy remains limi…
View article: Dynamic decline of lymphocytes predicts extracorporeal membrane oxygenation-related infections: a retrospective observational study
Dynamic decline of lymphocytes predicts extracorporeal membrane oxygenation-related infections: a retrospective observational study Open
Patients supported by ECMO had a high risk of developing ECMO-related infection. The most common ECMO-related infection observed was VAP. A dynamic decrease in lymphocyte counts was significantly associated with an increased risk of ECMO-r…
View article: Does the nurse-led case management benefit rheumatoid arthritis patients in reducing distressing symptoms and C-reactive protein: a 2-year follow-up study in Taiwan
Does the nurse-led case management benefit rheumatoid arthritis patients in reducing distressing symptoms and C-reactive protein: a 2-year follow-up study in Taiwan Open
Background Rheumatoid arthritis (RA) is a chronic disease and may worsen over time. Today, nurse-led case management (NLCM) has been recommended to improve clinical outcomes for chronic disease patients, yet little is known regarding its i…
View article: Characterization of the genetic variation and evolutionary divergence of the CLEC18 family
Characterization of the genetic variation and evolutionary divergence of the CLEC18 family Open
View article: Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population
Phenomic landscape and pharmacogenomic implications for HLA region in a Taiwan Han Chinese population Open
View article: CircMLH3 induces mononuclear macrophage pyroptosis in sepsis by sponging miR-590-3p to regulate TAK1 expression
CircMLH3 induces mononuclear macrophage pyroptosis in sepsis by sponging miR-590-3p to regulate TAK1 expression Open
Sepsis is a fatal syndrome characterized by uncontrolled systemic inflammatory responses. Circular RNAs (circRNAs) are involved in the modulation of various pathophysiological processes, but their potential role in sepsis has largely been …
View article: Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy
Characterization of T-Cell receptor repertoire in immunoglobulin a nephropathy Open
Immunoglobulin A nephropathy (IgAN) is an autoimmune disease characterized by abnormal IgA deposition in glomerulus. Current diagnosis of IgAN still depends on renal biopsy, an invasive method that might increase the risk of clinical outco…
View article: Triptolide Reduces Neoplastic Progression in Hepatocellular Carcinoma by Downregulating the Lipid Lipase Signaling Pathway
Triptolide Reduces Neoplastic Progression in Hepatocellular Carcinoma by Downregulating the Lipid Lipase Signaling Pathway Open
Hepatocellular carcinoma (HCC), which is the third leading cause of cancer-related mortality in the world, presents a significant medical challenge. Triptolide (TP) has been identified as an effective therapeutic drug for HCC. However, its…
View article: Investigation of LAG3 and PD1 in Melanoma Through Integrative Analysis of TCGA and GEO Data
Investigation of LAG3 and PD1 in Melanoma Through Integrative Analysis of TCGA and GEO Data Open
Lymphocyte activation gene-3 (LAG3) has become a promising therapeutic target in cancer immunotherapy. This study aims to determine the synergistic effect of anti-LAG3 and anti-PD1 against melanoma and identify new potential targets for me…
View article: Using echocardiography based deep learning to early detect the infarct related artery in patients with acute coronary syndrome
Using echocardiography based deep learning to early detect the infarct related artery in patients with acute coronary syndrome Open
Funding Acknowledgements Type of funding sources: None. Background In patients with acute coronary syndrome (ACS), echocardiography detected regional wall motion abnormalities (RWMA) facilitates the recognition of ischemic heart disease an…
View article: Genetic alterations in peritoneal metastatic tumors predicted the outcomes for hyperthermic intraperitoneal chemotherapy
Genetic alterations in peritoneal metastatic tumors predicted the outcomes for hyperthermic intraperitoneal chemotherapy Open
Introduction Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are considered for patients with peritoneal metastasis (PM). However, patients selection that relies on conventional prognostic factors is not y…
View article: Current Trends in Neoantigen-Based Cancer Vaccines
Current Trends in Neoantigen-Based Cancer Vaccines Open
Cancer immunotherapies are treatments that use drugs or cells to activate patients’ own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as …