Chiara Brombin
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View article: Preparedness for the Digital Transition in Healthcare: Insights from an Italian Sample of Professionals
Preparedness for the Digital Transition in Healthcare: Insights from an Italian Sample of Professionals Open
Background: The digital transition is reshaping healthcare systems through the adoption of telemedicine and electronic health records (EHRs). While these innovations enhance efficiency and access, their implementation unfolds within overst…
View article: Comprehensive one-day management of prostate cancer patients: PRO-FAST single-fraction ablative, urethral-sparing, HDR-like, robotic SBRT
Comprehensive one-day management of prostate cancer patients: PRO-FAST single-fraction ablative, urethral-sparing, HDR-like, robotic SBRT Open
The study was prospectively registered at clinicaltrials.gov (NCT05936736).
View article: Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells
Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells Open
Gene editing (GE) using homology-directed repair (HDR) in hematopoietic stem and progenitor cells (HSPCs) offers promise for long-range gene correction of inherited genetic disorders. However, cellular responses induced by CRISPR-Cas9/AAV6…
View article: In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking Open
Lentiviral vector (LV)-mediated ex vivo gene therapy for haematopoietic stem and progenitor cells (HSPCs) has delivered on the promise of a 'one-and-done' treatment for several genetic diseases1. However, ex vivo manipulation an…
View article: Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes
Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes Open
In vivo gene therapy to the liver using lentiviral vectors (LV) may represent a one-and-done therapeutic approach for monogenic diseases. Increasing LV gene therapy potency is crucial for reducing the effective doses, thus alleviating dose…
View article: 18F-FDG PET/CT guided salvage radiotherapy strategies for lymph-nodal relapses in gynecological cancers: SBRT vs ENRT
18F-FDG PET/CT guided salvage radiotherapy strategies for lymph-nodal relapses in gynecological cancers: SBRT vs ENRT Open
Objective: To identify outcome differences between extended nodal radiotherapy (ENRT) with simultaneous integrated boost (SIB) and stereotactic body radiotherapy (SBRT), performed with advanced radiotherapy techniques, both of which were 1…
View article: 52P Tumor-targeted cytokine release by genetically-engineered myeloid cells rescues CAR-T activity and engages endogenous T cells against high-grade glioma in mouse models
52P Tumor-targeted cytokine release by genetically-engineered myeloid cells rescues CAR-T activity and engages endogenous T cells against high-grade glioma in mouse models Open
View article: Spectral dynamics prior to motor events differ between NREM sleep parasomnias and healthy sleepers
Spectral dynamics prior to motor events differ between NREM sleep parasomnias and healthy sleepers Open
Study Objectives The umbrella term “Disorders of Arousal” (DoA), encompassing sleepwalking, confusional arousals, and sleep terrors, refers to parasomnias manifesting during nonrapid eye movement (NREM) sleep, commonly thought to arise fro…
View article: Comparing fundraising campaigns in healthcare using psychophysiological data: a network-based approach
Comparing fundraising campaigns in healthcare using psychophysiological data: a network-based approach Open
View article: Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia
Immune signature in vaccinated versus non-vaccinated aged people with COVID-19 pneumonia Open
Background A definition of the immunological features of COVID-19 pneumonia is needed to support clinical management of aged patients. In this study, we characterized the humoral and cellular immune responses in presence or absence of SARS…
View article: Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency Open
Recombination activating genes ( RAGs ) are tightly regulated during lymphoid differentiation, and their mutations cause a spectrum of severe immunological disorders. Hematopoietic stem and progenitor cell (HSPC) transplantation is the tre…
View article: Author Correction: Genotoxic effects of base and prime editing in human hematopoietic stem cells
Author Correction: Genotoxic effects of base and prime editing in human hematopoietic stem cells Open
In the version of the article initially published, there were errors in Fig. 4d
View article: Extended Nodal Radiotherapy for Prostate Cancer Lymph-Nodal Relapse Guided with [11C]-Choline PET/CT: ten-year results in patients enrolled in a prospective trial
Extended Nodal Radiotherapy for Prostate Cancer Lymph-Nodal Relapse Guided with [11C]-Choline PET/CT: ten-year results in patients enrolled in a prospective trial Open
View article: Genotoxic effects of base and prime editing in human hematopoietic stem cells
Genotoxic effects of base and prime editing in human hematopoietic stem cells Open
View article: P1373: UNCOVERING UPSIDES AND PITFALLS OF BASE AND PRIME EDITING IN HEMATOPOIETIC STEM CELLS
P1373: UNCOVERING UPSIDES AND PITFALLS OF BASE AND PRIME EDITING IN HEMATOPOIETIC STEM CELLS Open
Topic: 24. Gene therapy, cellular immunotherapy and vaccination - Biology & Translational Research Background: Emerging base and prime editing (BE/PE) may provide safer and more precise genetic engineering than nuclease-based approaches by…
View article: S255: CELLULAR SENESCENCE AND INFLAMMATORY PROGRAMS ARE UNINTENDED CONSEQUENCES OF CRISPR-CAS9 GENE EDITING IN HEMATOPOIETIC STEM AND PROGENITOR CELLS
S255: CELLULAR SENESCENCE AND INFLAMMATORY PROGRAMS ARE UNINTENDED CONSEQUENCES OF CRISPR-CAS9 GENE EDITING IN HEMATOPOIETIC STEM AND PROGENITOR CELLS Open
Topic: 24. Gene therapy, cellular immunotherapy and vaccination - Biology & Translational Research Background: Gene editing (GE) in hematopoietic stem and progenitor cells (HSPCs) is a revolutionary site-specific gene correction strategy f…
View article: Analysis of healthcare workers’ mental health during the COVID-19 pandemic: Evidence from a three-wave longitudinal study
Analysis of healthcare workers’ mental health during the COVID-19 pandemic: Evidence from a three-wave longitudinal study Open
The “Healthcare workers’ wellbeing [Benessere Operatori]” project is an exploratory longitudinal study assessing healthcare workers’ mental health at three different time points over a 14-month period during the COVID-19 pandemic. We colle…
View article: Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include Supplementary Figure Legends
View article: Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include more detailed Material and Methods
View article: Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically…
View article: Supplementary Figures S1-7 and Tables S1-2 from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Figures S1-7 and Tables S1-2 from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include Supplementary Figures S1-7 and Tables S1-2. Figure S1. Inflammation and neo-angiogenesis are not impaired in TPA-treated uPAR-/- skin. Figure S2. Distinct stages of hair cycling in uPAR+/+ and uPAR-/- littermates. Figure …
View article: Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
The urokinase-type plasminogen activator receptor (uPAR) has a well-established role in cancer progression, but it has been little studied at earlier stages of cancer initiation. Here, we show that uPAR deficiency in the mouse dramatically…
View article: Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Figure Legends from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include Supplementary Figure Legends
View article: Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Data from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include more detailed Material and Methods
View article: Supplementary Figures S1-7 and Tables S1-2 from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1
Supplementary Figures S1-7 and Tables S1-2 from Urokinase Receptor Promotes Skin Tumor Formation by Preventing Epithelial Cell Activation of Notch1 Open
This file include Supplementary Figures S1-7 and Tables S1-2. Figure S1. Inflammation and neo-angiogenesis are not impaired in TPA-treated uPAR-/- skin. Figure S2. Distinct stages of hair cycling in uPAR+/+ and uPAR-/- littermates. Figure …
View article: Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models
Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models Open
This paper is based on a retrospective longitudinal study on people living with HIV under antiretroviral treatment (ART) where allelic variants (either heterozygous CT genotype or homozygous CC genotype) have been evaluated at position −16…
View article: Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells Open
View article: Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates Open
Liver gene therapy with adeno-associated viral (AAV) vectors delivering clotting factor transgenes into hepatocytes has shown multiyear therapeutic benefit in adults with hemophilia. However, the mostly episomal nature of AAV vectors chall…
View article: The “Healthcare Workers’ Wellbeing [Benessere Operatori]” Project: A Longitudinal Evaluation of Psychological Responses of Italian Healthcare Workers during the COVID-19 Pandemic
The “Healthcare Workers’ Wellbeing [Benessere Operatori]” Project: A Longitudinal Evaluation of Psychological Responses of Italian Healthcare Workers during the COVID-19 Pandemic Open
Background: COVID-19 forced healthcare workers to work in unprecedented and critical circumstances, exacerbating already-problematic and stressful working conditions. The “Healthcare workers’ wellbeing (Benessere Operatori)” project aimed …
View article: Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 Infection
Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 Infection Open
This contribution explores in a new statistical perspective the antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 141 coronavirus disease 2019 (COVID-19) patients exhibiting a broad range of clinical man…