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View article: Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors
Antineoplastic Activity of a Novel Trispecific Single-Chain Antibody Targeting the hERG1/β1 Integrin Complex and TRAIL Receptors Open
Targeted therapies and immunotherapies have largely improved cancer treatment in the last years. One of the most promising approaches is the induction of tumor apoptosis by TRAIL through its binding to apoptosis-inducing receptors DR4 and …
View article: An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer.
An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer. Open
Reciprocal signaling between the Tumor Microenvironment (TME) and cancer cells regulates abnormal proliferation, migration and pro-metastatic behavior. Major player in such interaction is integrin-mediated cell adhesion to the Extracellula…
View article: Ion channels in lung cancer: biological and clinical relevance
Ion channels in lung cancer: biological and clinical relevance Open
Despite improvements in treatment, lung cancer is still a major health problem worldwide. Among lung cancer subtypes, the most frequent is represented by adenocarcinoma (belonging to the Non-Small Cell Lung Cancer class) although the most …
View article: Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex
Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex Open
Introduction: In the last decades, mounting evidence has pointed out the human ether-á-go-go–related gene (hERG1) potassium channel as a novel biomarker in human cancers. However, hERG1 sustains the cardiac repolarizing current IKr and its…
View article: Video S1C from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1C from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Supplementary Materials and Methods, Supplementary Figure 1-8 from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Supplementary Materials and Methods, Supplementary Figure 1-8 from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Supplementary Table S1 shows nucleotide sequence of the scDb-hERG1-β1. Supplementary Table S2 reports a list of primers. Supplementary Figure S1 dot blot and Coomassie staining of different scDb-hERG1-β1 clones. Supplementary Figure S2 sho…
View article: Video S1C from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1C from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Data from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Data from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
mAbs, either mono- or bispecific (bsAb), represent one of the most successful approaches to treat many types of malignancies. However, there are certain limitations to the use of full length mAbs for clinical applications, which can be ove…
View article: Video S1B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Video S2A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S2A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of 8mg/kg of scDb
View article: Supplementary Materials and Methods, Supplementary Figure 1-8 from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Supplementary Materials and Methods, Supplementary Figure 1-8 from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Supplementary Table S1 shows nucleotide sequence of the scDb-hERG1-β1. Supplementary Table S2 reports a list of primers. Supplementary Figure S1 dot blot and Coomassie staining of different scDb-hERG1-β1 clones. Supplementary Figure S2 sho…
View article: Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of 8mg/kg of scDb
View article: Video S2A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S2A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of 8mg/kg of scDb
View article: Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of 8mg/kg of scDb
View article: Video S1D from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1D from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Video S1A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Video S1D from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1D from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of 8mg/kg of scDb
View article: Video S1A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1A from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Video S1B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S1B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of saline solution (CTRL)
View article: Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Video S2B from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
Non Linear Contrast Mode imaging of mouse kidneys 3 hours after the injection of 8mg/kg of scDb
View article: Data from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Data from Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
mAbs, either mono- or bispecific (bsAb), represent one of the most successful approaches to treat many types of malignancies. However, there are certain limitations to the use of full length mAbs for clinical applications, which can be ove…
View article: Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers
Harnessing the hERG1/β1 Integrin Complex via a Novel Bispecific Single-chain Antibody: An Effective Strategy against Solid Cancers Open
mAbs, either mono- or bispecific (bsAb), represent one of the most successful approaches to treat many types of malignancies. However, there are certain limitations to the use of full length mAbs for clinical applications, which can be ove…