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View article: Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting
Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting Open
Steroidogenesis of gonadal cells is tightly regulated by gonadotropins. However, certain polycyclic aromatic hydrocarbons, including Benzo[a]pyrene (BaP), induce reproductive toxicity. Several existing studies have considered higher than e…
View article: Short-Term Exposure to Bisphenol A Does Not Impact Gonadal Cell Steroidogenesis In Vitro
Short-Term Exposure to Bisphenol A Does Not Impact Gonadal Cell Steroidogenesis In Vitro Open
Bisphenol A (BPA) is a ubiquitous, synthetic chemical proven to induce reproductive disorders in both men and women. The available studies investigated the effects of BPA on male and female steroidogenesis following long-term exposure to t…
View article: Interplay of spermatogonial subpopulations during initial stages of spermatogenesis in adult primates
Interplay of spermatogonial subpopulations during initial stages of spermatogenesis in adult primates Open
The spermatogonial compartment maintains spermatogenesis throughout the reproductive lifespan. Single-cell RNA sequencing (scRNA-seq) has revealed the presence of several spermatogonial clusters characterized by specific molecular signatur…
View article: cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor
cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor Open
Cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) signaling pathway is the master regulator of endocrine tissue function. The level, compartmentalization and amplitude of cAMP response are finely regulated by phosphodiesterases (P…
View article: The activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma
The activation of M2 muscarinic receptor inhibits cell growth and survival in human epithelial ovarian carcinoma Open
Ovarian cancer is the fifth leading cause of cancer‐related deaths in females. Many ovarian tumor cell lines express muscarinic receptors (mAChRs), and their expression is correlated with reduced survival of patients. We have characterized…
View article: TNF‐α inhibits GDNF levels in Sertoli cells, through a NF‐κB‐dependent, HES1‐dependent mechanism
TNF‐α inhibits GDNF levels in Sertoli cells, through a NF‐κB‐dependent, HES1‐dependent mechanism Open
Background Glial cell line‐derived neurotrophic factor (GDNF) is a soluble molecule crucial for the regulation of the spermatogonial stem cells (SSC) of the testis. The effects of GDNF on target cells have been extensively described, but m…
View article: Regulation of <i>Gdnf</i> expression by retinoic acid in Sertoli cells
Regulation of <i>Gdnf</i> expression by retinoic acid in Sertoli cells Open
Glial cell line‐derived neurotrophic factor (GDNF) and retinoic acid (RA) are two molecules crucial for the regulation of the spermatogonial compartment of the testis. During the cycle of the seminiferous epithelium, their relative concent…
View article: Information system for the management of the Archaeological Map of Macerata province: the map of archaeological potential as an tool for the management of the archaeological heritage and territorial planning of the inner areas.
Information system for the management of the Archaeological Map of Macerata province: the map of archaeological potential as an tool for the management of the archaeological heritage and territorial planning of the inner areas. Open
The research is aimed at creating a map of archaeological risk and a map of archaeological potential for the province of Macerata. The exam of the data of the Archaeological Map of Macerata province highlights different degrees of informat…