Chiara Casella
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View article: Reducing motion artefact in high resolution 7T MRI using the Magnetic Resonance Minimal Motion (‘MR-MinMo’) head stabilisation device
Reducing motion artefact in high resolution 7T MRI using the Magnetic Resonance Minimal Motion (‘MR-MinMo’) head stabilisation device Open
Purpose To evaluate the effectiveness of the MR-MinMo head stabilisation device in mitigating motion artifacts during long-duration, high-resolution 7T MRI scans, with and without retrospective motion correction. Methods The MR-MinMo was t…
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Author response: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
Author response: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Ultra-High Field 7T MRI in a Drug-Resistant Pediatric Epilepsy Cohort
Ultra-High Field 7T MRI in a Drug-Resistant Pediatric Epilepsy Cohort Open
7T MRI in children with epilepsy is well tolerated and associated with a 23% improvement in lesion detection, directly affecting clinical management and surgical outcomes. Although limited by a preselected cohort with extensive diagnostic …
View article: MiniMORPH: A Morphometry Pipeline for Low-Field MRI in Infants
MiniMORPH: A Morphometry Pipeline for Low-Field MRI in Infants Open
Background Ultra-low-field (ULF) MRI facilitates neuroimaging access, yet its application in early infancy is constrained by low resolution/contrast, and the limited suitability of existing segmentation tools. Objective We present miniMORP…
View article: Feasibility and Validity of Ultra- Low-Field MRI for Measurement of Regional Infant Brain Volumes in Structures Associated with Antenatal Maternal Anemia
Feasibility and Validity of Ultra- Low-Field MRI for Measurement of Regional Infant Brain Volumes in Structures Associated with Antenatal Maternal Anemia Open
Introduction The availability of ultra- low-field (ULF) magnetic resonance imaging (MRI) has the potential to improve neuroimaging accessibility in low-resource settings. However, the utility of ULF MRI in detecting child brain changes ass…
View article: Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis
Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis Open
Purpose This study aimed to validate a retrospective motion correction technique, Distributed and Incoherent Sample Orders for Reconstruction Deblurring using Encoding Redundancy (DISORDER), for pediatric brain morphometry. Methods Two T1-…
View article: In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging
In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging Open
Background Huntington’s Disease (HD) is an inherited neurodegenerative disorder characterised by progressive cognitive and motor decline due to atrophy in basal ganglia networks. No disease-modifying therapies exist, but novel clinical tri…
View article: Quantitative T1 and Effective Proton Density (PD*) mapping in children and adults at 7T from an MP2RAGE sequence optimised for uniform T1-weighted (UNI) and FLuid And White matter Suppression (FLAWS) contrasts
Quantitative T1 and Effective Proton Density (PD*) mapping in children and adults at 7T from an MP2RAGE sequence optimised for uniform T1-weighted (UNI) and FLuid And White matter Suppression (FLAWS) contrasts Open
Quantitative T1 and PD mapping is important for non-invasive tissue characterisation. Here, we aimed to calculate effective proton density (PD*) and quantitative T1 relaxation maps at 7T using the MP2RAGE sequence and an analytical formula…
View article: High-Field 7T MRI in a drug-resistant paediatric epilepsy cohort: image comparison and radiological outcomes
High-Field 7T MRI in a drug-resistant paediatric epilepsy cohort: image comparison and radiological outcomes Open
Background and Objectives Epileptogenic lesions in focal epilepsy can be subtle or undetected on conventional brain MRI. Ultra-high field (7T) MRI offers higher spatial resolution, contrast and signal-to-noise ratio compared to conventiona…
View article: Quantitative T1 and Effective Proton Density (PD*) mapping in children and adults at 7T from an MP2RAGE sequence optimised for uniform T1-weighted (UNI) and FLuid And White matter Suppression (FLAWS) contrasts
Quantitative T1 and Effective Proton Density (PD*) mapping in children and adults at 7T from an MP2RAGE sequence optimised for uniform T1-weighted (UNI) and FLuid And White matter Suppression (FLAWS) contrasts Open
Introduction Quantitative MRI is important for non-invasive tissue characterisation. In previous work we developed a clinically feasible multi-contrast protocol for T 1 -weighted imaging based on the MP2RAGE sequence that was optimised for…
View article: High resolution and contrast 7 tesla MR brain imaging of the neonate
High resolution and contrast 7 tesla MR brain imaging of the neonate Open
Introduction Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved pathological and anatomical sensitivity. These benefits are particularly relevant for the n…
View article: Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy
Widespread, depth‐dependent cortical microstructure alterations in pediatric focal epilepsy Open
Objective Tissue abnormalities in focal epilepsy may extend beyond the presumed focus. The underlying pathophysiology of these broader changes is unclear, and it is not known whether they result from ongoing disease processes or treatment‐…
View article: Differences in white matter detected by<i>ex vivo</i>9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease
Differences in white matter detected by<i>ex vivo</i>9.4T MRI are associated with axonal changes in the R6/1 model of Huntington’s Disease Open
White matter (WM) volume loss has been reported in people with Huntington’s disease (HD), but the cellular basis of this deficit remains to be elucidated. To address this, we assessed ex vivo WM microstructure in the transgenic R6/1 mouse …
View article: Exploration of the potential of high resolution and contrast 7 Tesla MR brain imaging in neonates
Exploration of the potential of high resolution and contrast 7 Tesla MR brain imaging in neonates Open
BACKGROUND Ultra-high field MR imaging offers marked gains in signal-to-noise ratio, spatial resolution, and contrast which translate to improved sensitivity for pathology and anatomy. These benefits are particularly relevant for the neona…
View article: Widespread, depth-dependent cortical microstructure alterations in paediatric focal epilepsy
Widespread, depth-dependent cortical microstructure alterations in paediatric focal epilepsy Open
Objective Tissue abnormalities in focal epilepsy may extend beyond the presumed focus. The underlying pathophysiology of these broader changes is unclear, and it is not known whether they result from ongoing disease processes, treatment-re…
View article: Simultaneous Optimization of <scp>MP2RAGE T<sub>1</sub></scp>‐weighted (<scp>UNI</scp>) and FLuid And White matter Suppression (<scp>FLAWS</scp>) brain images at <scp>7T</scp> using Extended Phase Graph (<scp>EPG</scp>) Simulations
Simultaneous Optimization of <span>MP2RAGE T<sub>1</sub></span>‐weighted (<span>UNI</span>) and FLuid And White matter Suppression (<span>FLAWS</span>) brain images at <span>7T</span> using Extended Phase Graph (<span>EPG</span>) Simulations Open
Purpose The MP2RAGE sequence is typically optimized for either T 1 ‐weighted uniform image (UNI) or gray matter–dominant fluid and white matter suppression (FLAWS) contrast images. Here, the purpose was to optimize an MP2RAGE protocol at 7…
View article: Mutation‐related magnetization‐transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra‐strong gradient <scp>MRI</scp>
Mutation‐related magnetization‐transfer, not axon density, drives white matter differences in premanifest Huntington disease: Evidence from in vivo ultra‐strong gradient <span>MRI</span> Open
White matter (WM) alterations have been observed in Huntington disease (HD) but their role in the disease‐pathophysiology remains unknown. We assessed WM changes in premanifest HD by exploiting ultra‐strong‐gradient magnetic resonance imag…
View article: Subiculum–BNST structural connectivity in humans and macaques
Subiculum–BNST structural connectivity in humans and macaques Open
View article: Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington’s disease: Evidence from <i>in vivo</i> ultra-strong gradient MRI
Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington’s disease: Evidence from <i>in vivo</i> ultra-strong gradient MRI Open
White matter (WM) alterations have been observed early in Huntington’s disease (HD) progression but their role in the disease-pathophysiology remains unknown. We exploited ultra-strong-gradient MRI to tease apart contributions of myelin (w…
View article: Subiculum – BNST Structural Connectivity in Humans and Macaques
Subiculum – BNST Structural Connectivity in Humans and Macaques Open
Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituita…
View article: E05 Mutation-related apparent myelin, not axon density, drives white matter pathology in premanifest huntington’s disease: evidence from in vivo ultra-strong gradient MRI
E05 Mutation-related apparent myelin, not axon density, drives white matter pathology in premanifest huntington’s disease: evidence from in vivo ultra-strong gradient MRI Open
Background White matter (WM) impairments precede striatal atrophy and motor symptoms in Huntington's disease (HD) but their aetiology remains unknown. Aims We exploited ultra-strong gradient MRI to disentangle the contribution of changes i…
View article: Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington’s disease
Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington’s disease Open
White matter (WM) alterations have been identified as a relevant pathological feature of Huntington’s disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin-associated biological proces…
View article: Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease
Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease Open
White matter (WM) alterations have been identified as a relevant pathological feature of Huntington's disease (HD). Increasing evidence suggests that WM changes in this disorder are due to alterations in myelin-associated biological proces…
View article: Drumming Motor Sequence Training Induces Apparent Myelin Remodelling in Huntington’s Disease: A Longitudinal Diffusion MRI and Quantitative Magnetization Transfer Study
Drumming Motor Sequence Training Induces Apparent Myelin Remodelling in Huntington’s Disease: A Longitudinal Diffusion MRI and Quantitative Magnetization Transfer Study Open
Background: Impaired myelination may contribute to Huntington’s disease (HD) pathogenesis. Objective: This study assessed differences in white matter (WM) microstructure between HD patients and controls, and tested whether drumming trainin…
View article: A Critical Review of White Matter Changes in Huntington’s Disease
A Critical Review of White Matter Changes in Huntington’s Disease Open
Huntington’s disease is a genetic neurodegenerative disorder. White matter alterations have recently been identified as a relevant pathophysiological feature of Huntington’s disease, but their etiology and role in disease pathogenesis and …
View article: Drumming motor sequence training induces apparent myelin remodelling in Huntington’s disease: a longitudinal diffusion MRI and quantitative magnetization transfer study
Drumming motor sequence training induces apparent myelin remodelling in Huntington’s disease: a longitudinal diffusion MRI and quantitative magnetization transfer study Open
1. Abstract Background Impaired myelination may contribute to Huntington’s disease (HD) pathogenesis. This study assessed differences in white matter (WM) microstructure between HD patients and controls, and tested whether drumming trainin…