Chiara E. Cotroneo
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View article: Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain
Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain Open
Lanthipeptides are a large group of ribosomally encoded peptides cyclized by thioether and methylene bridges, which include the lantibiotics, lanthipeptides with antimicrobial activity. There are over 100 experimentally characterized lanth…
View article: Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue
Genetic predisposition to lung adenocarcinoma outcome is a feature already present in patients' noninvolved lung tissue Open
Emerging evidence suggests that the prognosis of patients with lung adenocarcinoma can be determined from germline variants and transcript levels in nontumoral lung tissue. Gene expression data from noninvolved lung tissue of 483 lung aden…
View article: Computational modelling of chromosomally clustering protein domains in bacteria
Computational modelling of chromosomally clustering protein domains in bacteria Open
Background In bacteria, genes with related functions—such as those involved in the metabolism of the same compound or in infection processes—are often physically close on the genome and form groups called clusters. The enrichment of such c…
View article: Computational modelling of Chromosomally Clustering Protein Domains In Bacteria
Computational modelling of Chromosomally Clustering Protein Domains In Bacteria Open
Background: In bacteria, genes with related functions - such as those involved in the metabolism of the same compound or in infection processes - are often physically close on the genome and form groups called clusters. The enrichment of s…
View article: prokaryotes_filtered.txt
prokaryotes_filtered.txt Open
14,178 genomes selected from those available at NCBI Genbank Genomes database https://ftp.ncbi.nlm.nih.gov/genomes/genbank/ for analysis in the paper "Computational modelling of chromosomally clustering protein domains in bacteria". These …
View article: Lung expression of genes encoding SARS-CoV-2 cell entry molecules and antiviral restriction factors: interindividual differences are associated with age and germline variants
Lung expression of genes encoding SARS-CoV-2 cell entry molecules and antiviral restriction factors: interindividual differences are associated with age and germline variants Open
Germline variants in genes involved in SARS-CoV-2 cell entry (i.e. ACE2 and TMPRSS2 ) may influence the susceptibility to infection, as may polymorphisms in genes involved in the innate host response to viruses (e.g. APOBEC3 family). We se…
View article: Complex genetic control of lung tumorigenesis in resistant mice strains
Complex genetic control of lung tumorigenesis in resistant mice strains Open
The SM /J mouse strain is resistant to chemically‐induced lung tumorigenesis despite having a haplotype, in the pulmonary adenoma susceptibility locus ( Pas1 ) locus, that confers tumor susceptibility in other strains. To clarify this inco…
View article: Human Lung Tissue Transcriptome: Influence of Sex and Age
Human Lung Tissue Transcriptome: Influence of Sex and Age Open
Gene expression in non-tumor lung tissue is modulated by both sex and age. These findings represent a validated starting point for research on the molecular mechanisms underlying the observed differences in the course of lung diseases amon…
View article: DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus
DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus Open
Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans, but relatively little is known about the global regulation of virulence factors during infection of chickens or humans. This study identified DNA supercoilin…
View article: Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma
Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma Open
Read-through transcripts result from the continuous transcription of adjacent, similarly oriented genes, with the splicing out of the intergenic region. They have been found in several neoplastic and normal tissues, but their pathophysiolo…