Chiara Fedeli
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View article: Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC)
Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC) Open
Background The global mpox outbreak that started in May 2022 was caused by a novel clade IIb variant of the mpox virus (Orthopoxvirus monkeypox, MPXV). It differed from the traditional Western and Central Africa disease in transmission pat…
View article: A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover
A novel circulating tamiami mammarenavirus shows potential for zoonotic spillover Open
A detailed understanding of the mechanisms underlying the capacity of a virus to break the species barrier is crucial for pathogen surveillance and control. New World (NW) mammarenaviruses constitute a diverse group of rodent-borne pathoge…
View article: The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry
The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry Open
The zoonotic Old World mammarenavirus Lassa (LASV) causes severe hemorrhagic fever with high mortality and morbidity in humans in endemic regions. The development of effective strategies to combat LASV infections is of high priority, given…
View article: A novel cell‐based sensor detecting the activity of individual basic proprotein convertases
A novel cell‐based sensor detecting the activity of individual basic proprotein convertases Open
The basic proprotein convertases (PCs) furin, PC1/3, PC2, PC5/6, PACE4, PC4, and PC7 are promising drug targets for human diseases. However, developing selective inhibitors remains challenging due to overlapping substrate recognition motif…
View article: Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses
Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses Open
New World (NW) arenaviruses are a diverse family of emerging zoonotic viruses that merit significant attention as important public health problems. The close genetic relationship of nonpathogenic NW arenaviruses with their highly pathogeni…
View article: Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus
Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus Open
Recognition of cellular receptors allows emerging viruses to break species barriers and is an important determinant for their disease potential. Many virus receptors have complex tissue-specific interactomes, and preexisting protein-protei…
View article: PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca<sup>2+</sup> homeostasis
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca<sup>2+</sup> homeostasis Open
PSEN2 (presenilin 2) is one of the 3 proteins that, when mutated, causes early onset familial Alzheimer disease (FAD) cases. In addition to its well-known role within the γ-secretase complex (the enzyme ultimately responsible for Aβ peptid…
View article: Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion
Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion Open
Emerging human-pathogenic arenaviruses are causative agents of severe hemorrhagic fevers with high mortality and represent serious public health problems. The current lack of a licensed vaccine and the limited treatment options makes the d…
View article: A novel cell-based sensor detecting the activity of individual basic proprotein convertases
A novel cell-based sensor detecting the activity of individual basic proprotein convertases Open
The basic proprotein convertases (PCs) furin, PC1/3, PC2, PC5/6, PACE4, PC4, and PC7 are promising drug targets for human diseases. However, developing selective inhibitors remains challenging due to overlapping substrate recognition motif…
View article: C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes
C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes Open
Poly(2-methyl-2-oxazoline) (PMOXA) is an alternative promising polymer to poly(ethylene glycol) (PEG) for design and engineering of macrophage-evading nanoparticles (NPs). Although PMOXA-engineered NPs have shown comparable pharmacokinetic…
View article: Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan
Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan Open
Fatal infection with the highly pathogenic Lassa virus (LASV) is characterized by extensive viral dissemination, indicating broad tissue tropism. The major cellular receptor for LASV is the highly conserved extracellular matrix receptor dy…
View article: [F3–06–02]: ALTERATIONS IN ER‐MITOCHONDRIA CALCIUM TRANSFER INDUCED BY ALZHEIMER's DISEASE‐LINKED PS2 MUTANTS IMPACT DIFFERENT CELL FUNCTIONALITIES
[F3–06–02]: ALTERATIONS IN ER‐MITOCHONDRIA CALCIUM TRANSFER INDUCED BY ALZHEIMER's DISEASE‐LINKED PS2 MUTANTS IMPACT DIFFERENT CELL FUNCTIONALITIES Open
The privileged physical connection between ER and mitochondria plays an important role in fundamental cellular processes, such as maintenance of Ca2+ and lipid homeostasis, regulation of autophagy and life-or-death decisions. We previously…
View article: Formyl-Peptide Receptor Agonists and Amorphous SiO<sub>2</sub>-NPs Synergistically and Selectively Increase the Inflammatory Responses of Human Monocytes and PMNs
Formyl-Peptide Receptor Agonists and Amorphous SiO<sub>2</sub>-NPs Synergistically and Selectively Increase the Inflammatory Responses of Human Monocytes and PMNs Open
We tested whether amorphous SiO 2 -NPs and formylpeptide receptor (FPRs) agonists synergistically activate human monocytes and neutrophil polymorphonuclear granulocytes (PMNs). Peptide ligands specifically binding to FPR1 (f-MLP) and to FP…
View article: The functional dissection of the plasma corona of SiO<sub>2</sub>-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages
The functional dissection of the plasma corona of SiO<sub>2</sub>-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages Open
One protein, histidine rich glycoprotein, prevails in the corona of SiO2-NPs in excess human plasma and interferes with macrophage capture.