Chiara Nosarti
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View article: Perinatal environmental exposures, maternal mental health and cognitive outcomes in very preterm infants born in urban London
Perinatal environmental exposures, maternal mental health and cognitive outcomes in very preterm infants born in urban London Open
Perinatal environmental exposures have distinct effects on maternal-infant outcomes. Neurotoxicant exposure and limited access to restorative environments may negatively impact early neurodevelopment, while noise reduction may support mate…
View article: C-reactive protein levels and behavioural outcomes in mid-childhood in very preterm and term born children
C-reactive protein levels and behavioural outcomes in mid-childhood in very preterm and term born children Open
We show no evidence that prematurity or perinatal inflammation are associated with salivary CRP in mid-childhood, nor that perinatal inflammatory insults are related to later behavioural outcomes in our cohort of preterm children. Our find…
View article: A scoping review exploring the needs, barriers, and facilitators to the collection of biological data in adolescence for mental health research.
A scoping review exploring the needs, barriers, and facilitators to the collection of biological data in adolescence for mental health research. Open
Background: There is increasing recognition of the challenge of representativeness in data, including economic, social, and ethnic diversity, in biological mental health research. This is a particular challenge in adolescence, where brain …
View article: Associations Between Neonatal Brain Structure and Neurodevelopmental Outcomes Following Very Preterm Birth
Associations Between Neonatal Brain Structure and Neurodevelopmental Outcomes Following Very Preterm Birth Open
BackgroundVery preterm (VPT) children have high risks of neurodevelopmental delays, yet early predictors for specific impairments are poorly understood. This study investigated how neonatal brain structure relates to neurodevelopmental del…
View article: Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis
Verifying the concordance between motion corrected and conventional MPRAGE for pediatric morphometric analysis Open
Purpose This study aimed to validate a retrospective motion correction technique, Distributed and Incoherent Sample Orders for Reconstruction Deblurring using Encoding Redundancy (DISORDER), for pediatric brain morphometry. Methods Two T1-…
View article: Socioeconomic outcomes in very preterm/very low birth weight adults: individual participant data meta-analysis
Socioeconomic outcomes in very preterm/very low birth weight adults: individual participant data meta-analysis Open
Background Very preterm (VPT; <32 weeks) or very low birth weight (VLBW; <1500 g) birth is associated with socioeconomic disadvantages in adulthood; however, the predictors of these outcomes remain underexplored. This study examined socioe…
View article: Fertility of young adults born very preterm/very low birth weight: An individual participant data meta-analysis
Fertility of young adults born very preterm/very low birth weight: An individual participant data meta-analysis Open
VP/VLBW is not associated with lower fertility in young adults. Sex does not moderate this association. In addition to childhood neurosensory impairment, mainly sociodemographic factors (partnering, maternal and own education) are associat…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the nonlinear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been comp…
View article: Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction
Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction Open
Fetal growth restriction (FGR) subjects exhibit altered metabolism, with higher metabolic rate due to their small body mass, and by adopting strategies to minimise energy expenditure. We investigated how these metabolic differences develop…
View article: Association and shared biological bases between birth weight and cortical structure
Association and shared biological bases between birth weight and cortical structure Open
Associations between birth weight and cortical structural phenotypes have been detected; however, the understanding is incomprehensive, and the potential biological bases are not well defined. Leveraging data from genome-wide association s…
View article: Gestational age at birth and cognitive outcomes in term-born children: Evidence from Chinese and British cohorts
Gestational age at birth and cognitive outcomes in term-born children: Evidence from Chinese and British cohorts Open
Older GA in term-born toddlers is associated with more favourable developmental outcomes across different cultural contexts.
View article: <i>In vivo</i> tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity
<i>In vivo</i> tractography of human neonatal white-matter pathways underlying hypothalamic and reward functions to study predispositions to neurodevelopmental conditions and obesity Open
White matter (WM) tracts of the reward, limbic, and autonomic systems implicate the hypothalamus, nucleus accumbens, ventral tegmental area and the amygdala and are associated with autism, ADHD, addiction and obesity. However, since most o…
View article: Being Born Early Can Affect the Way We Control Our Emotions
Being Born Early Can Affect the Way We Control Our Emotions Open
Every year, 13 million babies are born before the usual 9 months of pregnancy. To understand what happens to these babies’ brains when they grow up, we used powerful brain scans to take detailed photos of the brain, and we compared the bra…
View article: Exploring functional connectivity in clinical and data-driven groups of preterm and term adults
Exploring functional connectivity in clinical and data-driven groups of preterm and term adults Open
Adults born very preterm (i.e. at <33 weeks’ gestation) are more susceptible to long-lasting structural and functional brain alterations and cognitive and socio-emotional difficulties, compared with full-term controls. However, behaviou…
View article: Early predictors of late childhood behavioural outcomes following very preterm birth
Early predictors of late childhood behavioural outcomes following very preterm birth Open
Background Children born very preterm (VPT; ≤32 weeks’ gestation) are at higher risk of developing behavioural problems, encompassing socio-emotional processing and attention, compared to term-born children. This study aimed to examine mul…
View article: Environmental variables influence the relationship between maternal depressive symptoms and toddlers' neurocognitive and affective outcomes
Environmental variables influence the relationship between maternal depressive symptoms and toddlers' neurocognitive and affective outcomes Open
Motherhood is often associated with joy, but it can pose significant challenges, and in some instances lead to perinatal mental health problems. Maternal depressive symptoms can hinder a mother's ability to attune to her infant's needs, po…
View article: The Developing Human Connectome Project: A fast deep learning-based pipeline for neonatal cortical surface reconstruction
The Developing Human Connectome Project: A fast deep learning-based pipeline for neonatal cortical surface reconstruction Open
The Developing Human Connectome Project (dHCP) aims to explore developmental patterns of the human brain during the perinatal period. An automated processing pipeline has been developed to extract high-quality cortical surfaces from struct…
View article: “Does facial emotion recognition mediate the relationship between preterm birth and social skills? – A meta-analysis”
“Does facial emotion recognition mediate the relationship between preterm birth and social skills? – A meta-analysis” Open
FER might play a crucial role in the social development of PB individuals compared to those born at term, but existing research in this domain remains limited.
View article: Association between Higher Intake of Flavonols and Lignans and Better Mood: Evidence from Dietary and Biomarker Evaluation in Healthy Individuals
Association between Higher Intake of Flavonols and Lignans and Better Mood: Evidence from Dietary and Biomarker Evaluation in Healthy Individuals Open
Scope The aim of this study is to investigate associations between (poly)phenol consumption, circulating (poly)phenol metabolites, and mood states in healthy individuals. Methods and results The study included 333 healthy individuals. Mood…
View article: Romantic and sexual relationships of young adults born very preterm: An individual participant data meta‐analysis
Romantic and sexual relationships of young adults born very preterm: An individual participant data meta‐analysis Open
Aim To compare romantic and sexual relationships between adults born very preterm (VP; <32 weeks of gestation) or with very low birth weight (VLBW; <1500 g) and at term, and to evaluate potential biological and environmental explanatory fa…
View article: Cortical scaling of the neonatal brain in typical and altered development
Cortical scaling of the neonatal brain in typical and altered development Open
Theoretically derived scaling laws capture the non-linear relationships between rapidly expanding brain volume and cortical gyrification across mammalian species and in adult humans. However, the preservation of these laws has not been com…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies Open
BACKGROUND: Hypoxic Ischemic Encephalopathy (HIE) is a signifi cant cause of perinatal encephalopathy, affecting a substantial number of neonates.Therapeutic hypothermia (TH) has become a standard treatment, signifi cantly reducing mortali…
View article: Exploring the research needs, barriers and facilitators to the collection of biological data in adolescence for mental health research: a scoping review protocol paper
Exploring the research needs, barriers and facilitators to the collection of biological data in adolescence for mental health research: a scoping review protocol paper Open
Introduction While research into adolescent mental health has developed a considerable understanding of environmental and psychosocial risk factors, equivalent biological evidence is lacking and is not representative of economic, social an…
View article: The Developing Human Connectome Project: A Fast Deep Learning-based Pipeline for Neonatal Cortical Surface Reconstruction
The Developing Human Connectome Project: A Fast Deep Learning-based Pipeline for Neonatal Cortical Surface Reconstruction Open
The Developing Human Connectome Project (dHCP) aims to explore developmental patterns of the human brain during the perinatal period. An automated processing pipeline has been developed to extract high-quality cortical surfaces from struct…
View article: Attentional development is altered in toddlers with congenital heart disease
Attentional development is altered in toddlers with congenital heart disease Open
Background Congenital Heart Disease (CHD) is the most common congenital abnormality. Survival rates are over 90%, however infants with CHD remain at high risk of attention and executive function impairments. These abilities are difficult t…
View article: Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers
Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers Open
Identifying factors linked to autism traits in the general population may improve our understanding of the mechanisms underlying divergent neurodevelopment. In this study we assess whether factors increasing the likelihood of childhood aut…