Explanipedia

Vaccination coverage among adolescent athletes: Patterns, gaps, and implications for sports medicine Open

Klara Komici, Silvio Tafuri, Chiara Noviello, Fabio D’Amico, Ludovico Persichini , et al. · 2025

Physical activity is fundamental for health. However, it could expose even young and healthy individuals to infections which can be prevented through vaccinations. We aimed to evaluate the vaccination status in a population of adolescent a…

Gender disparities in COVID-19 vaccine hesitancy in high-income countries: an umbrella review protocol Open

Christian J. Wiedermann, Chiara Noviello, Claudia Palmieri, Pasquale Stefanizzi, Giuliano Piccoliori , et al. · 2025

Introduction Vaccine hesitancy remains a critical public health challenge, especially in high-income countries. Gender differences in vaccine hesitancy can significantly affect vaccination rates and public health outcomes. The aim of this …

Off-label use of recombinant adjuvanted Herpes Zoster vaccine in a 10-year-old high-risk patient affected by epidermolysis bullosa: A case report Open

Claudia Palmieri, Chiara Noviello, Lorenza Moscara, Pasquale Stefanizzi, Irene Berti , et al. · 2025

Epidermolysis bullosa is a rare genetic disorder characterized by skin fragility and blistering, resulting from mutations in dermal-epidermal junction structural proteins. Disease severity varies, with some cases involving extensive skin d…

Inflammation in cancer cachexia: still the central tenet or just another player? Open

Noemi Iaia, Chiara Noviello, Maurizio Muscaritoli, Paola Costelli · 2025

Cancer cachexia, a multifactorial syndrome characterized by body weight loss, muscle, and adipose tissue wasting, affects patients with cancer. Over time, the definition of cachexia has been modified, including inflammation as one of the m…

Building evidences in Public Health Emergency Preparedness (“BePHEP” Project)—a systematic review Open

Michelangelo Mercogliano, Gloria Spatari, Chiara Noviello, Francesca Di Serafino, M. Mormile , et al. · 2025

Increasing vaccination coverage among healthcare workers: Active call and mandatory laws. Data from a large general hospital in Southern Italy Open

Pasquale Stefanizzi, Antonio Di Lorenzo, Luca Capodiferro, Lorenza Moscara, Chiara Noviello , et al. · 2024

Influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are respiratory pathogens which significantly impact healthcare systems. Seasonal vaccination is recommended for all healthcare workers (HCWs) to reduce the risk fo…

The ESG Determinants of Mental Health Index Across Italian Regions A Machine Learning Approach Open

Emanuela Resta, Giancarlo Logroscino, Silvio Tafuri, Preethymol Peter, Chiara Noviello , et al. · 2024

The following article analyses the relationship between the mental health index and the variables of the Environment, Social and Governance-ESG model in the Italian regions between 2004 and 2023. First of all, a static analysis is proposed…

The ESG Determinants of Mental Health Index Across Italian Regions: A Machine Learning Approach Open

Emanuela Resta, Giancarlo Logroscino, Silvio Tafuri, Preethymol Peter, Chiara Noviello , et al. · 2024

The following article analyses the relationship between the mental health index and the variables of the Environment, Social and Governance-ESG model in the Italian regions between 2004 and 2023. First of all, a static analysis is proposed…

The Mental Health Index across the Italian Regions in the ESG Context Open

Emanuela Resta, Giancarlo Logroscino, Silvio Tafuri, Preethymol Peter, Chiara Noviello , et al. · 2024

The following article analyses the relationship between the mental health index and the variables of the Environment, Social and Governance-ESG model in the Italian regions between 2004 and 2023.The econometric analysis is aimed at investi…

Therapeutic approach based on GDF5 to counteract age-related muscle wasting Fundamental Myology Muscle function Open

France Piétri‐Rouxel, Massiré Traoré, Chiara Noviello, Christel Gentil, M. Julien , et al. · 2024

International audience

GDF5 as a rejuvenating treatment for age-related neuromuscular failure Open

Massiré Traoré, Chiara Noviello, Amélie Vergnol, Christel Gentil, Marius Halliez , et al. · 2024

Sarcopenia involves a progressive loss of skeletal muscle force, quality and mass during ageing, which results in increased inability and death; however, no cure has been established thus far. Growth differentiation factor 5 (GDF5) has bee…

RhoA Is a Crucial Regulator of Myoblast Fusion Open

Chiara Noviello, Kassandra Kobon, Voahangy Randrianarison-Huetz, Pascal Maire, France Piétri‐Rouxel , et al. · 2023

Satellite cells (SCs) are adult muscle stem cells that are mobilized when muscle homeostasis is perturbed. Here we show that RhoA in SCs is indispensable to have correct muscle regeneration and hypertrophy. In particular, the absence of Rh…

Exploring the protective role of GDF5 against skeletal muscle disuse atrophy Open

Chiara Noviello, Sestina Falcone, Bruno Cadot, Lucile Saillard, Béatrice Matot , et al. · 2022

International audience

Antibacterial and Antibiofilm Properties of Three Resin-Based Dental Composites against Streptococcus mutans Open

Simonetta D’Ercole, Francesco De Angelis, Virginia Biferi, Chiara Noviello, Domenico Tripodi , et al. · 2022

Antibacterial and antibiofilm properties of restorative dental materials may improve restorative treatment outcomes. The aim of this in vitro study was to evaluate Streptococcus mutans capability to adhere and form biofilm on the surface o…

RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth Open

Chiara Noviello, Kassandra Kobon, Léa Delivry, Thomas Guilbert, Florian Britto , et al. · 2021

RhoA within myofibers controls satellite cell microenvironment to allow hypertrophic growth Open

Chiara Noviello, Kassandra Kobon, Léa Delivry, Thomas Guilbert, Francis Julienne , et al. · 2021

Summary Adult skeletal muscle is a plastic tissue that can adapt its size to workload. Here, we show that RhoA within myofibers is needed for overload-induced hypertrophy by controlling satellite cell fusion to the growing myofibers withou…

HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors Open

Alessandra Renzini, Nicoletta Marroncelli, Chiara Noviello, Viviana Moresi, Sergio Adamo · 2018

Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells. Satellite cell behavior is tightly regulated by the surrounding microenvironm…

Srf controls satellite cell fusion through the maintenance of actin architecture Open

Voahangy Randrianarison-Huetz, Aikaterini Papaefthymiou, Gaëlle Herledan, Chiara Noviello, Ulduz Faradova , et al. · 2017

Satellite cells (SCs) are adult muscle stem cells that are mobilized when muscle homeostasis is perturbed. Here, we show that serum response factor (Srf) is needed for optimal SC-mediated hypertrophic growth. We identified Srf as a master …

Histone Deacetylase 4 is crucial for proper skeletal muscle development and disease Open

Viviana Moresi, Nicoletta Marroncelli, Eva Pigna, Chiara Noviello, Silvia Di Francescantonio , et al. · 2015

Epigenetics plays a pivotal role in modulating gene response to physiological or pathological stimuli. Histone Deacetylase inhibitors (HDACi) have been used in the treatment of various cancers1, are effective in several animal models of ne…

HDAC4 is necessary for satellite cell differentiation and muscle regeneration Open

Nicoletta Marroncelli, Chiara Noviello, Silvia Consalvi, Valentina Saccone, Prem Puri , et al. · 2015

In response to injury, skeletal muscle exhibits high capacity to regenerate and epigenetics controls multiple steps of this process (Giordani et al., 2013). It has been demonstrated in vitro that completion of muscle differentiation requir…

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