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View article: Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors
Colorectal cancer-infiltrating NK cell landscape analysis unravels tissue-resident PD-1+ NK cells in microsatellite instability tumors Open
Background Natural killer (NK) cells are innate lymphocytes endowed with potent cytotoxic activity. The presence of tumor-associated NK cells has been correlated with better prognosis in several solid tumors including colorectal cancer (CR…
View article: Pancreatic ductal adenocarcinoma microenvironment: Soluble factors and cancer associated fibroblasts as modulators of NK cell functions
Pancreatic ductal adenocarcinoma microenvironment: Soluble factors and cancer associated fibroblasts as modulators of NK cell functions Open
Pancreatic Ductal Adenocarcinoma (PDAC) is the most frequent pancreatic cancer and represents one of the most aggressive human neoplasms. Typically identified at advance stage disease, most PDAC tumors are unresectable and resistant to sta…
View article: Early CAR<sup>−</sup> CD4<sup>+</sup> T‐lymphocytes recovery following CAR‐T cell infusion: A worse outcome in diffuse large B cell lymphoma
Early CAR<sup>−</sup> CD4<sup>+</sup> T‐lymphocytes recovery following CAR‐T cell infusion: A worse outcome in diffuse large B cell lymphoma Open
CAR − CD4 + T cell lymphopenia is an emerging issue following CAR‐T cell therapy. We analyzed the determinants of CD4 + T cell recovery and a possible association with survival in 31 consecutive patients treated with commercial CAR‐T for d…
View article: A Quantitative Re-Assessment of Microencapsulation in (Pre-Treated) Yeast
A Quantitative Re-Assessment of Microencapsulation in (Pre-Treated) Yeast Open
Most hydrophobes easily diffuse into yeast cells, where they experience reduced evaporation and protection from oxidation, thus allowing inherently biocompatible encapsulation processes. Despite a long-standing industrial interest, the eff…
View article: NK Cell-Based Immunotherapy in Colorectal Cancer
NK Cell-Based Immunotherapy in Colorectal Cancer Open
Human Natural Killer (NK) cells are all round players in immunity thanks to their powerful and immediate response against transformed cells and the ability to modulate the subsequent adaptive immune response. The potential of immunotherapi…
View article: CD19-Targeted Immunotherapies for Diffuse Large B-Cell Lymphoma
CD19-Targeted Immunotherapies for Diffuse Large B-Cell Lymphoma Open
Surgical resection, chemotherapy and radiotherapy were, for many years, the only available cancer treatments. Recently, the use of immune checkpoint inhibitors and adoptive cell therapies has emerged as promising alternative. These cancer …
View article: Role of the Main Non HLA-Specific Activating NK Receptors in Pancreatic, Colorectal and Gastric Tumors Surveillance
Role of the Main Non HLA-Specific Activating NK Receptors in Pancreatic, Colorectal and Gastric Tumors Surveillance Open
Human NK cells can control tumor growth and metastatic spread thanks to their powerful cytolytic activity which relies on the expression of an array of activating receptors. Natural cytotoxicity receptors (NCRs) NKG2D and DNAM-1 are those …
View article: Transparent Bioplastic Derived from CO<sub>2</sub>-Based Polymer Functionalized with Oregano Waste Extract toward Active Food Packaging
Transparent Bioplastic Derived from CO<sub>2</sub>-Based Polymer Functionalized with Oregano Waste Extract toward Active Food Packaging Open
Active packaging materials, biodegradable and from renewable resources, are the most promising substitutes of nonbiodegradable, petroleum-based plastics, toward green and sustainable packaging solutions. In this study, an innovative biopla…
View article: Emulsion technology for the development of novel Alginate-based composite materials for controlled drug delivery applications
Emulsion technology for the development of novel Alginate-based composite materials for controlled drug delivery applications Open
Emulsions have been used for centuries in many fields, such as pharmaceutical, cosmetic, food, and agriculture industry. Manufacturers of pharmaceutical products have recently shown great attention for multifunctional products in which dif…