Chiara Silacci-Fregni
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View article: Neutralization, effector function and immune imprinting of Omicron variants
Neutralization, effector function and immune imprinting of Omicron variants Open
Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain 1 (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of v…
View article: Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants
Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants Open
Currently circulating SARS-CoV-2 variants acquired convergent mutations at receptor-binding domain (RBD) hot spots 1 . Their impact on viral infection, transmission, and efficacy of vaccines and therapeutics remains poorly understood. Here…
View article: Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boost…
View article: Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape
Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape Open
SUMMARY Memory B cells (MBCs) generate rapid antibody responses upon secondary encounter with a pathogen. Here, we investigated the kinetics, avidity and cross-reactivity of serum antibodies and MBCs in 155 SARS-CoV-2 infected and vaccinat…
View article: Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages Open
SARS-CoV-2 Omicron sublineages carry distinct spike mutations and represent an antigenic shift resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters result in pot…
View article: Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients
Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients Open
Patients on dialysis are at risk of severe course of SARS-CoV-2 infection. Understanding the neutralizing activity and coverage of SARS-CoV-2 variants of vaccine-elicited antibodies is required to guide prophylactic and therapeutic COVID-1…
View article: Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift
Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift Open
SUMMARY The recently emerged SARS-CoV-2 Omicron variant harbors 37 amino acid substitutions in the spike (S) protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vacci…
View article: Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients
Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients Open
Patients on dialysis are at risk of severe course of SARS-CoV-2 infection. Understanding the neutralizing activity and coverage of SARS-CoV-2 variants of vaccine-elicited antibodies is required to guide prophylactic and therapeutic COVID-1…
View article: Broad betacoronavirus neutralization by a stem helix–specific human antibody
Broad betacoronavirus neutralization by a stem helix–specific human antibody Open
Targeting a range of betacoranaviruses In the past 20 years, three highly pathogenic β-coronaviruses have crossed from animals to humans, including the most recent: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A spike prot…
View article: SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern Open
SARS-CoV-2 from alpha to epsilon As battles to contain the COVID-19 pandemic continue, attention is focused on emerging variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus that have been deemed variants of co…
View article: A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery
A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery Open
The repeated spillovers of β-coronaviruses in humans along with the rapid emergence of SARS-CoV-2 escape variants highlight the need to develop broad coronavirus therapeutics and vaccines. Five monoclonal antibodies (mAbs) were isolated fr…
View article: SARS-CoV-2 immune evasion by variant B.1.427/B.1.429
SARS-CoV-2 immune evasion by variant B.1.427/B.1.429 Open
SARS-CoV-2 entry is mediated by the spike (S) glycoprotein which contains the receptor-binding domain (RBD) and the N-terminal domain (NTD) as the two main targets of neutralizing antibodies (Abs). A novel variant of concern (VOC) named CA…
View article: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies Open
Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the…
View article: SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies
SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies Open
SARS-CoV-2 transmission is uncontrolled in many parts of the world, compounded in some areas by higher transmission potential of the B1.1.7 variant now seen in 50 countries. It is unclear whether responses to SARS-CoV-2 vaccines based on t…
View article: Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation
Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation Open
Multidonor antibodies are of interest for vaccine design because they can in principle be elicited in the general population by a common set of immunogens. For influenza, multidonor antibodies have been observed against the hemagglutinin (…
View article: Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4
Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4 Open
Parainfluenza virus types 1–4 (PIV1–4) are highly infectious human pathogens, of which PIV3 is most commonly responsible for severe respiratory illness in newborns, elderly, and immunocompromised individuals. To obtain a vaccine effective …