Chiara Tirone
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View article: Characterization of N‐Terminal Acetylated α‐Hemoglobin Stabilizing Protein (AHSP) by Top‐Down High‐Resolution Mass Spectrometry From Human Preterm Newborns Oral Fluid
Characterization of N‐Terminal Acetylated α‐Hemoglobin Stabilizing Protein (AHSP) by Top‐Down High‐Resolution Mass Spectrometry From Human Preterm Newborns Oral Fluid Open
Rationale Alpha‐hemoglobin stabilizing protein (AHSP) is an erythroid‐specific protein forming a stable complex with free α‐hemoglobin, but not with β‐hemoglobin or hemoglobin A (α 2 β 2 ), thus preventing harmful aggregation of α‐hemoglob…
View article: The Relationship Between Salivary Oxidized Thymosin β4 and Thymosin β10 and Oxidative Stress-Related Diseases in Preterm Infants
The Relationship Between Salivary Oxidized Thymosin β4 and Thymosin β10 and Oxidative Stress-Related Diseases in Preterm Infants Open
The study investigates the role of oxidative stress in preterm infants (< 30 weeks) and the potential protective function of the oxidized forms of thymosin β4 (Tβ4) and β10 (Tβ10). A total of 149 saliva samples from 18 infants were coll…
View article: Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates
Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates Open
Importance A multicenter randomized clinical trial (RCT) showed a lung recruitment maneuver using high-frequency oscillatory ventilation just before surfactant administration (ie, intubate-recruit-surfactant-extubate [IN-REC-SUR-E]) improv…
View article: Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial)
Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial) Open
View article: Thymosin β4 and β10 Expression in Human Organs during Development: A Review
Thymosin β4 and β10 Expression in Human Organs during Development: A Review Open
This review summarizes the results of a series of studies performed by our group with the aim to define the expression levels of thymosin β4 and thymosin β10 over time, starting from fetal development to different ages after birth, in diff…
View article: Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN- REC-LISA trial)
Comparison of “IN-REC-SUR-E” and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN- REC-LISA trial) Open
Background: Surfactant is a well-established therapy for preterm neonates affected by respiratory distress syndrome (RDS). Goals of different methods of surfactant administration are to reduce duration of mechanical ventilation and the sev…
View article: Endobronchial ultrasound: a pictorial essay.
Endobronchial ultrasound: a pictorial essay. Open
this manuscript aims to describe the operational potential of both convex endobronchial ultrasound probe and radial endobronchial ultrasound probe technology, focusing on lung cancer. This narrative review is complemented with by the descr…
View article: Respiratory Management of the Preterm Infant: Supporting Evidence-Based Practice at the Bedside
Respiratory Management of the Preterm Infant: Supporting Evidence-Based Practice at the Bedside Open
Extremely preterm infants frequently require some form of respiratory assistance to facilitate the cardiopulmonary transition that occurs in the first hours of life. Current resuscitation guidelines identify as a primary determinant of ove…
View article: The future of Neonatal Lung Ultrasound: validation of an Artificial Intelligence model for interpreting lung scans. A multicentre prospective diagnostic study.
The future of Neonatal Lung Ultrasound: validation of an Artificial Intelligence model for interpreting lung scans. A multicentre prospective diagnostic study. Open
Background Artificial intelligence (AI) is a promising field in the neonatal field. We focused on lung ultrasound (LUS), a useful tool for the neonatologist. Our aim was to train a neural network to create a model able to interpret LUS. Me…
View article: Effects of High-Frequency Oscillatory Ventilation With Volume Guarantee During Surfactant Treatment in Extremely Low Gestational Age Newborns With Respiratory Distress Syndrome: An Observational Study
Effects of High-Frequency Oscillatory Ventilation With Volume Guarantee During Surfactant Treatment in Extremely Low Gestational Age Newborns With Respiratory Distress Syndrome: An Observational Study Open
Objective To evaluate the effect of volume guarantee (VG) combined with high-frequency oscillatory ventilation (HFOV) on respiratory and other physiological parameters immediately after lung recruitment and surfactant administration in HFO…
View article: Effects of Late Surfactant Treatment Delivered After a Recruitment Maneuver on Respiratory Outcomes in Extremely Low Gestational Age Newborns: A Randomized Controlled Pilot Trial – LATE-REC-SURF Trial.
Effects of Late Surfactant Treatment Delivered After a Recruitment Maneuver on Respiratory Outcomes in Extremely Low Gestational Age Newborns: A Randomized Controlled Pilot Trial – LATE-REC-SURF Trial. Open
Background Mechanical ventilation is still needed in most preterm newborns, even in the non-invasive ventilation era. Ventilator-induced lung injury is one of the known pathogenetic factors of bronchopulmonary dysplasia (BPD) in preterm ne…
View article: Investigation by top‐down high‐performance liquid chromatography–mass spectrometry of glutathionylation and cysteinylation of salivary S100A9 and cystatin B in preterm newborns
Investigation by top‐down high‐performance liquid chromatography–mass spectrometry of glutathionylation and cysteinylation of salivary S100A9 and cystatin B in preterm newborns Open
Glutathionylation and cysteinylation can be involved in the protection of critical cysteines from irreversible oxidative damages. S100A9 long and cystatin B, proteins highly represented in the saliva of preterm and at‐term newborns, can un…
View article: Effects of Early Respiratory Physiotherapy on Spontaneous Respiratory Activity of Preterm Infants: Study Protocol for a Randomized Controlled Trial
Effects of Early Respiratory Physiotherapy on Spontaneous Respiratory Activity of Preterm Infants: Study Protocol for a Randomized Controlled Trial Open
Background: Tactile maneuvers stimulating spontaneous respiratory activity in preterm infants are recommended since birth, but data on how and how often these maneuvers are applied in clinical practice are unknown. In the last years, most …
View article: Oxidative and Proteolytic Inactivation of Alpha-1 Antitrypsin in Bronchopulmonary Dysplasia Pathogenesis: A Top-Down Proteomic Bronchoalveolar Lavage Fluid Analysis
Oxidative and Proteolytic Inactivation of Alpha-1 Antitrypsin in Bronchopulmonary Dysplasia Pathogenesis: A Top-Down Proteomic Bronchoalveolar Lavage Fluid Analysis Open
The study investigates the role of the oxidative and proteolytic inactivation of alpha-1 antitrypsin (AAT) in the pathogenesis of bronchopulmonary dysplasia (BPD) in premature infants. Bronchoalveolar lavage fluid (BALF) samples were colle…
View article: Effect of Different Milk Diet on the Level of Fecal Calprotectin in Very Preterm Infants
Effect of Different Milk Diet on the Level of Fecal Calprotectin in Very Preterm Infants Open
Objective: To evaluate the course of fecal calprotectin (FC) in very preterm infants over the first 15 days of life in relation to the type of milk diet. Methods: This study was part of a randomized controlled trial comparing…
View article: A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies?
A modified physiologic test for bronchopulmonary dysplasia: a clinical tool for weaning from CPAP and/or oxygen-therapy the premature babies? Open
TcPCO2 monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.
View article: Extubation from high-frequency oscillatory ventilation in extremely low birth weight infants: a prospective observational study
Extubation from high-frequency oscillatory ventilation in extremely low birth weight infants: a prospective observational study Open
Objective To evaluate if weaning from high-frequency oscillatory ventilation (HFOV) directly to a non-invasive mode of respiratory support is feasible and results in successful extubation in extremely low birth weight (ELBW) infants. Desig…
View article: Nasal high‐frequency oscillatory ventilation and CO<sub>2</sub> removal: A randomized controlled crossover trial
Nasal high‐frequency oscillatory ventilation and CO<sub>2</sub> removal: A randomized controlled crossover trial Open
Objective To compare short‐term application of nasal high‐frequency oscillatory ventilation (nHFOV) with nasal continuous positive airway pressure (nCPAP). Working Hypothesis nHFOV improves CO 2 removal with respect to nCPAP in preterm inf…
View article: Management of pneumothorax in hemodynamically stable preterm infants using high frequency oscillatory ventilation: report of five cases
Management of pneumothorax in hemodynamically stable preterm infants using high frequency oscillatory ventilation: report of five cases Open
In our experience high-frequency oscillatory ventilation provided a conservative management of a significant pneumothorax in preterm newborns hemodynamically stable and requiring mechanical ventilation. This approach allowed us to avoid th…
View article: Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: an observational study
Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: an observational study Open
Objective To investigate whether fetal growth restriction (FGR) diagnosis, based on pathological prenatal fetal Doppler velocimetry, is associated with bronchopulmonary dysplasia (BPD) independently of being small for gestational age (SGA)…
View article: Efficacy of a new technique – INtubate-RECruit-SURfactant-Extubate – “IN-REC-SUR-E” – in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial
Efficacy of a new technique – INtubate-RECruit-SURfactant-Extubate – “IN-REC-SUR-E” – in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial Open