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View article: Murine models to study human NK cells in human solid tumors
Murine models to study human NK cells in human solid tumors Open
Since the first studies, the mouse models have provided crucial support for the most important discoveries on NK cells, on their development, function, and circulation within normal and tumor tissues. Murine tumor models were initially set…
View article: Cord Blood-Derived Natural Killer Cell Exploitation in Immunotherapy Protocols: More Than a Promise?
Cord Blood-Derived Natural Killer Cell Exploitation in Immunotherapy Protocols: More Than a Promise? Open
In the last 20 years, Natural Killer (NK) cell-based immunotherapy has become a promising approach to target various types of cancer. Indeed, NK cells play a pivotal role in the first-line defense against tumors through major histocompatib…
View article: EZH1/2 Inhibitors Favor ILC3 Development from Human HSPC-CD34+ Cells
EZH1/2 Inhibitors Favor ILC3 Development from Human HSPC-CD34+ Cells Open
The dysregulation of epigenetic modifications has a well-established role in the development and progression of hematological malignancies and of solid tumors. In this context, EZH1/2 inhibitors have been designed to interfere with EZH1/2 …
View article: Analysis of the specific common competences of the Degree Courses in Speech Therapy and on the ability to apply in the didactic systems
Analysis of the specific common competences of the Degree Courses in Speech Therapy and on the ability to apply in the didactic systems Open
Law 11 January 2018 n. 3 places the attention of the Health Professions on the specific common skills, which must be evident in the didactic systems to protect the Profession. The purpose of this work is to identify which skills are always…
View article: Analysis of the specific common competences of the Degree Courses in Speech Therapy and on the ability to apply in the didactic systems
Analysis of the specific common competences of the Degree Courses in Speech Therapy and on the ability to apply in the didactic systems Open
This article, taken from the ending research thesis of the studies in Business Administration in Pegaso University,derives from the lack of detailed data on colon-rectal cancer in Apulia, in 2019. The clinical, economic and statisticalstud…
View article: Targeted Therapies: Friends or Foes for Patient’s NK Cell-Mediated Tumor Immune-Surveillance?
Targeted Therapies: Friends or Foes for Patient’s NK Cell-Mediated Tumor Immune-Surveillance? Open
In the last 20 years there has been a huge increase in the number of novel drugs for cancer treatment. Most of them exploit their ability to target specific oncogenic mutations in the tumors (targeted therapies–TT), while others target the…
View article: Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation
Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation Open
Natural killer (NK) cells contribute to the first line of defense against viruses and to the control of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory receptors, primarily of killer Ig-like receptors (…
View article: Effect of Tyrosin Kinase Inhibitors on NK Cell and ILC3 Development and Function
Effect of Tyrosin Kinase Inhibitors on NK Cell and ILC3 Development and Function Open
Tyrosin kinase inhibitors (TKI) sharply improved the prognosis of Chronic Myeloid Leukemia (CML) and of Philadelphia+ Acute Lymphoblastic Leukemia (Ph+ALL) patients. However, TKI are not curative because of the development of resistance an…
View article: Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua
Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua Open
Innate lymphoid cells (ILC) are developmentally related cell subsets that play a major role in innate defenses against pathogens, in lymphoid organogenesis and in tissue remodeling. The best characterized ILC are natural killer (NK) cells.…
View article: NK Cells and Other Innate Lymphoid Cells in Hematopoietic Stem Cell Transplantation
NK Cells and Other Innate Lymphoid Cells in Hematopoietic Stem Cell Transplantation Open
Natural killer (NK) cells play a major role in the T-cell depleted haploidentical hematopoietic stem cell transplantation (haplo-HSCT) to cure high-risk leukemias. NK cells belong to the expanding family of innate lymphoid cells (ILCs). At…